Alexander Ghincea
InstructorCards
About
Research
Publications
2024
Role of Noradrenaline and Macrophage Dynamics in Pulmonary Fibrosis
Ishikawa G, Peng X, Mcgovern J, Ghincea A, Saber T, Sun H, Sauler M, Ryu C, Herzog E. Role of Noradrenaline and Macrophage Dynamics in Pulmonary Fibrosis. 2024, a5206-a5206. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5206.Peer-Reviewed Original Research
2023
Targeting the NLRP3 inflammasome and associated cytokines in scleroderma associated interstitial lung disease
Woo S, Gandhi S, Ghincea A, Saber T, Lee C, Ryu C. Targeting the NLRP3 inflammasome and associated cytokines in scleroderma associated interstitial lung disease. Frontiers In Cell And Developmental Biology 2023, 11: 1254904. PMID: 37849737, PMCID: PMC10577231, DOI: 10.3389/fcell.2023.1254904.Peer-Reviewed Original ResearchSSc-ILDNLRP3 inflammasomeScleroderma-Associated Interstitial Lung DiseaseAssociated interstitial lung diseaseInterstitial lung diseaseNormal lung architectureImproved treatment optionsProgressive fibrotic replacementNovel pathophysiologic insightsComplex rheumatic diseasesImmune dysregulationPathophysiologic insightsRheumatic diseasesClinical benefitIL-18IL-1βLung diseaseTreatment optionsFibrotic replacementLung architectureNovel therapiesClinical significanceInnate immunityDiseaseAdditional studiesMitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review
Ghincea A, Woo S, Yu S, Pivarnik T, Fiorini V, Herzog E, Ryu C. Mitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review. Current Treatment Options In Rheumatology 2023, 9: 204-220. PMID: 38230363, PMCID: PMC10791121, DOI: 10.1007/s40674-023-00211-1.Peer-Reviewed Original ResearchToll-like receptor 9Interstitial lung diseaseLung diseaseSystemic Sclerosis-Associated Interstitial Lung DiseaseAberrant innate immune activationRecent FindingsRecent advancesCause of morbidityInnate immune activationNovel treatment approachesPathogen recognition receptorsCyclic guanosine monophosphate-adenosine monophosphate synthaseReviewSystemic sclerosisSSc patientsImmune dysregulationImmune activationReceptor 9Inflammatory fibrosisScar formationTreatment approachesRecognition receptorsDiseaseImportant unanswered questionsMechanism of releaseReviewUnanswered questionsα1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis
Ishikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog E. α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2023, 324: l639-l651. PMID: 36648147, PMCID: PMC10110730, DOI: 10.1152/ajplung.00119.2022.Peer-Reviewed Original ResearchConceptsAdrenergic nerve supplyIdiopathic pulmonary fibrosisΑ1 adrenoreceptorsPulmonary fibrosisNerve supplyCultured normal human lung fibroblastsInnate immune ligandsLung fibrosis modelNormal human lung fibroblastsSmooth muscle actinHuman lung fibroblastsAdrenal resectionAdrenoreceptor antagonismExtracellular mtDNAIPF cohortImproved survivalΑ1-adrenoreceptor antagonistsLung fibrosisAdrenal sourceFibroblast accumulationAdrenoreceptor antagonistBleomycin modelFibrosis modelLung fibrogenesisMouse model
2022
An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination A Case Report
Ghincea A, Ryu C, Herzog EL. An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination A Case Report. CHEST Journal 2022, 161: e71-e73. PMID: 35131075, PMCID: PMC8814523, DOI: 10.1016/j.chest.2021.07.2160.Peer-Reviewed Case Reports and Technical NotesConceptsIdiopathic pulmonary fibrosisAE-IPFAcute exacerbationPulmonary fibrosisLung diseaseCase reportFatal interstitial lung diseaseMRNA COVID-19 vaccinationChronic lung diseaseInterstitial lung diseaseVaccine-preventable diseasesNovel case reportA Case ReportCOVID-19 vaccinationScar tissue formationRespiratory decompensationAdverse eventsPulmonary embolismVulnerable patientsDrug toxicityPotential associationShort courseDiseaseExacerbationFibrosis
2021
Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD
Althoff M, Ghincea A, Wood L, Holguin F, Sharma S. Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD. The Journal Of Allergy And Clinical Immunology In Practice 2021, 9: 3877-3884. PMID: 34506967, PMCID: PMC8578370, DOI: 10.1016/j.jaip.2021.09.003.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseObstructive sleep apneaDevelopment of asthmaAsthma controlReflux diseaseCommon comorbiditiesSleep apneaInflammatory pathwaysRisk factorsAsthmaComorbiditiesDiseaseHeterogeneous phenotypesObesityHigh rateComplex diseasesManagement recommendationsEndotypesApneaPatientsPathophysiologyGERDEpidemiologyOSA
2019
Predictors of Asthma Exacerbations in Th2 High vs. Th2 Low Patients
Shah A, Chhabra D, Ghincea A, Chung F, Bleecker E, Fitzpatrick A, Castro M, Wenzel S, Gaston B, Israel E, Teague W, Moore W, Peters S, Jarjour N, Erzurum S, Sharma S. Predictors of Asthma Exacerbations in Th2 High vs. Th2 Low Patients. 2019, a1336-a1336. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1336.Peer-Reviewed Original ResearchGastroesophageal Reflux Predicts Asthma Exacerbations in Obese Asthmatics
Ghincea A, Chhabra D, Shah A, Chung F, Bleecker E, Fitzpatrick A, Castro M, Wenzel S, Gaston B, Israel E, Teague W, Moore W, Peters S, Jarjour N, Erzurum S, Holguin F, Sharma S. Gastroesophageal Reflux Predicts Asthma Exacerbations in Obese Asthmatics. 2019, a1282-a1282. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1282.Peer-Reviewed Original Research
2017
Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner
Bruns D, Ghincea A, Ghincea C, Azuma Y, Watson P, Autieri M, Walker L. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World Journal Of Cardiology 2017, 9: 673-684. PMID: 28932356, PMCID: PMC5583540, DOI: 10.4330/wjc.v9.i8.673.Peer-Reviewed Original ResearchHeart failureIL-19DTG miceCardiac morbidityFemale miceInterleukin-19Double transgenic miceAdenosine monophosphate response element-binding proteinCyclic adenosine monophosphate response element-binding proteinMonophosphate response element-binding proteinResponse element-binding proteinSex-specific mannerCardiac functionCardiac remodelingMale miceMurine modelAccelerated morbidityImportant cytokineTransgenic miceMorbidityMiceMurine heartAdditional detrimentRelative expressionMortality