Alaz Ozcan
she/her/hers
Postdoctoral AssociateAbout
Research
Publications
2025
Matrix-producing neutrophils populate and shield the skin
Vicanolo T, Özcan A, Li J, Huerta-López C, Ballesteros I, Rubio-Ponce A, Dumitru A, Nicolás-Ávila J, Molina-Moreno M, Reyes-Gutierrez P, Johnston A, Martone C, Greto E, Quílez-Alvarez A, Calvo E, Bonzon-Kulichenko E, Álvarez-Velez R, Chooi M, Kwok I, González-Bermúdez B, Malleret B, Espinosa F, Zhang M, Wang Y, Sun D, Zhen Chong S, El-Armouche A, Kim K, Udalova I, Greco V, Garcia R, Vázquez J, Dopazo A, Plaza G, Alegre-Cebollada J, Uderhardt S, Ng L, Hidalgo A. Matrix-producing neutrophils populate and shield the skin. Nature 2025, 1-9. PMID: 40108463, DOI: 10.1038/s41586-025-08741-5.Peer-Reviewed Original ResearchRepertoire of proteinsExtracellular matrixInnate immune systemPopulation of neutrophilsImmune diversityPromote barrier functionBacterial invasionInnate immune cellsTGFB signalingForeign moleculesPhysical barrierRing formationBarrier functionImmune systemEnvironmental threatsDefenceDiverse strategiesToxic chemicalsNaive skinTGFBImmune cellsBacteriaNeutrophilsEnzymeProtein
2023
The circadian neutrophil, inside-out
Ovadia S, Özcan A, Hidalgo A. The circadian neutrophil, inside-out. Journal Of Leukocyte Biology 2023, 113: 555-566. PMID: 36999376, PMCID: PMC10583762, DOI: 10.1093/jleuko/qiad038.Peer-Reviewed Original Research
2022
Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity
Özcan A, Boyman O. Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity. Allergy 2022, 77: 3567-3583. PMID: 36067034, PMCID: PMC10087481, DOI: 10.1111/all.15505.Peer-Reviewed Original ResearchConceptsAntimicrobial immunityDefects of neutrophilsHigh-throughput techniquesNeutrophil responsesEffector functionsInvading pathogensCytokine signalingShort life spanAbundant circulating leukocytesAllergic asthma bronchialeBiological clockLymph nodesAutoimmune diseasesTherapeutic avenuesAtopic dermatitisAcquired defectsMouse modelImmune responseAllergic diseasesEffectorImmune systemNeutrophilsNeutrophil granulocytesAsthma bronchialeBiological agentsType 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection
Egholm C, Özcan A, Breu D, Boyman O. Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection. Science Immunology 2022, 7: eabi9733. PMID: 35594340, DOI: 10.1126/sciimmunol.abi9733.Peer-Reviewed Original ResearchConceptsType 2 immunityInterleukin-4Susceptibility to infectionBacterial infectionsImmunity to bacterial infectionPhagocytosis of bacterial particlesInterleukin-4 signalingElimination of neutrophilsLy6G<sup>+</sup> neutrophilsRecurrent bacterial infectionsType 2 inflammationSusceptibility to bacterial infectionsNeutrophil agingMaturation of neutrophilsPredisposed miceAntibacterial defenseDendritic cellsDysregulation of neutrophilsBone marrowEffector functionsAtopic individualsCirculating neutrophilsDecreased phagocytosisAllergic diseasesNeutrophilsCCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection
Özcan A, Collado-Diaz V, Egholm C, Tomura M, Gunzer M, Halin C, Kolios A, Boyman O. CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection. Science Immunology 2022, 7: eabi9126. PMID: 35119939, DOI: 10.1126/sciimmunol.abi9126.Peer-Reviewed Original ResearchConceptsDraining lymph nodesLymph nodesSkin inflammationSkin-draining lymph nodesNeutrophil responsesAggravate skin inflammationEffector immune cellsCCR7 up-regulationCutaneous immune responsesCCR7-dependent migrationRegulate cutaneous inflammationSite of infectionPhagocytosis of neutrophilsSkin-dLNsCCR7 deficiencyDendritic cellsCutaneous immunityCutaneous inflammationImmune cellsMicrobial stimuliNeutrophil homingMouse modelImmune responseInfected skinLymphatic vessels
2021
Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment
Kuett L, Catena R, Özcan A, Plüss A, Schraml P, Moch H, de Souza N, Bodenmiller B. Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment. Nature Cancer 2021, 3: 122-133. PMID: 35121992, PMCID: PMC7613779, DOI: 10.1038/s43018-021-00301-w.Peer-Reviewed Original Research016 Molecular analysis of treatment-refractory pityriasis rubra pilaris uncovers an IL-1 signature with therapeutic proof-of-concept of the anti-IL-1 biological anakinra
Kolios A, Künding T, French L, Mellet M, Johannsen P, Satyam A, Tsokos G, Nobbe S, Özcan A, Contassot E. 016 Molecular analysis of treatment-refractory pityriasis rubra pilaris uncovers an IL-1 signature with therapeutic proof-of-concept of the anti-IL-1 biological anakinra. Journal Of Investigative Dermatology 2021, 141: s151. DOI: 10.1016/j.jid.2021.08.017.Peer-Reviewed Original ResearchClearance of skin-homing CCR7+ neutrophils by conventional type1 dendritic cells regulates cutaneous local autoimmunity and infection
Kolios A, Diaz V, Egholm C, Halin C, Boyman O, Özcan A. Clearance of skin-homing CCR7+ neutrophils by conventional type1 dendritic cells regulates cutaneous local autoimmunity and infection. The Journal Of Immunology 2021, 206: 111.08-111.08. DOI: 10.4049/jimmunol.206.supp.111.08.Peer-Reviewed Original ResearchLymph nodesSkin-draining lymph nodesBone marrow chimerasSecondary lymphoid tissuesPsoriasis-like modelImpaired neutrophil migrationTransgenic mouse modelCutaneous autoimmunityMarrow chimerasDendritic cellsCutaneous inflammationImpaired eliminationLocal inflammationSkin infectionsExacerbated inflammationLymphoid tissueExacerbator phenotypeNeutrophil accumulationMouse modelLocal autoimmunityNeutrophil clearanceInfected skinLymphatic vesselsNeutrophil responsesStaphylococcus aureus
2019
Nanoparticle-coupled topical methotrexate can normalize immune responses and induce tissue remodeling in psoriasis
Özcan A, Sahin D, Impellizzieri D, Nguyen T, Hafner J, Yawalkar N, Kurzbach D, Tan G, Akdis C, Nilsson J, Boyman O, Kolios A. Nanoparticle-coupled topical methotrexate can normalize immune responses and induce tissue remodeling in psoriasis. Journal Of Investigative Dermatology 2019, 140: 1003-1014.e8. PMID: 31678057, DOI: 10.1016/j.jid.2019.09.018.Peer-Reviewed Original ResearchConceptsT cellsMouse modelInduce apoptosis of T cellsCD4<sup>+</sup> T cellsApoptosis of T cellsResident T cellsHuman xenograft mouse modelInterleukin-17 productionTissue remodelingSuppression of cytokine productionNormal immune responseXenograft mouse modelStandard of careImiquimod-induced mouse modelCalcipotriol-betamethasoneTopical methotrexateLocal therapyInduce tissue remodelingConventional methotrexateStromal componentsTreat inflammatory diseasesSkin hyperplasiaTopical alternativesInterleukin-17Topical administration
2016
AirLab: a cloud-based platform to manage and share antibody-based single-cell research
Catena R, Özcan A, Jacobs A, Chevrier S, Bodenmiller B. AirLab: a cloud-based platform to manage and share antibody-based single-cell research. Genome Biology 2016, 17: 142. PMID: 27356760, PMCID: PMC4928244, DOI: 10.1186/s13059-016-1006-0.Peer-Reviewed Original Research
News
Get In Touch
Contacts
Email