Pathophysiology of Nonalcoholic Fatty Liver Disease (NAFLD) in Youth with Obesity

Our research team is studying the causes of fatty liver disease and the role of sugars in liver fat content among children and adolescents with obesity. Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in pediatrics, affecting approximately 7 million children and teens in the U.S. Early onset fatty liver increases the risk of complications later in life. Hispanic youth are affected by NAFLD, with prevalence rates around 45%, compared to 13% in Black/African American youth.

By studying these groups, we aim to understand why certain ethnicities are more susceptible to liver fat accumulation. We would like to understand why some children and young adults develop fatty liver and some do not. We are looking for adolescents aged 12-22 who are considered overweight/obese (BMI >30), identify as Hispanic or Black/African American, and are not on any weight loss medication.

Participants will complete 3 research visits and follow-up visits every 6 months for 2 years. As part of the study, participants will gain valuable health insights, including whether they have fatty liver, prediabetes, or diabetes, with results shared with to their provider as well as guidance on dietary health.

Participants may be compensated up to $690. To learn more or to see if you or your child are eligible, please contact Ermena Refugjati at Ermena.Refugjati@yale.edu or call/text at (203) 684-2546.