Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function
Hall C, Lee J, Murphy E, Gerich M, Dran R, Glover L, Abdulla Z, Skelton M, Colgan S. Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function. Gastroenterology 2020, 159: 984-998.e1. PMID: 32433978, PMCID: PMC7891846, DOI: 10.1053/j.gastro.2020.05.033.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBiopsyCase-Control StudiesCell LineColitis, UlcerativeColonCrohn DiseaseEnergy MetabolismEpithelial CellsFemaleGene Knockdown TechniquesHumansIntestinal MucosaMaleMembrane Transport ProteinsMiceMice, KnockoutMiddle AgedMitochondriaNerve Tissue ProteinsPlasma Membrane Neurotransmitter Transport ProteinsTight JunctionsConceptsInflammatory bowel diseaseIntestinal epithelial cellsColon tissuesTransepithelial electrical resistanceBarrier functionBowel diseaseTight junctionsSeverity of colitisEpithelial cellsInactive Crohn's diseaseIntestinal barrier dysfunctionMucosal biopsy specimensQRT-PCREpithelial integrityQuantitative reverse transcription polymerase chain reactionReverse transcription-polymerase chain reactionIEC cell linesMucosal biopsiesUlcerative colitisCrohn's diseaseControl miceBarrier dysfunctionPolymerase chain reactionBiopsy specimensPatients