Postnatal manganese exposure does not alter dopamine autoreceptor sensitivity in adult and adolescent male rats
McDougall SA, Mohd-Yusof A, Kaplan GJ, Abdulla ZI, Lee RJ, Crawford CA. Postnatal manganese exposure does not alter dopamine autoreceptor sensitivity in adult and adolescent male rats. European Journal Of Pharmacology 2013, 706: 4-10. PMID: 23458069, PMCID: PMC3633626, DOI: 10.1016/j.ejphar.2013.02.030.Peer-Reviewed Original ResearchConceptsDopamine autoreceptor sensitivityEarly Mn exposureAutoreceptor sensitivityDopamine autoreceptorsMale ratsDopamine synthesisMn exposureDorsal striatumD2 receptor concentrationsPostnatal manganese exposureStriatal DOPA accumulationDopamine transporter levelsAdolescent male ratsPostnatal day 1Autoreceptor effectsApomorphine treatmentDOPA accumulationPD-1Haloperidol treatmentPresynaptic mechanismsControl ratsDOPA levelsD2 receptorsLong-term reductionAdult rats