Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits
Udobi KC, Delcimmuto N, Kokenge AN, Abdulla ZI, Perna MK, Skelton MR. Deletion of the creatine transporter gene in neonatal, but not adult, mice leads to cognitive deficits. Journal Of Inherited Metabolic Disease 2019, 42: 966-974. PMID: 31209903, PMCID: PMC6739135, DOI: 10.1002/jimd.12137.Peer-Reviewed Original ResearchConceptsMorris water mazeKnockout miceSLC6A8 geneWater mazeBrain developmentCrT deficiencyTamoxifen-inducible Cre recombinaseAdministration of tamoxifenNovel object recognitionCreatine transporter geneProper control groupSevere intellectual disabilityBrain CrControl miceAdenosine triphosphateHuman ubiquitin C promoterAdult miceBehavioral testingControl groupPrevalent causeLocomotor activityUbiquitin C promoterCognitive deficitsMiceCre recombinase