2000
Midazolam: Effects on Amnesia and Anxiety in Children
Kain Z, Hofstadter M, Mayes L, Krivutza D, Alexander G, Wang S, Reznick J. Midazolam: Effects on Amnesia and Anxiety in Children. Anesthesiology 2000, 93: 676. PMID: 10969300, DOI: 10.1097/00000542-200009000-00016.Peer-Reviewed Original ResearchConceptsOral midazolamMidazolam administrationAnterograde amnesiaGood anterograde amnesiaSignificant anterograde amnesiaInduction of anesthesiaSignificant anxiolytic effectMidazolam groupGeneral anesthesiaSignificant group differencesAnxiolytic effectsBusy operating roomSurgical proceduresPostintervention testingDrug AdministrationControl groupMidazolamBaseline testingAnxiety measurement toolAnxiety of childrenOperating roomAdministrationGroup differencesPicture cardsAnesthesiaAttenuation of the Preoperative Stress Response with Midazolam
Kain Z, Sevarino F, Pincus S, Alexander G, Wang S, Ayoub C, Kosarussavadi B. Attenuation of the Preoperative Stress Response with Midazolam. Anesthesiology 2000, 93: 141-147. PMID: 10861157, DOI: 10.1097/00000542-200007000-00024.Peer-Reviewed Original ResearchConceptsPlacebo groupTreatment groupsPostoperative anxietyPreoperative sedativesPreoperative stress responsePlacebo-controlled trialFirst postoperative weekGreater reductionGlobal health indexAnalgesic consumptionIbuprofen usePlacebo injectionsPostoperative painClinical recoveryIntramuscular midazolamSurgery lengthPain recoveryPostoperative weekAnesthetic techniqueGeneral anesthesiaOutpatient surgeryPreoperative outcomesClinical significanceMidazolamSurgeryParental Presence and a Sedative Premedicant for Children Undergoing Surgery
Kain Z, Mayes L, Wang S, Caramico L, Krivutza D, Hofstadter M. Parental Presence and a Sedative Premedicant for Children Undergoing Surgery. Anesthesiology 2000, 92: 939-946. PMID: 10754612, DOI: 10.1097/00000542-200004000-00010.Peer-Reviewed Original ResearchConceptsPPIA groupSedative groupOverall careParental presenceParental satisfactionOperating roomParental anxietyInduction of anesthesiaPrimary endpointSecondary endpointsPerioperative periodOral midazolamOral sedativesPreoperative anxietySedative premedicantsAnesthesia maskChildrenSedativesAnxietyAdditive effectChild anxietyEndpointCareStandardized measuresIntervention
1999
Postoperative Behavioral Outcomes in Children
Kain Z, Mayes L, Wang S, Hofstadter M. Postoperative Behavioral Outcomes in Children. Anesthesiology 1999, 90: 758-765. PMID: 10078677, DOI: 10.1097/00000542-199903000-00018.Peer-Reviewed Original ResearchConceptsPostoperative behavioral outcomesPostoperative day 1Induction of anesthesiaNegative behavioral changesPlacebo groupDay 1Multivariate logistic regression modelRecent stressful life eventsBehavioral changesFirst postoperative weekPostoperative behavioral changesPaucity of dataLogistic regression modelsPost Hospitalization Behavior QuestionnaireBehavioral outcomesMidazolam groupStressful life eventsPostoperative weekBehavioral recoveryIntervention groupPreoperative anxietyWeek 2Lower anxiety levelsSedative premedicationMeasures of anxiety
1998
Parental Presence during Induction of Anesthesia versus Sedative Premedication
Kain Z, Mayes L, Wang S, Caramico L, Hofstadter M. Parental Presence during Induction of Anesthesia versus Sedative Premedication. Anesthesiology 1998, 89: 1147-1156. PMID: 9822003, DOI: 10.1097/00000542-199811000-00015.Peer-Reviewed Original ResearchConceptsInduction of anesthesiaMidazolam groupControl groupParental presenceOral midazolamEnd pointParental presence groupPrimary end pointSecondary end pointsParental anxiety scoresPerioperative periodPreoperative periodPreoperative anxietySedative premedicationAnesthesia maskAnesthesiaMidazolamOperating roomAnxiety scoresParent anxietyChildrenLess anxietyInterventionAnxietyInduction