2000
Attenuation of the Preoperative Stress Response with Midazolam
Kain Z, Sevarino F, Pincus S, Alexander G, Wang S, Ayoub C, Kosarussavadi B. Attenuation of the Preoperative Stress Response with Midazolam. Anesthesiology 2000, 93: 141-147. PMID: 10861157, DOI: 10.1097/00000542-200007000-00024.Peer-Reviewed Original ResearchConceptsPlacebo groupTreatment groupsPostoperative anxietyPreoperative sedativesPreoperative stress responsePlacebo-controlled trialFirst postoperative weekGreater reductionGlobal health indexAnalgesic consumptionIbuprofen usePlacebo injectionsPostoperative painClinical recoveryIntramuscular midazolamSurgery lengthPain recoveryPostoperative weekAnesthetic techniqueGeneral anesthesiaOutpatient surgeryPreoperative outcomesClinical significanceMidazolamSurgery
1999
Postoperative Behavioral Outcomes in Children
Kain Z, Mayes L, Wang S, Hofstadter M. Postoperative Behavioral Outcomes in Children. Anesthesiology 1999, 90: 758-765. PMID: 10078677, DOI: 10.1097/00000542-199903000-00018.Peer-Reviewed Original ResearchConceptsPostoperative behavioral outcomesPostoperative day 1Induction of anesthesiaNegative behavioral changesPlacebo groupDay 1Multivariate logistic regression modelRecent stressful life eventsBehavioral changesFirst postoperative weekPostoperative behavioral changesPaucity of dataLogistic regression modelsPost Hospitalization Behavior QuestionnaireBehavioral outcomesMidazolam groupStressful life eventsPostoperative weekBehavioral recoveryIntervention groupPreoperative anxietyWeek 2Lower anxiety levelsSedative premedicationMeasures of anxiety