2023
Molecular insights into the force-from-lipids gating of mechanosensitive channels
Bavi N, Cox C, Nikolaev Y, Martinac B. Molecular insights into the force-from-lipids gating of mechanosensitive channels. Current Opinion In Physiology 2023, 36: 100706. DOI: 10.1016/j.cophys.2023.100706.Peer-Reviewed Original ResearchMS channel gatingChannel gatingLipid bilayersMechanosensitive ion channelsLipid principleMechanosensitive channelsChannel proteinsPhysiological processesMolecular underpinningsMolecular insightsMembrane tensionIon channelsMolecular interactionsMechanical forcesCurrent understandingBilayer thinningNew insightsGatingBilayersBlood pressure regulationProteinRegulationInsightsCellsPressure regulation
2021
Extracellular cap domain is an essential component of the TRPV1 gating mechanism
Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI. Extracellular cap domain is an essential component of the TRPV1 gating mechanism. Nature Communications 2021, 12: 2154. PMID: 33846324, PMCID: PMC8041747, DOI: 10.1038/s41467-021-22507-3.Peer-Reviewed Original ResearchConceptsCap domainC-terminusIon conductance pathwaysNumerous physiological processesTransient receptor potential channelsTRP channel familyCryo-EMPhysiological processesChannel familyExtracellular entranceHuman diseasesGating mechanismΒ-sheetConductance pathwayCritical determinantMolecular sensorsOpen probabilityPotential channelsIon selectivityEssential componentTRPV1 functionDomainTerminusProteinDeletion
2017
Principles of Mechanosensing at the Membrane Interface
Bavi N, Nikolaev Y, Bavi O, Ridone P, Martinac A, Nakayama Y, Cox C, Martinac B. Principles of Mechanosensing at the Membrane Interface. Springer Series In Biophysics 2017, 19: 85-119. DOI: 10.1007/978-981-10-6244-5_4.Peer-Reviewed Original ResearchChannel mechanosensitivityTransbilayer pressure profileIon channel mechanosensitivitySpecific cellular responsesMechanosensitive ion channelsMolecular mechanosensorsCellular mechanotransductionIntracellular signalsPhysiological processesCellular responsesMechanosensory transducersLiving cellsExtracellular matrixIon channelsChannel conformationLipid bilayersMembrane interfaceMechanotransductionMechanosensitivityMechanical stimuliCellsCytoskeletonMechanosensorsLipidsConformation
2015
Lipid–protein interactions: Lessons learned from stress
Battle A, Ridone P, Bavi N, Nakayama Y, Nikolaev Y, Martinac B. Lipid–protein interactions: Lessons learned from stress. Biochimica Et Biophysica Acta 2015, 1848: 1744-1756. PMID: 25922225, DOI: 10.1016/j.bbamem.2015.04.012.Peer-Reviewed Original ResearchConceptsLipid-protein interactionsMS channelsLipid bilayersRegulation of cellMechanosensitive membrane channelsMechanosensitive proteinsMembrane proteinsCellular compartmentsTransmembrane portionProkaryotic systemIntracellular signalsPhysical barrierPhysiological processesHypoosmotic shockMembrane channelsMS proteinBiological membranesProteinVariety of rolesCell lysisNormal functionIntracellular spaceEukaryotesCardiac hypertrophyMuscular dystrophy