2020
The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans
Zhou H, Lin Y, Zhao W, Teng Y, Cui Y, Wang T, Li C, Jiang YH, Zhang JJ, Wang Y. The role of Hipk2-p53 pathways in arsenic-induced autistic behaviors: A translational study from rats to humans. Environmental Pollution 2020, 267: 115568. PMID: 33254717, DOI: 10.1016/j.envpol.2020.115568.Peer-Reviewed Original ResearchConceptsCase-control studySerum levelsArsenic exposureHealthy controlsNeuronal apoptosisFrontal cortexAge-matched healthy controlsGestational arsenic exposureHuman case-control studiesASD developmentHigher serum levelsAutistic behaviorASD childrenDose-dependent mannerAutism spectrum disorderPotential mediating pathwaysRat modelRat pupsKey molecular changesImmunohistochemistry analysisTranslational studiesWestern blottingMolecular changesTranslational strategiesMediating pathways
2012
Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders
Chung L, Bey AL, Jiang YH. Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders. Korean Journal Of Physiology And Pharmacology 2012, 16: 369-378. PMID: 23269898, PMCID: PMC3526740, DOI: 10.4196/kjpp.2012.16.6.369.Peer-Reviewed Original ResearchSynaptic plasticityAutism spectrum disorderConditional mutant miceSpectrum disorderHuman autism spectrum disorderMouse modelTherapeutic targetBehavioral abnormalitiesSynaptic defectsVisual cortexMutant miceNeuroanatomical basisDisordersAutistic behaviorAbnormalitiesMiceConstruct validitySubject of debateMost studiesMolecular studiesCore featuresCommon regionHippocampusCortexPlasticity