2024
Bayesian pathway analysis over brain network mediators for survival data
Tian X, Li F, Shen L, Esserman D, Zhao Y. Bayesian pathway analysis over brain network mediators for survival data. Biometrics 2024, 80: ujae132. PMID: 39530270, PMCID: PMC11555425, DOI: 10.1093/biomtc/ujae132.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBayes TheoremBrainComputer SimulationHumansModels, StatisticalNerve NetNeuroimagingSurvival AnalysisConceptsAccelerated failure time modelFailure time modelBrain connectivityAlzheimer's Disease Neuroimaging Initiative studyMaximum information extractionResponse regressionBayesian approachInformation extractionTime modelSurvival dataNoisy componentsUnique edgeWhite matter fiber tractsNetwork configurationBrain networksInterconnection networksNetworkNetwork mediatorsBrain
2022
Identifying imaging genetic associations via regional morphometricity estimation.
Bao J, Wen Z, Kim M, Saykin AJ, Thompson PM, Zhao Y, Shen L. Identifying imaging genetic associations via regional morphometricity estimation. Biocomputing 2022, 27: 97-108. PMID: 34890140, PMCID: PMC8730533.Peer-Reviewed Original ResearchIdentifying highly heritable brain amyloid phenotypes through mining Alzheimer's imaging and sequencing biobank data.
Bao J, Wen Z, Kim M, Zhao X, Lee BN, Jung SH, Davatzikos C, Saykin AJ, Thompson PM, Kim D, Zhao Y, Shen L, . Identifying highly heritable brain amyloid phenotypes through mining Alzheimer's imaging and sequencing biobank data. Biocomputing 2022, 27: 109-120. PMID: 34890141, PMCID: PMC8730532.Peer-Reviewed Original Research
2021
Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes.
Yingxuan E, Yao X, Liu K, Risacher SL, Saykin AJ, Long Q, Zhao Y, Shen L. Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes. AMIA Annual Symposium Proceedings 2021, 2020: 422-431. PMID: 33936415, PMCID: PMC8075527.Peer-Reviewed Original Research
2020
Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes
Zhao Y, Li T, Zhu H. Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes. Biostatistics 2020, 23: 467-484. PMID: 32948880, PMCID: PMC9308456, DOI: 10.1093/biostatistics/kxaa035.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseBayes TheoremHumansNeuroimagingPhenotypePolymorphism, Single NucleotideConceptsHeritability analysisHuman complex traitsLarge-scale phenotypeQuantitative geneticsComplex traitsPhenotypic variationTrait selectionGenetic datasetsSingle phenotypeDownstream analysisGenetic contributionHeritability estimationPhenotypeTraitsCentral roleNeuroimaging phenotypesUnited Kingdom BiobankHierarchical selectionPhenotypic methodsGeneticsHeritabilitySelectionVariationBrain variation
2018
Regional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes
Acosta D, Powell F, Zhao Y, Raj A. Regional vulnerability in Alzheimer's disease: The role of cell‐autonomous and transneuronal processes. Alzheimer's & Dementia 2018, 14: 797-810. PMID: 29306583, PMCID: PMC5994366, DOI: 10.1016/j.jalz.2017.11.014.Peer-Reviewed Original Research