2005
Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells*
Grimm DH, Karihaloo A, Cai Y, Somlo S, Cantley LG, Caplan MJ. Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells*. Journal Of Biological Chemistry 2005, 281: 137-144. PMID: 16278216, DOI: 10.1074/jbc.m507845200.Peer-Reviewed Original ResearchConceptsPolycystin-2Kidney epithelial cellsPolycystin-1Cell proliferationRegulation of tubulogenesisWild-type proteinMultiple fluid-filled cystsAutosomal dominant polycystic kidney diseaseTubule formationEpithelial cellsExtracellular-related kinaseRegulatory machineryPolycystin proteinsBranching morphogenesisNegative regulatorRespective proteinsGenes PKD1Regulates ProliferationChannel mutantsMorphogenesisFluid-filled cystsCell growthProper growthChannel activityProtein
1997
PKD1 interacts with PKD2 through a probable coiled-coil domain
Qian F, Germino F, Cai Y, Zhang X, Somlo S, Germino G. PKD1 interacts with PKD2 through a probable coiled-coil domain. Nature Genetics 1997, 16: 179-183. PMID: 9171830, DOI: 10.1038/ng0697-179.Peer-Reviewed Original ResearchConceptsCoiled-coil domainC-terminusPKD1 gene productAutosomal dominant polycystic kidney diseaseSite-specific mutagenesisLarge cystic kidneysGene productsHomotypic interactionsTubular morphogenesisStructural basisHeterotypic interactionsPKD2TerminusRecent discoveryPathogenic mutationsDominant polycystic kidney diseasePKD1Cystic kidneysPolycystic kidney diseaseCommon pathwayAffected individualsMorphogenesisPolycystinsMutagenesisGenes