2023
Pcdh19 mediates olfactory sensory neuron coalescence during postnatal stages and regeneration
Martinez A, Chung A, Huang S, Bisogni A, Lin Y, Cao Y, Williams E, Kim J, Yang J, Lin D. Pcdh19 mediates olfactory sensory neuron coalescence during postnatal stages and regeneration. IScience 2023, 26: 108220. PMID: 37965156, PMCID: PMC10641745, DOI: 10.1016/j.isci.2023.108220.Peer-Reviewed Original ResearchOlfactory sensory neuronsLateral glomeruliProjection of olfactory sensory neuronsMouse olfactory systemComplement of genesCell adhesion moleculesOlfactory bulbSensory neuronsCadherin superfamilySevere phenotypeSingle cell analysisPostnatal stagesAdhesion moleculesOlfactory systemGlomeruliOlfactory mapGenesOdorant receptorsProtocadherinMaleDifferential effectsCell analysisMOR28FemalesSuperfamily
2020
Investigating higher-order interactions in single-cell data with scHOT
Ghazanfar S, Lin Y, Su X, Lin D, Patrick E, Han Z, Marioni J, Yang J. Investigating higher-order interactions in single-cell data with scHOT. Nature Methods 2020, 17: 799-806. PMID: 32661426, PMCID: PMC7610653, DOI: 10.1038/s41592-020-0885-x.Peer-Reviewed Original ResearchConceptsSingle-cell dataCell fate choiceSingle-cell genomicsDifferential expression testingGene-gene correlationsFate choiceHigher-order interactionsKey genesTranscriptomic dataEmbryonic developmentCoordinated changesExpression testingGenesSubtle changesMouse liverMouse olfactory bulbCellsGenomicsSchotPseudotimeInteractionOlfactory bulbHigher-order measurementsCovariationVariability