2020
Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues
Ng R, Sewanan LR, Brill AL, Stankey P, Li X, Qyang Y, Ehrlich BE, Campbell SG. Contractile work directly modulates mitochondrial protein levels in human engineered heart tissues. AJP Heart And Circulatory Physiology 2020, 318: h1516-h1524. PMID: 32383992, PMCID: PMC7311697, DOI: 10.1152/ajpheart.00055.2020.Peer-Reviewed Original ResearchConceptsMitochondrial proteinsMitochondrial massMitochondrial protein levelsMitochondrial protein expressionMyosin ATPase inhibitorMitochondrial biogenesisExtended tissue culturePathological cardiac adaptationATP demandActive length controlFull recapitulationBiogenesisLength controlHeart tissueProtein levelsATPase inhibitorProtein expressionCulture environmentProteinTissue cultureCardiac physiologyNovel bioreactorVivo conditionsContractile workVitro method
2014
Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation
Cagavi E, Bartulos O, Suh CY, Sun B, Yue Z, Jiang Z, Yue L, Qyang Y. Functional Cardiomyocytes Derived from Isl1 Cardiac Progenitors via Bmp4 Stimulation. PLOS ONE 2014, 9: e110752. PMID: 25522363, PMCID: PMC4270687, DOI: 10.1371/journal.pone.0110752.Peer-Reviewed Original ResearchConceptsCardiac progenitor cellsCardiac repairProliferative abilityProgenitor cellsCell-based cardiac regenerative therapySignificant therapeutic valueCardiac regenerative therapyAdult cardiac progenitor cellsStem cellsCPC culturesHigh proliferative abilityHeart failureCardiac originCardiac differentiationMyocardial infarctionAnterior heart fieldInduction of Bmp4Leading causePotential treatmentRole of BMP4Therapeutic valueCardiac progenitorsUntreated cardiomyocytesProtein expressionRegenerative therapy