2024
Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury
Pan H, Song D, Wang Z, Yang X, Luo P, Li W, Li Y, Gong M, Zhang C. Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury. Gut Microbes 2024, 16: 2439534. PMID: 39673542, PMCID: PMC11649229, DOI: 10.1080/19490976.2024.2439534.Peer-Reviewed Original ResearchConceptsGut microbiotaDrug-induced liver injuryIndole-3-lactic acidComposition of human gut microbiotaWestern style dietDietary modulators of gut microbiotaModulation of gut microbiotaHuman gut microbiotaGut microbiota transplantationModulating gut microbiotaSusceptibility to drug-induced liver injuryIncidence of drug-induced liver injuryDietary fiber interventionLiver injuryDiet-induced variationsBile acid metabolismMicrobiotaTranslocation of lipopolysaccharideImprove liver functionSignaling pathwayDietary shiftsMicrobiota transplantationFiber interventionAcid metabolismIntestinal barrier
2022
Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice
Zhang Y, Luo H, Niu Y, Yang X, Li Z, Wang K, Bi H, Pang X. Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice. Sleep Medicine 2022, 91: 84-92. PMID: 35286865, DOI: 10.1016/j.sleep.2022.02.003.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCo-abundance groupsChronic intermittent hypoxiaIntermittent hypoxiaSystemic inflammationGut microbiotaGut microbiomeElevated systemic inflammationAdverse metabolic outcomesGut microbial dysbiosisMale C57BL/6 micePrevalent sleep disorderFatty acid metabolismIH miceIH exposureMetabolic riskSleep apneaC57BL/6 miceMicrobial dysbiosisComposition of microbiotaMetabolic outcomesIntestinal microbial communityMetabolism disordersMetabolic dysfunctionSleep disorders
2021
Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites
Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites. MBio 2021, 12: 10.1128/mbio.03601-20. PMID: 33785628, PMCID: PMC8092315, DOI: 10.1128/mbio.03601-20.Peer-Reviewed Original ResearchConceptsKetogenic dietGut microbiotaProportion of fatLipid metabolismGlucose intoleranceInsulin resistanceFat accumulationMouse trialsNeurodegenerative diseasesLipid accumulationMore fat accumulationInduced glucose intoleranceLipid metabolism disordersAffected lipid metabolismMetabolism disordersMetabolic disordersGlucose homeostasisGlucose metabolismSource of fatHuman studiesHigh fatTreatment of diseasesMiceBeneficial effectsWeight loss