Featured Publications
Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice
Yang X, Xu Y, Li J, Ran X, Gu Z, Song L, Zhang L, Wen L, Ji G, Wang R. Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice. MSystems 2024, 9: e00127-24. PMID: 38934542, PMCID: PMC11265269, DOI: 10.1128/msystems.00127-24.Peer-Reviewed Original ResearchGut microbiotaGut microbiota dysbiosisDysregulated gut microbiotaGut microbiota transplantationGerm-free miceVirulence factorsSmall intestinal bacteriaBile acid homeostasisMicrobiota dysbiosisDecreased diversityMicrobiota imbalanceMicrobiotaMouse model of cholestasisBile acidsMouse modelIntestinal bacteriaAcid homeostasisMicrobiota transplantationClinical management of patientsGutHepatic bile acidsLong-term effectsPre-clinical findingsModel of cholestasisManagement of patients
2024
Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury
Pan H, Song D, Wang Z, Yang X, Luo P, Li W, Li Y, Gong M, Zhang C. Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury. Gut Microbes 2024, 16: 2439534. PMID: 39673542, PMCID: PMC11649229, DOI: 10.1080/19490976.2024.2439534.Peer-Reviewed Original ResearchConceptsGut microbiotaDrug-induced liver injuryIndole-3-lactic acidComposition of human gut microbiotaWestern style dietDietary modulators of gut microbiotaModulation of gut microbiotaHuman gut microbiotaGut microbiota transplantationModulating gut microbiotaSusceptibility to drug-induced liver injuryIncidence of drug-induced liver injuryDietary fiber interventionLiver injuryDiet-induced variationsBile acid metabolismMicrobiotaTranslocation of lipopolysaccharideImprove liver functionSignaling pathwayDietary shiftsMicrobiota transplantationFiber interventionAcid metabolismIntestinal barrier