Xin Yang, PhD
Postdoctoral AssociateAbout
Research
Publications
Featured Publications
Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice
Yang X, Wang Z, Niu J, Zhai R, Xue X, Wu G, Fang Y, Meng G, Yuan H, Zhao L, Zhang C. Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice. Microbiome 2023, 11: 62. PMID: 36978130, PMCID: PMC10052834, DOI: 10.1186/s40168-023-01507-z.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetesBeta-cell destructionGut microbiotaGut microbiomeDextran sulfate sodium treatmentAutoimmune type 1 diabetesCell destructionIDD developmentDysbiotic gut microbiotaGerm-free micePotential human relevanceType 1 diabetesNormal gut microbiomeGut pathobiontPancreatic inflammationC57BL/6 miceLocal inflammationNormal dietWildtype miceAnimal modelsDiabetesSodium treatmentPathobiontsPancreasHuman relevanceTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl miceBile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice
Yang X, Xu Y, Li J, Ran X, Gu Z, Song L, Zhang L, Wen L, Ji G, Wang R. Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice. MSystems 2024, 9: e00127-24. PMID: 38934542, PMCID: PMC11265269, DOI: 10.1128/msystems.00127-24.Peer-Reviewed Original ResearchGut microbiotaGut microbiota dysbiosisDysregulated gut microbiotaGut microbiota transplantationGerm-free miceVirulence factorsSmall intestinal bacteriaBile acid homeostasisMicrobiota dysbiosisDecreased diversityMicrobiota imbalanceMicrobiotaMouse model of cholestasisBile acidsMouse modelIntestinal bacteriaAcid homeostasisMicrobiota transplantationClinical management of patientsGutHepatic bile acidsLong-term effectsPre-clinical findingsModel of cholestasisManagement of patientsGut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D
Yang X, Huang J, Peng J, Wang P, Wong F, Wang R, Wang D, Wen L. Gut microbiota from B-cell-specific TLR9-deficient NOD mice promote IL-10+ Breg cells and protect against T1D. Frontiers In Immunology 2024, 15: 1413177. PMID: 38903498, PMCID: PMC11187306, DOI: 10.3389/fimmu.2024.1413177.Peer-Reviewed Original ResearchGut microbiotaGerm-free miceToll-like receptor 9Increased gut permeabilityIntestinal microbiotaGut permeabilityT1D developmentGut microbiota compositionFecal samplesTransferred to germ-free miceGut barrier integrityBreg cell differentiationMicrobiota influenceMucin degradationMicrobiota compositionBreg cellsAltered microbiotaMicrobiota impactMicrobiotaGene expressionImmune regulationDevelopment of T1DCell differentiationGutNOD mice
2024
Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury
Pan H, Song D, Wang Z, Yang X, Luo P, Li W, Li Y, Gong M, Zhang C. Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury. Gut Microbes 2024, 16: 2439534. PMID: 39673542, PMCID: PMC11649229, DOI: 10.1080/19490976.2024.2439534.Peer-Reviewed Original ResearchConceptsGut microbiotaDrug-induced liver injuryIndole-3-lactic acidComposition of human gut microbiotaWestern style dietDietary modulators of gut microbiotaModulation of gut microbiotaHuman gut microbiotaGut microbiota transplantationModulating gut microbiotaSusceptibility to drug-induced liver injuryIncidence of drug-induced liver injuryDietary fiber interventionLiver injuryDiet-induced variationsBile acid metabolismMicrobiotaTranslocation of lipopolysaccharideImprove liver functionSignaling pathwayDietary shiftsMicrobiota transplantationFiber interventionAcid metabolismIntestinal barrierThe profile of blood microbiome in new-onset type 1 diabetes children
Yuan X, Yang X, Xu Z, Li J, Sun C, Chen R, Wei H, Chen L, Du H, Li G, Yang Y, Chen X, Cui L, Fu J, Wu J, Chen Z, Fang X, Su Z, Zhang M, Wu J, Chen X, Zhou J, Luo Y, Zhang L, Wang R, Luo F. The profile of blood microbiome in new-onset type 1 diabetes children. IScience 2024, 27: 110252. PMID: 39027370, PMCID: PMC11255850, DOI: 10.1016/j.isci.2024.110252.Peer-Reviewed Original ResearchBlood microbiomeRRNA gene sequencesMicrobiome of patientsGene sequencesOral microbiomePICRUSt analysisMicrobial featuresMicrobiome signaturesPathogenic bacteriaMicrobiomeTranslocation of bacteriaPotential translocationBacteriaRandom forest analysisType 1 diabetic childrenGutNew-onset T1DDiscriminatory powerType 1 diabetesForest analysisOral cavityIncreasing diversityInduce inflammationPICRUStGenus
2023
Microbiota-derived acetate enhances host antiviral response via NLRP3
Niu J, Cui M, Yang X, Li J, Yao Y, Guo Q, Lu A, Qi X, Zhou D, Zhang C, Zhao L, Meng G. Microbiota-derived acetate enhances host antiviral response via NLRP3. Nature Communications 2023, 14: 642. PMID: 36746963, PMCID: PMC9901394, DOI: 10.1038/s41467-023-36323-4.Peer-Reviewed Original ResearchConceptsViral infectionGut-lung axisRespiratory viral infectionsNLRP3-deficient miceIFN-I productionHost immune responsePathogenic viral infectionPotential therapeutic targetType I interferonHost antiviral responseRespiratory virusesIAV infectionMAVS aggregationNLRP3 inflammasomeDeficient miceImmune responseProtective effectTherapeutic targetI interferonGut microbiotaAntiviral responseNLRP3Host defenseInfectionEnhanced induction
2022
A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease
Cheng R, Wang L, Le S, Yang Y, Zhao C, Zhang X, Yang X, Xu T, Xu L, Wiklund P, Ge J, Lu D, Zhang C, Chen L, Cheng S. A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications 2022, 13: 2555. PMID: 35538056, PMCID: PMC9091228, DOI: 10.1038/s41467-022-29968-0.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseDiet interventionPrimary outcomeLiver diseaseTreatment of NAFLDThird primary outcomeTRIAL REGISTRATION NUMBERLiver fat contentCombined aerobic exerciseEffects of interventionsLiver fatAerobic exerciseGlucose metabolismGut microbiotaRegistration numberLarger sample sizeMicrobiota compositionExploratory adPatientsAdverse effectsInterventionIntervention strategiesPrediabetesExerciseGut Microbiota and Immune Modulatory Properties of Human Breast Milk Streptococcus salivarius and S. parasanguinis Strains
Li S, Li N, Wang C, Zhao Y, Cao J, Li X, Zhang Z, Li Y, Yang X, Wang X, Che C, Zhao Y, Wang L, Zhao L, Shen J. Gut Microbiota and Immune Modulatory Properties of Human Breast Milk Streptococcus salivarius and S. parasanguinis Strains. Frontiers In Nutrition 2022, 9: 798403. PMID: 35273986, PMCID: PMC8901577, DOI: 10.3389/fnut.2022.798403.Peer-Reviewed Original ResearchImmune-modulatory propertiesHuman breast milkGut microbiotaBreast milkModulatory propertiesAnti-inflammatory Treg cellsHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsIleal mRNA expressionBlood mononuclear cellsT helper cellsAnti-inflammatory potentialPostnatal week 3Postnatal day 1Microbiota α-diversityImmune response genesTreg cellsBreast feedingHelper cellsMononuclear cellsIleal expressionSuckling miceGut immunityWeaning miceInfant gutChronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice
Zhang Y, Luo H, Niu Y, Yang X, Li Z, Wang K, Bi H, Pang X. Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice. Sleep Medicine 2022, 91: 84-92. PMID: 35286865, DOI: 10.1016/j.sleep.2022.02.003.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCo-abundance groupsChronic intermittent hypoxiaIntermittent hypoxiaSystemic inflammationGut microbiotaGut microbiomeElevated systemic inflammationAdverse metabolic outcomesGut microbial dysbiosisMale C57BL/6 micePrevalent sleep disorderFatty acid metabolismIH miceIH exposureMetabolic riskSleep apneaC57BL/6 miceMicrobial dysbiosisComposition of microbiotaMetabolic outcomesIntestinal microbial communityMetabolism disordersMetabolic dysfunctionSleep disorders