2015
Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.
Araldi E, Chamorro-Jorganes A, van Solingen C, Fernandez-Hernando C, Suarez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Current Vascular Pharmacology 2015, 13: 291-304. PMID: 26156264, DOI: 10.2174/15701611113119990012.Peer-Reviewed Original ResearchConceptsPost-transcriptional levelMonocyte-derived phagocytesFoam cell formationGene regulatorsCell adhesion moleculeModulating microRNAsVascular smooth muscle cellsCell differentiationArterial tree resultsVascular diseaseCell formationMicroRNAsSmooth muscle cellsCap formationVascular cellsFibrous cap formationPotential therapeutic applicationsUnstable fibrous capUnstable coronary syndromesAtherosclerotic vascular diseaseTree resultsMuscle cellsChronic inflammatory diseaseProgression of atherosclerosisLesion-prone sites
2010
MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function
Albinsson S, Suarez Y, Skoura A, Offermanns S, Miano JM, Sessa WC. MicroRNAs Are Necessary for Vascular Smooth Muscle Growth, Differentiation, and Function. Arteriosclerosis Thrombosis And Vascular Biology 2010, 30: 1118-1126. PMID: 20378849, PMCID: PMC2880481, DOI: 10.1161/atvbaha.109.200873.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAortaCell DifferentiationCell ProliferationCells, CulturedDEAD-box RNA HelicasesEmbryo LossEndoribonucleasesGene Expression Regulation, DevelopmentalGenotypeGestational AgeHemorrhageIntegrasesLiver DiseasesMaleMiceMice, KnockoutMicrofilament ProteinsMicroRNAsMuscle DevelopmentMuscle ProteinsMuscle, Smooth, VascularNuclear ProteinsPhenotypeRibonuclease IIIStress FibersTrans-ActivatorsTranscriptional ActivationTransfectionUmbilical ArteriesVasoconstrictionVasodilationConceptsLate embryonic lethalityFundamental cellular processesContractile differentiationContractile protein markersDicer-dependent miRNAsActin stress fibersDeletion of DicerRole of miRNAsDicer resultsOverexpression of microRNAEmbryonic lethalityMiRNA synthesisCellular processesRate-limiting enzymeStress fibersVascular developmentMuscle growthCell typesCellular proliferationMiRNAsVascular smooth muscle growthVascular smooth muscle proliferationMicroRNAsProtein markersDicer