2005
Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation
Fernández-Hernando C, Suárez Y, Lasunción MA. Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation. Molecular And Cellular Neuroscience 2005, 29: 591-602. PMID: 15951198, DOI: 10.1016/j.mcn.2005.04.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCholesterolDiterpenesEnzyme ActivationEnzyme InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsIntracellular Signaling Peptides and ProteinsLovastatinNeuritesPC12 CellsPhosphorylationProtein PrenylationProtein Serine-Threonine KinasesRatsRhoA GTP-Binding ProteinRho-Associated KinasesSterolsTerpenesConceptsNeurite outgrowthNon-sterol mevalonate derivativesPC-12 cell differentiationCellular lipid compositionNon-sterol isoprenoidsEffects of geranylgeraniolBiosynthetic pathwayProtein prenylationRole of cholesterolCofilin phosphorylationRhoA signalingMevalonate derivativesA ReductaseRhoA activationCell differentiationCoenzyme A (HMG-CoA) reductaseLovastatin inhibitsPC-12 cellsCholesterol biosynthesisPathway inactivationRhoA kinaseLipid compositionOutgrowthGeranylgeraniolInhibition
2004
Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin
Suárez Y, Fernández C, Gómez-Coronado D, Ferruelo AJ, Dávalos A, Martínez-Botas J, Lasunción MA. Synergistic upregulation of low-density lipoprotein receptor activity by tamoxifen and lovastatin. Cardiovascular Research 2004, 64: 346-355. PMID: 15485695, DOI: 10.1016/j.cardiores.2004.06.024.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorCholesterolCholesterol, LDLDrug SynergismEstrogen Receptor ModulatorsGene ExpressionHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLovastatinLysosomesReceptors, LDLStimulation, ChemicalTamoxifenConceptsLDL receptor activityLow-density lipoproteinReceptor activityLow density lipoprotein receptor activityPlasma LDL cholesterol levelsLDL cholesterol levelsLipoprotein receptor activityEstrogen receptor modulatorsBreast cancer therapyReceptor mRNA levelsLDL receptor mRNA levelsLDL receptor expressionCholesterol-lowering activityDose-dependent mannerHigh LDL concentrationsHypolipidemic effectsMOLT-4 cellsCholesterol levelsReceptor expressionReceptor modulatorsEstrogen receptorTamoxifenLDL concentrationLDL uptakeLDL receptor
2000
Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells
Montero M, Hernández O, Suárez Y, Matilla J, Ferruelo A, Martı́nez-Botas J, Gómez-Coronado D, Lasunción M. Hydroxymethylglutaryl-coenzyme A reductase inhibition stimulates caspase-1 activity and Th1-cytokine release in peripheral blood mononuclear cells. Atherosclerosis 2000, 153: 303-313. PMID: 11164419, DOI: 10.1016/s0021-9150(00)00417-2.Peer-Reviewed Original ResearchMeSH KeywordsCaspase 1CytokinesFatty Acids, MonounsaturatedFluvastatinHumansHydroxymethylglutaryl CoA ReductasesHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesLeukocytes, MononuclearTh1 CellsConceptsPeripheral blood mononuclear cellsMononuclear cellsHuman peripheral blood mononuclear cellsTh1 cytokine releaseTh2 cytokine releaseTh1/Th2Blood mononuclear cellsEffect of fluvastatinCaspase-1 activationCaspase-1 activityLate atherosclerotic lesionsTh1 responseIL-10Fluvastatin treatmentIL-12IL-18Exerts actionsCytokine releaseIL-4Cholesterol levelsT cellsAtherosclerotic lesionsImmune functionStatinsCaspase-1