2016
Akt‐mediated foxo1 inhibition is required for liver regeneration
Pauta M, Rotllan N, Fernández-Hernando A, Langhi C, Ribera J, Lu M, Boix L, Bruix J, Jimenez W, Suárez Y, Ford DA, Baldán A, Birnbaum MJ, Morales-Ruiz M, Fernández-Hernando C. Akt‐mediated foxo1 inhibition is required for liver regeneration. Hepatology 2016, 63: 1660-1674. PMID: 26473496, PMCID: PMC5177729, DOI: 10.1002/hep.28286.Peer-Reviewed Original ResearchConceptsAkt/protein kinase BCellular eventsProtein kinase BAkt2-deficient miceAbsence of Akt1Lipid droplet formationContribution of AktAkt2-null miceLiver regenerationAbnormal cellular eventsTranscription factorsAKT-FOXO1Kinase BLiver-specific deletionSuccessful liver regenerationPartial hepatectomyHepatic regenerative capabilityAKT1Chronic liver diseaseFOXO1 inhibitionCell proliferationEssential roleImpaired liver regenerationIntracellular mediatorsEfficient liver regeneration
2014
Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis
Rodlan N, Chamorro‐Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández‐Hernando C. Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. The FASEB Journal 2014, 29: 597-610. PMID: 25392271, PMCID: PMC4314230, DOI: 10.1096/fj.14-262097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisBlood GlucoseBone Marrow CellsBone Marrow TransplantationCell MovementCholesterolCytokinesDisease ProgressionInflammationInsulinLeukocytesLipidsLipoproteins, LDLMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ConfocalMicroscopy, FluorescencePlaque, AtheroscleroticProto-Oncogene Proteins c-aktReceptors, LDLConceptsProgression of atherosclerosisSerine-threonine protein kinaseBone marrow cellsAkt2-deficient miceInsulin-responsive tissuesWild-type bone marrow cellsProtein kinaseMarrow cellsAkt2 deficiencyAkt2Higher plasma lipidsWild-type miceMice resultsProatherogenic cytokinesObese subjectsPlasma lipidsProinflammatory cytokinesInsulin resistanceInflammatory responseGlucose levelsAtherosclerotic plaquesCholesterol metabolismAtherosclerosisMacrophage migrationMarked reduction