2023
Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Li C, Tan Y. Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study. Psychiatry Research Neuroimaging 2023, 335: 111724. PMID: 37871408, DOI: 10.1016/j.pscychresns.2023.111724.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaInferior semilunar lobuleSchizophrenia patientsCourse of TDRegional homogeneityResting-state functional magnetic resonance imagingResting-state fMRI studySeverity of TDCerebral regional homogeneityUpper limb scoreNegative Syndrome ScaleNon-TD groupMedial frontal gyrusFunctional magnetic resonance imagingMagnetic resonance imagingLower ReHoReHo valuesHigher ReHoLimb scoreNeuronal degenerationHealthy controlsFunctional abnormalitiesMovement ScaleLeft supramarginal gyrusA significant, functional and replicable risk KTN1 variant block for schizophrenia
Mao Q, Lin X, Yin Q, Liu P, Zhang Y, Qu S, Xu J, Cheng W, Luo X, Kang L, Taximaimaiti R, Zheng C, Zhang H, Wang X, Ren H, Cao Y, Lin J, Luo X. A significant, functional and replicable risk KTN1 variant block for schizophrenia. Scientific Reports 2023, 13: 3890. PMID: 36890161, PMCID: PMC9995530, DOI: 10.1038/s41598-023-27448-z.Peer-Reviewed Original ResearchMeSH KeywordsBrainGenome-Wide Association StudyHumansMagnetic Resonance ImagingMembrane ProteinsPolymorphism, Single NucleotideRNA, MessengerSchizophrenia
2020
Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Hong L, Tan Y. Abnormal functional connectivity of motor circuit in the schizophrenic patients with tardive dyskinesia: A resting-state fMRI study. Neuroscience Letters 2020, 742: 135548. PMID: 33279570, DOI: 10.1016/j.neulet.2020.135548.Peer-Reviewed Original ResearchMeSH KeywordsAdultBasal GangliaCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor CortexNerve NetPrefrontal CortexRestSchizophreniaTardive DyskinesiaConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaRight postcentral gyrusInferior frontal gyrusPostcentral gyrusSchizophrenic patientsWhole brain resting-state functional connectivity (rsFC) analysisMotor circuitsLeft primary motor cortexRight supplementary motor areaFunctional connectivityPathogenesis of TDResting-state fMRI studyResting-state functional connectivity analysisFrontal gyrusAIMS total scoreLeft triangular partPrimary motor cortexAbnormal functional connectivityRight superior parietal lobuleSupplementary motor areaNegative Syndrome ScaleNon-TD groupSuperior parietal lobuleBilateral parietal cortexAltered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study
Liang S, Xue K, Wang W, Yu W, Ma X, Luo S, Zhang J, Sun X, Luo X, Liu F, Zhang Y. Altered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study. Psychiatry Research Neuroimaging 2020, 303: 111134. PMID: 32652482, DOI: 10.1016/j.pscychresns.2020.111134.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainDepressive Disorder, MajorFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung AdultConceptsMajor depressive disorderDrug-naïve major depressive disorderAltered brain functionFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMDD patientsDepressive disorderDefault mode networkBrain functionClinical featuresFunctional impairmentHealthy subjectsLow-frequency fluctuation (ALFF) valuesDrug-naïve MDD patientsResting-state fMRI studyAssessment Short TestTotal FAST scoresALFF valuesNeurocognitive impairmentPatientsConsensus Cognitive BatteryLingual gyrusOccupational functioningFAST scoreGlobal functioning
2019
Choroid Plexus Enlargement and Allostatic Load in Schizophrenia
Zhou Y, Huang J, Zhang P, Fan F, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Yuan Y, Yang F, Savransky A, Ryan M, Goldwaser E, Chiappelli J, Rowland L, Kochunov P, Tan Y, Hong L. Choroid Plexus Enlargement and Allostatic Load in Schizophrenia. Schizophrenia Bulletin 2019, 46: 722-731. PMID: 31603232, PMCID: PMC7147577, DOI: 10.1093/schbul/sbz100.Peer-Reviewed Original ResearchMeSH KeywordsAdultAllostasisAmygdalaBiomarkersChoroid PlexusFemaleHumansLateral VentriclesMagnetic Resonance ImagingMaleSchizophreniaStress, PsychologicalThalamusYoung AdultConceptsChoroid plexusHigher allostatic loadAllostatic loadSex-matched healthy controlsCentral nervous system abnormalitiesFirst-episode schizophrenia patientsChoroid plexus enlargementNervous system abnormalitiesTotal intracranial volumeHealthy controlsThalamus volumeLateral ventricleNeuroendocrine biomarkersSystem abnormalitiesAmygdala volumeSchizophrenia patientsBrain disordersInitial stabilizationIntracranial volumeStructural biomarkersPlexusBrain structuresPatientsSchizophreniaGroup differences
2018
Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement
Yu T, Li Y, Fan F, Cao H, Luo X, Tan S, Yang F, Zhang X, Shugart YY, Hong LE, Li CR, Tan Y. Decreased Gray Matter Volume of Cuneus and Lingual Gyrus in Schizophrenia Patients with Tardive Dyskinesia is Associated with Abnormal Involuntary Movement. Scientific Reports 2018, 8: 12884. PMID: 30150749, PMCID: PMC6110787, DOI: 10.1038/s41598-018-31186-y.Peer-Reviewed Original ResearchConceptsGray matter volumeAbnormal Involuntary Movement ScaleTardive dyskinesiaMatter volumeTD severityAntipsychotic medication treatmentCerebral morphological changesAbnormal involuntary movementsBrain structural magnetic resonance imagesPsychopathological symptomsNegative Syndrome ScaleNon-TD groupVoxel-based morphometryMedication treatmentHealthy controlsGMV changesMotor disordersAIMS scoresInvoluntary movementsMovement ScaleStructural magnetic resonance imagesTemporal cortexSchizophrenia patientsLingual gyrusSyndrome ScaleResting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe
Zhang P, Li Y, Fan F, Li CR, Luo X, Yang F, Yao Y, Tan Y. Resting-state Brain Activity Changes Associated with Tardive Dyskinesia in Patients with Schizophrenia: Fractional Amplitude of Low-frequency Fluctuation Decreased in the Occipital Lobe. Neuroscience 2018, 385: 237-245. PMID: 29909076, DOI: 10.1016/j.neuroscience.2018.06.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsOccipital LobeSchizophreniaTardive DyskinesiaConceptsAbnormal Involuntary Movement ScaleMiddle occipital gyrusRight calcarine sulcusTardive dyskinesiaBrain activity changesClinical parametersLeft middle occipital gyrusSchizophrenic patientsCalcarine sulcusOccipital lobeSeverity of TDAIMS total scoreDecreased brain activityFractional amplitudeResting-state functional magnetic resonance imaging (fMRI) dataResting-state brain activityLow-frequency fluctuationsNegative Syndrome ScaleBrain activityActivity changesConstructional scoresTD groupTD patientsHealthy controlsMagnetic resonance imaging data
2017
Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder
Zhu Y, Tang Y, Zhang T, Li H, Tang Y, Li C, Luo X, He Y, Lu Z, Wang J. Reduced functional connectivity between bilateral precuneus and contralateral parahippocampus in schizotypal personality disorder. BMC Psychiatry 2017, 17: 48. PMID: 28152990, PMCID: PMC5288938, DOI: 10.1186/s12888-016-1146-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingParahippocampal GyrusParietal LobeSchizotypal Personality DisorderTemporal LobeConceptsFunctional connectivityBilateral precuneusSubscale scoresRight precuneusSPD groupSeed-based functional connectivity methodPersonality disorderDecreased functional connectivityAltered functional connectivityRight superior temporal gyrusChinese versionSCL-90 scoresResting-state scanSuperior temporal gyrusSchizophrenia spectrum disordersSchizotypal personality disorderFunctional connectivity methodsHealthy controlsRight parahippocampusParahippocampusSymptom ChecklistBiological markersTemporal gyrusConclusionsOur findingsPrecuneus
2013
Amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study
Xu K, Liu H, Li H, Tang Y, Womer F, Jiang X, Chen K, Zhou Y, Jiang W, Luo X, Fan G, Wang F. Amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study. Journal Of Affective Disorders 2013, 152: 237-242. PMID: 24120087, DOI: 10.1016/j.jad.2013.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainCase-Control StudiesFemaleFrontal LobeFunctional NeuroimagingHumansMagnetic Resonance ImagingMalePutamenConceptsHealthy controlsBipolar disorderLow-frequency fluctuationsBD participantsPrefrontal cortexResting-state functional magnetic resonancePathophysiology of BDBaseline spontaneous activityNeural network abnormalitiesSpontaneous low-frequency fluctuationsBlood oxygenation level-dependent (BOLD) signalDorsal lateral prefrontal cortexState functional connectivityState fMRI studyRegional functional changesFrontal eye fieldRegional brain activityLevel-dependent signalTime of scanningVentral prefrontal cortexFunctional magnetic resonanceALFF methodALFF mapsBD groupBD pathophysiologySex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder
Kong L, Chen K, Womer F, Jiang W, Luo X, Driesen N, Liu J, Blumberg H, Tang Y, Xu K, Wang F. Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder. Journal Of Psychiatric Research 2013, 47: 733-739. PMID: 23453566, PMCID: PMC3626116, DOI: 10.1016/j.jpsychires.2013.02.003.Peer-Reviewed Original ResearchConceptsMajor depressive disorderHealthy controlsGray matter morphologyDepressive disorderPrefrontal cortexSex differencesHigh-resolution structural magnetic resonanceSignificant GM reductionsFemale healthy controlsLeft ventral prefrontal cortexStructural magnetic resonanceNeural systemsVentral prefrontal cortexClinical presentationLimbic regionsMedication-naïve participantsClinical aspectsRight hippocampusStriatal regionsBilateral caudateRight amygdalaHC groupGM reductionSex-related patternsMDD females
2009
Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
Wang F, Jiang T, Sun Z, Teng SL, Luo X, Zhu Z, Zang Y, Zhang H, Yue W, Qu M, Lu T, Hong N, Huang H, Blumberg HP, Zhang D. Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls. Journal Of Psychiatry And Neuroscience 2009, 34: 181-6. PMID: 19448847, PMCID: PMC2674970.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnisotropyBrainGenetic VariationGenotypeHumansMagnetic Resonance ImagingMaleMyelin SheathNerve Tissue ProteinsNeuregulin-1SchizophreniaSequence Analysis, DNAYoung AdultConceptsAnterior cingulumFractional anisotropyHealthy controlsBrain regionsDiagnosis of schizophreniaDiffusion tensorWhite matter connectivityHealthy menWhite matter structuresT carriersMyelin integrityTT subgroupPatientsProminent involvementT alleleReciprocal connectionsAnterior componentC alleleCingulum bundleSchizophrenia groupGenetic susceptibilityCingulum fractional anisotropyNeuregulin1SchizophreniaSmall sample size