2024
Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalities
2023
Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study
Yu T, Li Y, Li N, Huang J, Fan F, Luo X, Tan S, Yang F, Tian B, Tian L, Li C, Tan Y. Regional Homogeneity in schizophrenia patients with tardive dyskinesia: a resting-state fMRI study. Psychiatry Research Neuroimaging 2023, 335: 111724. PMID: 37871408, DOI: 10.1016/j.pscychresns.2023.111724.Peer-Reviewed Original ResearchConceptsAbnormal Involuntary Movement ScaleTardive dyskinesiaInferior semilunar lobuleSchizophrenia patientsCourse of TDRegional homogeneityResting-state functional magnetic resonance imagingResting-state fMRI studySeverity of TDCerebral regional homogeneityUpper limb scoreNegative Syndrome ScaleNon-TD groupMedial frontal gyrusFunctional magnetic resonance imagingMagnetic resonance imagingLower ReHoReHo valuesHigher ReHoLimb scoreNeuronal degenerationHealthy controlsFunctional abnormalitiesMovement ScaleLeft supramarginal gyrusImmune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanismA novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study
Guo X, Wang S, Lin X, Wang Z, Dou Y, Cao Y, Zhang Y, Luo X, Kang L, Yu T, Wang Z, Tan Y, Gao S, Zheng H, Zhao F, Wang H, Wang K, Xie F, Chen W, Luo X. A novel risk variant block across introns 36–45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study. Psychiatric Genetics 2023, 33: 182-190. PMID: 37706495, PMCID: PMC10502955, DOI: 10.1097/ypg.0000000000000344.Peer-Reviewed Original ResearchConceptsGray matter volumeBrain regionsMRNA expressionSubcortical structuresPathogenesis of schizophreniaRisk variantsRisk genesMultiple brain regionsCortical surface areaPotential regulatory effectsHealthy subjectsMatter volumeSignificant associationCortical regionsSame effect directionSchizophreniaNovel risk variantsSchizophrenia risk allelesAssociation studiesCACNA1CIndependent samplesRegulatory effectsNumerous genome-wide association studiesTop risk genesValidation studyPleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDiseaseInflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia
Chen W, Gou M, Wang L, Li N, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Inflammatory disequilibrium and lateral ventricular enlargement in treatment-resistant schizophrenia. European Neuropsychopharmacology 2023, 72: 18-29. PMID: 37058967, DOI: 10.1016/j.euroneuro.2023.03.014.Peer-Reviewed Original ResearchConceptsAnti-inflammatory cytokinesInflammatory disequilibriumImmune-inflammatory response systemPlasma cytokine levelsTreatment-resistant schizophreniaLateral ventricular enlargementLarger lateral ventricle volumesPro-inflammatory cytokinesLateral ventricle volumeNegative Syndrome ScalePotential pathophysiological processesEnzyme-linked immunosorbentHigher PANSS scoresImmune imbalanceCytokine levelsT helperInflammatory imbalanceImmune biomarkersVentricular enlargementClinical manifestationsRegulatory cytokinesHealthy controlsPANSS scoresTh-17Subcortical volumesA significant, functional and replicable risk KTN1 variant block for schizophrenia
Mao Q, Lin X, Yin Q, Liu P, Zhang Y, Qu S, Xu J, Cheng W, Luo X, Kang L, Taximaimaiti R, Zheng C, Zhang H, Wang X, Ren H, Cao Y, Lin J, Luo X. A significant, functional and replicable risk KTN1 variant block for schizophrenia. Scientific Reports 2023, 13: 3890. PMID: 36890161, PMCID: PMC9995530, DOI: 10.1038/s41598-023-27448-z.Peer-Reviewed Original ResearchSerum BDNF levels are involved in the diagnosis and treatment response in patients with PD
Li R, Li J, Liu Y, Li D, Chu L, Zhang J, Luo X, Zhang Y. Serum BDNF levels are involved in the diagnosis and treatment response in patients with PD. Journal Of Affective Disorders 2023, 327: 31-37. PMID: 36739005, DOI: 10.1016/j.jad.2023.01.107.Peer-Reviewed Original ResearchConceptsBaseline serum BDNF levelsSerum BDNF levelsBrain-derived neurotrophic factorState-Trait Anxiety InventoryBDNF levelsPanic disorderTrait anxietyHAMA-14PD patientsHealthy controlsBrain-derived neurotrophic factor serum levelsDiagnosis of panic disorderTreatment response to escitalopramHamilton Anxiety Rating ScaleResponse to escitalopramAnxiety Rating ScaleTreatment responseEscitalopram treatmentAnxiety symptomsNeuropsychological testsNinety PD patientsState-TraitAnxiety InventoryRating ScaleWeeks of treatmentAn Update on Nondopaminergic Treatments for Motor and Non-motor Symptoms of Parkinson’s Disease
Jing XZ, Yuan XZ, Luo X, Zhang SY, Wang XP. An Update on Nondopaminergic Treatments for Motor and Non-motor Symptoms of Parkinson’s Disease. Current Neuropharmacology 2023, 21: 1806-1826. PMID: 35193486, PMCID: PMC10514518, DOI: 10.2174/1570159x20666220222150811.Peer-Reviewed Original ResearchConceptsNon-motor symptomsDopamine replacement therapyPD patientsMotor fluctuationsParkinson's diseaseNondopaminergic treatmentsReplacement therapyCertain non-motor symptomsTraditional dopamine replacement therapyLower urinary tract symptomsUrinary tract symptomsOngoing clinical trialsPotential adverse eventsManagement of motorPositive clinical implicationsManagement of hallucinationsDopaminergic strategiesMotor complicationsNondopaminergic drugsPD psychosisOrthostatic hypotensionTract symptomsAdverse eventsClinical benefitClinical efficacy
2022
Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia
Wang L, Zeng W, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Luo X, Tan S, Wang Z, Li C, Tian B, Tian L, Ma C, Li Y, Tan Y. Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia. Asian Journal Of Psychiatry 2022, 80: 103385. PMID: 36542893, DOI: 10.1016/j.ajp.2022.103385.Peer-Reviewed Original ResearchConceptsSensory gating deficitsFirst-episode schizophreniaGating deficitsS1-S2 differenceHealth controlsChildhood Trauma QuestionnaireChildhood trauma experiencesChildhood traumaS2/S1 ratioOnset of schizophreniaTrauma experiencesP50 sensory gatingSevere childhood traumaEmotional neglectSchizophrenia onsetS1 ratioSensory gatingAuditory conditioningEarly interventionCTQ totalSchizophreniaTraumaTrauma QuestionnaireStimulus paradigmPartial correlation analysisAbnormal cortisol profile during psychosocial stress among patients with schizophrenia in a Chinese population
Zhu X, Zhu Y, Huang J, Zhou Y, Tong J, Zhang P, Luo X, Chen S, Tian B, Tan S, Wang Z, Han X, Tian L, Li CR, Hong LE, Tan Y. Abnormal cortisol profile during psychosocial stress among patients with schizophrenia in a Chinese population. Scientific Reports 2022, 12: 18591. PMID: 36329219, PMCID: PMC9633605, DOI: 10.1038/s41598-022-20808-1.Peer-Reviewed Original ResearchConceptsNegative affect scoresAffect scoresPaced Auditory Serial Addition TaskAuditory Serial Addition TaskMirror-Tracing Persistence TaskSerial Addition TaskNegative Affect ScheduleChallenge taskNegative emotionsAddition taskPersistence taskCortisol responseSignificant interactionSalivary cortisol levelsNegative Syndrome ScaleCortisol profilesCortisol levelsSaliva cortisol levelsPsychological stressPsychosocial stressHealthy volunteersEmotionsSyndrome ScaleTaskAdrenal axis dysfunctionLinear Mixed Model Analysis of Polygenic Hazard Score on Verbal Memory Decline in Alzheimer’s Disease
Wang K, Xu C, Theeke LA, Xiao D, Luo X, Xie C, Initiative A. Linear Mixed Model Analysis of Polygenic Hazard Score on Verbal Memory Decline in Alzheimer’s Disease. Nursing Research 2022, 72: 66-73. PMID: 36097266, DOI: 10.1097/nnr.0000000000000623.Peer-Reviewed Original ResearchConceptsRey Auditory Verbal Learning TestAuditory Verbal Learning TestMini-Mental State Examination scoreVerbal Learning TestVerbal memory declineState Examination scoreAPOE ε4 alleleVerbal memory lossDisease Neuroimaging InitiativeVerbal memoryCognitive measuresLearning TestLinear mixed modelsMemory declineMild cognitive impairmentExamination scoresLongitudinal effectsLinear mixed model analysisBaseline Mini-Mental State Examination scorePolygenic hazard scoreCognitive dysfunctionCognitive impairmentMixed model analysisAlzheimer's Disease Neuroimaging InitiativeAlzheimer's diseaseSerum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong L, Tan Y. Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness. Neuroscience Letters 2022, 788: 136826. PMID: 35944595, DOI: 10.1016/j.neulet.2022.136826.Peer-Reviewed Original ResearchConceptsBrain cortical thicknessCognitive impairmentCognitive deficitsGray matter thicknessSchizophrenia (MATRICS) Consensus Cognitive BatteryAttention/vigilanceConsensus Cognitive BatteryCortical thicknessSerum Hcy levelsFirst-episode patientsHealthy controlsHigh homocysteineWorking memoryHcy levelsCognitive batteryNegative Symptom ScaleCognitive functionTreatment researchHigh-resolution magnetic resonance imagingSymptom ScaleSandwich enzyme-linked immunosorbentSchizophreniaHigher cortical thicknessImpairmentEnzyme-linked immunosorbentAssociation between plasma levels of BDNF and GDNF and the diagnosis, treatment response in first-episode MDD
Liu X, Li P, Ma X, Zhang J, Sun X, Luo X, Zhang Y. Association between plasma levels of BDNF and GDNF and the diagnosis, treatment response in first-episode MDD. Journal Of Affective Disorders 2022, 315: 190-197. PMID: 35908604, DOI: 10.1016/j.jad.2022.07.041.Peer-Reviewed Original ResearchConceptsAntidepressant treatmentPlasma levelsGDNF levelsMATRICS Consensus Cognitive BatteryMDD patientsHealthy controlsDepression severityWeeks antidepressant treatmentFirst-episode depressionPeripheral plasma levelsPeripheral venous bloodWeeks of treatmentDiagnosis of MDDDecreased plasma levelsHAMA-14Plasma BDNFAntidepressant medicationClinical symptomsHDRS-17Venous bloodCognitive dysfunctionPlasma concentrationsTreatment responseConsensus Cognitive BatteryPatientsChildhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume
Wang L, Yin Y, Feng W, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Tian B, Tian L, Li CR, Tan Y. Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume. Journal Of Psychiatry And Neuroscience 2022, 47: e209-e217. PMID: 35654451, PMCID: PMC9177195, DOI: 10.1503/jpn.210178.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCTQ total scoresHealthy controlsCognitive functionChildhood Trauma QuestionnaireTotal scoreCognitive deficitsChildhood trauma experiencesMATRICS Consensus Cognitive BatteryChildhood traumaOrbitofrontal cortexWorse cognitive functionTrauma experiencesHigh-resolution MRIRetrospective designPatientsConsensus Cognitive BatterySchizophreniaTraumaSubscoresSmall sample sizeTrauma QuestionnaireComposite scoreLines of evidenceScoresSex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariatesFurther evidence and meta-analysis support association of a single nucleotide polymorphism rs4765905 in CACNA1C with schizophrenia
Wang Z, Fu Y, Jiang F, Chen L, Chen W, Guo X, Luo X. Further evidence and meta-analysis support association of a single nucleotide polymorphism rs4765905 in CACNA1C with schizophrenia. Schizophrenia Research 2022, 243: 454-455. PMID: 35221147, DOI: 10.1016/j.schres.2022.01.052.Peer-Reviewed Original ResearchDeficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice
Bai W, Luo X, Jin B, Zhu K, Guo W, Zhu X, Qin X, Yang Z, Zhao J, Chen S, Wang R, Hao J, Wang F, Shi Y, Kong D, Zhang W. Deficiency of transmembrane AMPA receptor regulatory protein γ-8 leads to attention-deficit hyperactivity disorder-like behavior in mice. 动物学研究 2022, 43: 851-870. PMID: 36031768, PMCID: PMC9486526, DOI: 10.24272/j.issn.2095-8137.2022.122.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderTARP γKO miceAttention deficit hyperactivity disorder-like behaviorsPrefrontal cortexDysregulation of dopaminergicDevelopment of ADHDGlutamate receptor complexAMPA receptor subunitsTransmembrane AMPA receptor regulatory protein (TARP) γADHD-like behaviorsADHD-like phenotypeMajor behavioral deficitsGlutamatergic transmissionHippocampal synaptosomesRisk factorsSchool-aged childrenAlternative animal modelBehavioral deficitsNew therapiesKnockout miceAnimal modelsProtein γMemory deficitsReceptor subunits
2021
Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease
Taximaimaiti R, Luo X, Wang XP. Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease. Current Neuropharmacology 2021, 19: 2233-2249. PMID: 33998990, PMCID: PMC9185775, DOI: 10.2174/1570159x19666210517115706.Peer-Reviewed Original ResearchConceptsNon-pharmacological treatmentExcessive daytime sleepinessRestless legs syndromeRapid eye movementSleep disordersParkinson's diseaseSide effectsCommon non-motor symptomSleep behavior disorderNon-motor symptomsCommon sleep disorderDeep brain stimulationSleep hygiene educationRelative side effectsQuality of lifeCognitive behavior therapyLegs syndromePD patientsPharmacological treatmentComplementary therapiesDaytime sleepinessSleep qualityBrain stimulationBehavior disorderDiseaseThe mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia
Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong L, Tan Y. The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 828-835. PMID: 34263656, DOI: 10.1177/00048674211031478.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor levelsSerum brain-derived neurotrophic factor (BDNF) levelsNeurotrophic factor levelsFirst-episode schizophreniaQuestionnaire total scoreNegative Syndrome Scale total scoreChildhood Trauma Questionnaire total scoreScale total scoreNegative Syndrome ScaleFactor levelsTotal scoreChildhood traumaHealthy controlsLower serum brain-derived neurotrophic factor levelsAbnormal brain-derived neurotrophic factorChildhood traumatic experiencesSyndrome ScaleBrain-derived neurotrophic factorPathogenesis of schizophreniaEmotional neglectEnzyme-linked immunosorbentSevere childhood traumaChildhood Trauma QuestionnaireClinical symptomsNeurotrophic factor