2019
Elevated serum anti-NMDA receptor antibody levels in first-episode patients with schizophrenia
Tong J, Huang J, Luo X, Chen S, Cui Y, An H, Xiu M, Tan S, Wang Z, Yuan Y, Zhang J, Yang F, Li CR, Hong L, Tan Y. Elevated serum anti-NMDA receptor antibody levels in first-episode patients with schizophrenia. Brain Behavior And Immunity 2019, 81: 213-219. PMID: 31201848, PMCID: PMC6754783, DOI: 10.1016/j.bbi.2019.06.017.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) glutamate receptorsFirst-episode patientsNMDAR antibodiesAntibody levelsHealthy controlsSerum anti-NMDAR antibodyTotal scoreAnti-NMDAR antibodiesNMDAR antibody levelsNMDAR-antibody encephalitisElevated levelsReceptor antibody levelsSerum antibody levelsTreatment of schizophreniaPathogenesis of schizophreniaNegative Syndrome ScaleSymptoms of psychosisEnzyme-linked immunosorbentEtiology of schizophreniaMCCB total scoreAntibody encephalitisPatient groupNMDAR dysfunctionSchizophrenia (MATRICS) Consensus Cognitive BatteryGlutamate receptors
2018
Psychometric properties of the Chinese version of the Functioning Assessment Short Test (FAST) in bipolar disorder
Zhang Y, Long X, Ma X, He Q, Luo X, Bian Y, Xi Y, Sun X, Ng CH, Vieta E, Xiang YT. Psychometric properties of the Chinese version of the Functioning Assessment Short Test (FAST) in bipolar disorder. Journal Of Affective Disorders 2018, 238: 156-160. PMID: 29883937, DOI: 10.1016/j.jad.2018.05.019.Peer-Reviewed Original Research
2017
Correlation between cytochrome P450 2C19 genetic polymorphism and treatment response to escitalopram in panic disorder
He Q, Yuan Z, Liu Y, Zhang J, Yan H, Shen L, Luo X, Zhang Y. Correlation between cytochrome P450 2C19 genetic polymorphism and treatment response to escitalopram in panic disorder. Pharmacogenetics And Genomics 2017, 27: 279-284. PMID: 28614176, DOI: 10.1097/fpc.0000000000000290.Peer-Reviewed Original Research
2016
Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
Mao Q, Tan Y, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Zhang X. Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population. Psychiatry Research 2016, 242: 271-276. PMID: 27315458, DOI: 10.1016/j.psychres.2016.04.029.Peer-Reviewed Original ResearchConceptsPCR-restriction fragment length polymorphismSchizophrenic patientsP50 deficitsNegative symptomsChinese populationNegative Syndrome ScaleRisk of schizophreniaSymptoms of schizophreniaP50 sensory gatingVal allele carriersHan Chinese populationRole of COMTCerebral cortexClinical symptomatologyHealthy controlsNegative subscoreAllele carriersMetS individualsMet/Met individualsControl groupSensory gatingSyndrome ScaleGenotype distributionP50 gatingSchizophrenic subjectsCHRNA4 was associated with prepulse inhibition of schizophrenia in Chinese: a pilot study
Shi J, Wang Z, Tan Y, Fan H, An H, Zuo L, Yang F, Tan S, Li J, Zhang X, Zhou D, Luo X. CHRNA4 was associated with prepulse inhibition of schizophrenia in Chinese: a pilot study. Cognitive Neuropsychiatry 2016, 21: 156-167. PMID: 26982087, DOI: 10.1080/13546805.2016.1155437.Peer-Reviewed Original ResearchConceptsMs prepulse intervalsSingle nucleotide polymorphismsAuditory startle reflexCentral nervous systemPotential endophenotypePrepulse intervalsPrepulse inhibitionSensorimotor gatingTT genotypeGG genotypeNervous systemStartle reflexSchizophreniaPilot studyPPI levelsCHRNA4PatientsNucleotide polymorphismsCurrent studyIndependent replicationInhibitionEndophenotypesLow levelsPPIPolymorphism
2015
BDNF polymorphisms are associated with schizophrenia onset and positive symptoms
Zhang XY, Chen DC, Tan YL, Tan SP, Luo X, Zuo L, Soares JC. BDNF polymorphisms are associated with schizophrenia onset and positive symptoms. Schizophrenia Research 2015, 170: 41-47. PMID: 26603468, DOI: 10.1016/j.schres.2015.11.009.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPositive symptomsBDNF gene variantsCase-control studyBDNF gene polymorphismClinical symptom severityPathophysiology of schizophreniaNegative Syndrome ScaleHan Chinese populationBDNF polymorphismNeurotrophic factorBDNF geneSchizophrenia onsetGene polymorphismsSyndrome ScalePotential associationChinese populationSymptom severityHan Chinese individualsSymptomsPatientsSchizophreniaGene variantsPsychopathological symptomsChinese individuals
2013
Association study on tardive dyskinesia and polymorphisms in COMT and MAOA in Chinese population
Li H, Tan Y, Wang Z, Yang F, Zuo L, Luo X. Association study on tardive dyskinesia and polymorphisms in COMT and MAOA in Chinese population. Psychiatric Genetics 2013, 23: 176. PMID: 23344637, DOI: 10.1097/ypg.0b013e32835e8df6.Peer-Reviewed Original ResearchHealth‐related quality of life and symptom severity in Chinese patients with major depressive disorder
Cao Y, Li W, Shen J, Malison RT, Zhang Y, Luo X. Health‐related quality of life and symptom severity in Chinese patients with major depressive disorder. Asia-Pacific Psychiatry 2013, 5: 276-283. PMID: 23857826, DOI: 10.1111/appy.12059.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntidepressive AgentsAnxietyAsian PeopleChinaDepressive Disorder, MajorFemaleFluoxetineHealth StatusHumansMaleMiddle AgedOutcome Assessment, Health CarePsychiatric Status Rating ScalesQuality of LifeSeverity of Illness IndexSomatoform DisordersSurveys and QuestionnairesYoung Adult
2012
BDNF Val66Met Variant and Smoking in a Chinese Population
Zhang XY, Chen DC, Xiu MH, Luo X, Zuo L, Haile CN, Kosten TA, Kosten TR. BDNF Val66Met Variant and Smoking in a Chinese Population. PLOS ONE 2012, 7: e53295. PMID: 23285275, PMCID: PMC3532294, DOI: 10.1371/journal.pone.0053295.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF Val66Met gene polymorphismBDNF Val66Met polymorphismSerum levelsVal66Met polymorphismGene polymorphismsChinese populationBDNF serum levelsSerum BDNF levelsVal/Val genotypeNumber of cigarettesHealthy male volunteersChinese male populationNicotine dependence scoresNeurotrophic factor familyBDNF Val66Met variantBDNF levelsNeurotrophic factorFagerstrom TestBDNF geneMale volunteersLarge cohortNicotine dependenceVal66Met variantNicotine addictionGenome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking
Pei YF, Zhang L, Yang TL, Han Y, Hai R, Ran S, Tian Q, Shen H, Li J, Zhu XZ, Luo X, Deng HW. Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking. PLOS ONE 2012, 7: e30860. PMID: 22295116, PMCID: PMC3266269, DOI: 10.1371/journal.pone.0030860.Peer-Reviewed Original ResearchConceptsCopy number variantsAssociation studiesGenome-wide association studiesWide association studyGenotyping arraysAffymetrix SNP6.0Genetic mechanismsCNV regionsRelevant genesSusceptibility genesNumber variantsLTBP1GenesComplex disorderFGD4Cdc42Alcohol metabolismEnzymeSuggestive evidenceDownstreamMetabolismTGFB1ReceptorsVariantsPhysiological dependence