2020
Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence
Luo X, Guo X, Luo X, Tan Y, Zhang P, Yang K, Xie T, Shi J, Zhang Y, Xu J, Zuo L, Li C. Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. Addiction Biology 2020, 26: e12888. PMID: 32115811, PMCID: PMC7641293, DOI: 10.1111/adb.12888.Peer-Reviewed Original Research
2018
Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults
Wang K, Liu Y, Ouedraogo Y, Wang N, Xie X, Xu C, Luo X. Principal component analysis of early alcohol, drug and tobacco use with major depressive disorder in US adults. Journal Of Psychiatric Research 2018, 100: 113-120. PMID: 29518578, PMCID: PMC6329582, DOI: 10.1016/j.jpsychires.2018.02.022.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDrug useEarly alcoholDepressive disorderOdds ratioAdult major depressive disorderMultiple logistic regression analysisConfidence intervalsMultiple logistic regressionLogistic regression analysisOverall prevalenceTobacco useUS adultsSignificant associationLogistic regressionRegression analysisNational surveyDisordersAdultsPotential factorsScoresAssociationTobaccoYearsPast year
2010
ADH1A variation predisposes to personality traits and substance dependence
Zuo L, Gelernter J, Kranzler HR, Stein MB, Zhang H, Wei F, Sen S, Poling J, Luo X. ADH1A variation predisposes to personality traits and substance dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2010, 153B: 376-386. PMID: 19526455, PMCID: PMC2861415, DOI: 10.1002/ajmg.b.30990.Peer-Reviewed Original Research
2009
Pro-Opiomelanocortin Gene Variation Related to Alcohol or Drug Dependence: Evidence and Replications Across Family- and Population-based Studies
Zhang H, Kranzler HR, Weiss RD, Luo X, Brady KT, Anton RF, Farrer LA, Gelernter J. Pro-Opiomelanocortin Gene Variation Related to Alcohol or Drug Dependence: Evidence and Replications Across Family- and Population-based Studies. Biological Psychiatry 2009, 66: 128-136. PMID: 19217079, PMCID: PMC2896237, DOI: 10.1016/j.biopsych.2008.12.021.Peer-Reviewed Original Research
2008
Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence
Yang B, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence. Alcohol Clinical And Experimental Research 2008, 32: 2117-2127. PMID: 18828801, PMCID: PMC2975565, DOI: 10.1111/j.1530-0277.2008.00800.x.Peer-Reviewed Original ResearchMultiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations
Luo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2008, 147B: 1028-1039. PMID: 18213616, PMCID: PMC3162230, DOI: 10.1002/ajmg.b.30701.Peer-Reviewed Original Research
2007
ADH7 variation modulates extraversion and conscientiousness in substance‐dependent subjects
Luo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. ADH7 variation modulates extraversion and conscientiousness in substance‐dependent subjects. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2007, 147B: 179-186. PMID: 17918242, PMCID: PMC3160628, DOI: 10.1002/ajmg.b.30589.Peer-Reviewed Original ResearchThe OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk
Zhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Molecular Psychiatry 2007, 13: 531-543. PMID: 17622222, PMCID: PMC3163084, DOI: 10.1038/sj.mp.4002035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcoholismCase-Control StudiesCocaine-Related DisordersEuropeExonsFemaleGenetic Predisposition to DiseaseHaplotypesHeroin DependenceHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Opioid, deltaReceptors, Opioid, kappaRiskSubstance-Related DisordersUnited StatesConceptsLogistic regression analysisSingle nucleotide polymorphismsRegression analysisTag single nucleotide polymorphismsOPRD1 variantsG alleleC alleleDrug dependenceSignificant associationRisk effectsEuropean AmericansStratification artifactSignificant differencesPositive associationHaplotypic associationsMultiple testingAssociationOPRK1OPRD1Dependence riskSDCNR1 Variation Modulates Risk for Drug and Alcohol Dependence
Zuo L, Kranzler HR, Luo X, Covault J, Gelernter J. CNR1 Variation Modulates Risk for Drug and Alcohol Dependence. Biological Psychiatry 2007, 62: 616-626. PMID: 17509535, DOI: 10.1016/j.biopsych.2006.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismBlack or African AmericanCase-Control StudiesChromosome MappingComorbidityFemaleGenetic MarkersGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMalePolymorphism, Single NucleotideReceptor, Cannabinoid, CB1Regression AnalysisRisk FactorsSubstance-Related DisordersWhite PeopleConceptsCannabinoid receptor 1Substance dependenceHealthy control subjectsHuman cannabinoid receptor 1Control subjectsSD patientsT genotypeProtective allelesAlcohol dependenceReceptor 1Disease riskModulate riskCNR1 geneCNR1 variationInitial reportCase-control sampleLarge case-control sampleRegression analysisRiskStrong genetic effectsMarkersSignificant interaction effectMultiple markersAncestry informative markersSNP8
2006
Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans
Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. Human Molecular Genetics 2006, 16: 380-390. PMID: 17185388, PMCID: PMC1853246, DOI: 10.1093/hmg/ddl460.Peer-Reviewed Original ResearchPersonality Traits of Agreeableness and Extraversion are Associated with ADH4 Variation
Luo X, Kranzler HR, Zuo L, Wang S, Gelernter J. Personality Traits of Agreeableness and Extraversion are Associated with ADH4 Variation. Biological Psychiatry 2006, 61: 599-608. PMID: 17069770, PMCID: PMC1853245, DOI: 10.1016/j.biopsych.2006.05.017.Peer-Reviewed Original ResearchAssociation between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence
Zhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J. Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Human Molecular Genetics 2006, 15: 807-819. PMID: 16476706, PMCID: PMC3164878, DOI: 10.1093/hmg/ddl024.Peer-Reviewed Original Research
2005
ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
Luo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies. Pharmacogenetics And Genomics 2005, 15: 755-768. PMID: 16220108, DOI: 10.1097/01.fpc.0000180141.77036.dc.Peer-Reviewed Original ResearchConceptsAlcohol dependenceDrug dependenceSingle nucleotide polymorphismsDiagnosis of alcoholLogistic regression analysisUnrelated healthy controlsUnrelated casesRigorous study designsGene variationRelative risk analysisHaplotype-based haplotype relative riskHealthy controlsRelative riskHaplotype relative risk analysisDisequilibrium testCase-control association analysisInitial studyStudy designTransmission disequilibrium testStrong associationHaplotype relative riskRegression analysisMarkersAffected offspringPresent studyADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association Studies
Luo X, Kranzler HR, Zuo L, Lappalainen J, Yang BZ, Gelernter J. ADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association Studies. Neuropsychopharmacology 2005, 31: 1085-1095. PMID: 16237392, DOI: 10.1038/sj.npp.1300925.Peer-Reviewed Original ResearchAdultAlcohol DehydrogenaseAlcohol-Induced Disorders, Nervous SystemAlcoholismAmericasDNA Mutational AnalysisEuropeFemaleGenes, RecessiveGenetic MarkersGenetic Predisposition to DiseaseGenetic TestingGenetic VariationGenotypeHaplotypesHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticSubstance-Related DisordersWhite PeopleCHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case–control structured association study
Luo X, Kranzler HR, Zuo L, Wang S, Blumberg HP, Gelernter J. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case–control structured association study. Human Molecular Genetics 2005, 14: 2421-2434. PMID: 16000316, DOI: 10.1093/hmg/ddi244.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeHaplotypesHumansMaleMood DisordersReceptor, Muscarinic M2Substance-Related DisordersResponse to Dr. Kopke's comments on haplotypes at the OPRM1 locus
Luo X, Gelernter J, Zhao H, Kranzler HR. Response to Dr. Kopke's comments on haplotypes at the OPRM1 locus. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 135B: 102-102. PMID: 15806579, DOI: 10.1002/ajmg.b.30060.Peer-Reviewed Original Research
2003
Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans
Luo X, Kranzler HR, Zhao H, Gelernter J. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 120B: 97-108. PMID: 12815747, DOI: 10.1002/ajmg.b.20034.Peer-Reviewed Original ResearchAlcoholismBlack PeopleCocaine-Related DisordersExonsFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHaplotypesHumansLinkage DisequilibriumMaleOpioid-Related DisordersPolymorphism, Single NucleotideReceptors, Opioid, muSubstance-Related DisordersUnited StatesWhite People