2017
Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol
Chen Y, Xu C, Harirforoosh S, Luo X, Wang KS. Analysis of PTPRK polymorphisms in association with risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. Journal Of Psychiatric Research 2017, 96: 65-72. PMID: 28987514, PMCID: PMC6195678, DOI: 10.1016/j.jpsychires.2017.09.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCerebellumCholesterolComputer SimulationFamilyGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiddle AgedNeoplasmsPolymorphism, Single NucleotideReceptor-Like Protein Tyrosine Phosphatases, Class 2ConceptsRisk of ADRisk of cancerAlzheimer's diseaseAAO of ADSingle nucleotide polymorphismsTotal cholesterol levelsMultiple logistic regressionLDL cholesterolTotal cholesterolCholesterol levelsAD patientsCancer riskMultiple linear regression analysisLinear regression analysisNeuropsychiatric disordersLogistic regressionDiseaseCancerWilcoxon testExpression levelsRiskRegression analysisGene expression levelsHuman brainGenetic variantsFamily-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease
Wang KS, Liu Y, Xu C, Liu X, Luo X. Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. Journal Of Neuroimmunology 2017, 310: 60-65. PMID: 28778446, PMCID: PMC6167010, DOI: 10.1016/j.jneuroim.2017.06.010.Peer-Reviewed Original ResearchConceptsRisk of ADAlzheimer's diseaseSingle nucleotide polymorphismsAAO of ADHuman brain regionsNervous system developmentApoE expressionOnset (AAO) of ADBrain regionsDiseaseSignificant expressionRiskMarker analysisGenetic variantsAssociationFamily-based association analysisHaplotype analysisPresent studyEquation statisticsAgeFirst studyOnsetFamily-based associationFamily-based sampleExpression
2014
Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer’s disease
Wang KS, Tonarelli S, Luo X, Wang L, Su B, Zuo L, Mao C, Rubin L, Briones D, Xu C. Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer’s disease. Journal Of Neural Transmission 2014, 122: 701-708. PMID: 25410587, DOI: 10.1007/s00702-014-1306-z.Peer-Reviewed Original ResearchConceptsAstrotactin 2AAO of ADASTN2 geneGenome-wide association analysisSingle nucleotide polymorphism panelFuture functional studiesGenetic architectureSignificant hitsAssociation analysisGenesFunctional studiesGenetic variantsAlzheimer's diseasePathogenesis of ADGenetic profileSNPsKaplan-Meier survival analysisGenetic factorsGenotypesAD interventionAD patientsNeurological conditionsAG genotypeCognitive disordersAA genotype
2013
NRG3 gene is associated with the risk and age at onset of Alzheimer disease
Wang KS, Xu N, Wang L, Aragon L, Ciubuc R, Arana TB, Mao C, Petty L, Briones D, Su BB, Luo X, Camarillo C, Escamilla MA, Xu C. NRG3 gene is associated with the risk and age at onset of Alzheimer disease. Journal Of Neural Transmission 2013, 121: 183-192. PMID: 24061483, DOI: 10.1007/s00702-013-1091-0.Peer-Reviewed Original Research
2012
BDNF Val66Met Variant and Smoking in a Chinese Population
Zhang XY, Chen DC, Xiu MH, Luo X, Zuo L, Haile CN, Kosten TA, Kosten TR. BDNF Val66Met Variant and Smoking in a Chinese Population. PLOS ONE 2012, 7: e53295. PMID: 23285275, PMCID: PMC3532294, DOI: 10.1371/journal.pone.0053295.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF Val66Met gene polymorphismBDNF Val66Met polymorphismSerum levelsVal66Met polymorphismGene polymorphismsChinese populationBDNF serum levelsSerum BDNF levelsVal/Val genotypeNumber of cigarettesHealthy male volunteersChinese male populationNicotine dependence scoresNeurotrophic factor familyBDNF Val66Met variantBDNF levelsNeurotrophic factorFagerstrom TestBDNF geneMale volunteersLarge cohortNicotine dependenceVal66Met variantNicotine addiction