2023
Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders
Wang Z, Lin X, Luo X, Xiao J, Zhang Y, Xu J, Wang S, Zhao F, Wang H, Zheng H, Zhang W, Lin C, Tan Z, Cao L, Wang Z, Tan Y, Chen W, Cao Y, Guo X, Pittenger C, Luo X. Pleiotropic Association of CACNA1C Variants With Neuropsychiatric Disorders. Schizophrenia Bulletin 2023, 49: 1174-1184. PMID: 37306960, PMCID: PMC10483336, DOI: 10.1093/schbul/sbad073.Peer-Reviewed Original ResearchConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersIntracranial volumeSingle nucleotide polymorphismsParkinson's diseaseCACNA1C variantsCACNA1C mRNARisk allelesAlcohol use disorderAverage cortical thicknessTotal intracranial volumeMultiple psychiatric disordersFalse discovery rate correctionDifferent neuropsychiatric disordersCortical surface areaBrain cohortCortical thicknessIndependent cohortPsychiatric disordersUse disordersMatter volumeSubcortical structuresSubstance dependenceDisease
2021
The functional impairment of different subtypes and occupational states in euthymic patients with bipolar disorder
Liu X, Ma X, Wang W, Zhang J, Sun X, Luo X, Zhang Y. The functional impairment of different subtypes and occupational states in euthymic patients with bipolar disorder. BMC Psychiatry 2021, 21: 240. PMID: 33957876, PMCID: PMC8103625, DOI: 10.1186/s12888-021-03242-x.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderCognitionCognition DisordersCyclothymic DisorderHumansNeuropsychological TestsSocial AdjustmentConceptsSpeed of processingFunctioning Assessment Short TestNeurocognitive functioningSocial functioningEuthymic BD patientsBD II groupEuthymic patientsGreater social functioningBipolar disorderAssessment Short TestNeurocognitive measuresDSM-IV bipolar disorderOccupational functioningRating ScaleBD patientsOccupational statusInterpersonal relationshipsYoung Mania Rating ScaleFunctioningUnemployed groupShort TestDemographic variablesEmployed groupOccupational stateFunctional impairment
2020
Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder
Wang L, Yin Y, Bian Q, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong LE, Tan Y. Immature defense mechanisms mediate the relationship between childhood trauma and onset of bipolar disorder. Journal Of Affective Disorders 2020, 278: 672-677. PMID: 33125910, DOI: 10.1016/j.jad.2020.10.029.Peer-Reviewed Original ResearchConceptsChildhood Trauma QuestionnaireDiagnosis of BDBipolar disorderBD-IIChildhood traumaTotal scoreImmature defense mechanismsImmature defense stylesImportant risk factorDefense Style QuestionnairePhysical neglectPsychosocial intervention strategiesDefense mechanismsEmotional abuseSevere childhood traumaBD patientsDefense stylesRisk factorsHealthy controlsHealthy volunteersChildhood traumatic experiencesPatientsDSM-IVTraumaTrauma Questionnaire
2018
Psychometric properties of the Chinese version of the Functioning Assessment Short Test (FAST) in bipolar disorder
Zhang Y, Long X, Ma X, He Q, Luo X, Bian Y, Xi Y, Sun X, Ng CH, Vieta E, Xiang YT. Psychometric properties of the Chinese version of the Functioning Assessment Short Test (FAST) in bipolar disorder. Journal Of Affective Disorders 2018, 238: 156-160. PMID: 29883937, DOI: 10.1016/j.jad.2018.05.019.Peer-Reviewed Original Research
2013
Amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study
Xu K, Liu H, Li H, Tang Y, Womer F, Jiang X, Chen K, Zhou Y, Jiang W, Luo X, Fan G, Wang F. Amplitude of low-frequency fluctuations in bipolar disorder: A resting state fMRI study. Journal Of Affective Disorders 2013, 152: 237-242. PMID: 24120087, DOI: 10.1016/j.jad.2013.09.017.Peer-Reviewed Original ResearchMeSH KeywordsAdultBipolar DisorderBrainCase-Control StudiesFemaleFrontal LobeFunctional NeuroimagingHumansMagnetic Resonance ImagingMalePutamenConceptsHealthy controlsBipolar disorderLow-frequency fluctuationsBD participantsPrefrontal cortexResting-state functional magnetic resonancePathophysiology of BDBaseline spontaneous activityNeural network abnormalitiesSpontaneous low-frequency fluctuationsBlood oxygenation level-dependent (BOLD) signalDorsal lateral prefrontal cortexState functional connectivityState fMRI studyRegional functional changesFrontal eye fieldRegional brain activityLevel-dependent signalTime of scanningVentral prefrontal cortexFunctional magnetic resonanceALFF methodALFF mapsBD groupBD pathophysiology