2024
N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
Tong J, Yang K, Li W, Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Zhao Y, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Tian B, Li C, Hong L, Tan Y. N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia. Schizophrenia Bulletin 2024, sbae180. PMID: 39406395, DOI: 10.1093/schbul/sbae180.Peer-Reviewed Original ResearchFirst-episode schizophreniaSensory gating deficitsN-methyl-D-aspartate receptorsFirst-episode schizophrenia groupGating deficitsN-methyl-D-aspartateP50 ratioSensory gatingExposure to antipsychotic medicationAb levelsHealthy controlsAntipsychotic medication exposureFirst-episode patientsDiagnosis of schizophreniaImpaired sensory gatingP50 sensory gating deficitN-methyl-D-aspartate receptor antibodiesAntipsychotic medicationFirst-episodeNon-smoking healthy controlsP50 differenceSchizophreniaPartial correlation analysisEnzyme-linked immunosorbent assayDeficits
2022
Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia
Wang L, Zeng W, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Luo X, Tan S, Wang Z, Li C, Tian B, Tian L, Ma C, Li Y, Tan Y. Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia. Asian Journal Of Psychiatry 2022, 80: 103385. PMID: 36542893, DOI: 10.1016/j.ajp.2022.103385.Peer-Reviewed Original ResearchConceptsSensory gating deficitsFirst-episode schizophreniaGating deficitsS1-S2 differenceHealth controlsChildhood Trauma QuestionnaireChildhood trauma experiencesChildhood traumaS2/S1 ratioOnset of schizophreniaTrauma experiencesP50 sensory gatingSevere childhood traumaEmotional neglectSchizophrenia onsetS1 ratioSensory gatingAuditory conditioningEarly interventionCTQ totalSchizophreniaTraumaTrauma QuestionnaireStimulus paradigmPartial correlation analysis
2016
Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population
Mao Q, Tan Y, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Zhang X. Association of catechol-O-methyltransferase Val108/158 Met genetic polymorphism with schizophrenia, P50 sensory gating, and negative symptoms in a Chinese population. Psychiatry Research 2016, 242: 271-276. PMID: 27315458, DOI: 10.1016/j.psychres.2016.04.029.Peer-Reviewed Original ResearchConceptsPCR-restriction fragment length polymorphismSchizophrenic patientsP50 deficitsNegative symptomsChinese populationNegative Syndrome ScaleRisk of schizophreniaSymptoms of schizophreniaP50 sensory gatingVal allele carriersHan Chinese populationRole of COMTCerebral cortexClinical symptomatologyHealthy controlsNegative subscoreAllele carriersMetS individualsMet/Met individualsControl groupSensory gatingSyndrome ScaleGenotype distributionP50 gatingSchizophrenic subjects