2016
Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence
Zuo L, Garcia-Milian R, Guo X, Zhong C, Tan Y, Wang Z, Wang J, Wang X, Kang L, Lu L, Chen X, Li CR, Luo X. Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Genes 2016, 7: 95. PMID: 27827986, PMCID: PMC5126781, DOI: 10.3390/genes7110095.Peer-Reviewed Original ResearchNicotinic cholinergic receptor genesRisk genesRisk variantsCholinergic receptor genesReceptor geneMouse brainGenomic regionsEQTL analysisBioinformatics analysisProtein structureNicotinic acetylcholine receptorsGenesMouse brain samplesGenetic variantsAcetylcholine receptorsIndependent humanExpressionPotential functionVariantsImportant roleSplicingTranscriptionBrain samplesCHRNA5-A3RNA
2014
Genome‐wide association discoveries of alcohol dependence
Zuo L, Lu L, Tan Y, Pan X, Cai Y, Wang X, Hong J, Zhong C, Wang F, Zhang X, Vanderlinden LA, Tabakoff B, Luo X. Genome‐wide association discoveries of alcohol dependence. American Journal On Addictions 2014, 23: 526-539. PMID: 25278008, PMCID: PMC4187224, DOI: 10.1111/j.1521-0391.2014.12147.x.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide levelPotential biological functionsGWAS samplesADH clusterGenome-wide association discoveryRisk variantsBiological functionsAlcohol dehydrogenase clusterWide significant associationsRobust risk locusCis-eQTLsRisk lociNrd1Association studiesKIAA0040PKNOX2RNA expressionImportant roleHTR7Replicable associationsIndividual samplesSERINC2Mouse brainVariants