Xingguang Luo, MD
Associate Research Scientist in PsychiatryCards
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
About
Titles
Associate Research Scientist in Psychiatry
Assistant Professor, Psychiatry
Appointments
Psychiatry
Associate Research ScientistPrimary
Other Departments & Organizations
- Division of Human Genetics
- Psychiatry
- Yale Global Mental Health Program
Education & Training
- Assistant Professor (2006-2012)
- Yale University School of Medicine (2012)
- Post-doc (2000-2003)
- Yale University (2003)
- MD
- Shanghai Medical University (2000)
Research
Overview
NIH R01: Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
NIH R21: Deep sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependence
NIH R21: Post-GWAS transcriptome-wide LncRNA profiling in alcoholism
Medical Research Interests
Behavior and Behavior Mechanisms; Mental Disorders; Psychiatry and Psychology
Public Health Interests
Genetics, Genomics, Epigenetics; Mental Health; Substance Use, Addiction
ORCID
0000-0003-3585-042X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xingguang Luo's published research.
Publications Timeline
A big-picture view of Xingguang Luo's research output by year.
Research Interests
Research topics Xingguang Luo is interested in exploring.
Chiang-Shan Ray Li, MD, PhD
Joel Gelernter, MD
John Krystal, MD
Heping Zhang, PhD
Lingeng Lu, MD, PhD
Bao-Zhu Yang, PhD
179Publications
4,231Citations
Mental Disorders
Publications
2024
N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
Tong J, Yang K, Li W, Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Zhao Y, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Tian B, Li C, Hong L, Tan Y. N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia. Schizophrenia Bulletin 2024, sbae180. PMID: 39406395, DOI: 10.1093/schbul/sbae180.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaSensory gating deficitsN-methyl-D-aspartate receptorsFirst-episode schizophrenia groupGating deficitsN-methyl-D-aspartateP50 ratioSensory gatingExposure to antipsychotic medicationAb levelsHealthy controlsAntipsychotic medication exposureFirst-episode patientsDiagnosis of schizophreniaImpaired sensory gatingP50 sensory gating deficitN-methyl-D-aspartate receptor antibodiesAntipsychotic medicationFirst-episodeNon-smoking healthy controlsP50 differenceSchizophreniaPartial correlation analysisEnzyme-linked immunosorbent assayDeficitsThe Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia
Guo X, Luo X, Huang X, Zhang Y, Ji J, Wang X, Wang K, Wang J, Pan X, Chen B, Tan Y, Luo X. The Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia. Anatolian Journal Of Psychiatry 2024, 25: 413-420. PMID: 39148597, PMCID: PMC11322729, DOI: 10.5152/alphapsychiatry.2024.241616.Peer-Reviewed Original ResearchConceptsGray matter volumeAssociated with volumetric reductionsBasal gangliaSuperior frontal cortexDevelopment of schizophreniaSingle-nucleotide polymorphismsRisk of schizophreniaNucleus accumbensFrontal cortexPosterior cingulateMatter volumeInsular cortexBrain areasSchizophreniaSubcortical nucleiVolumetric reductionCortexPutamenCortical areasIndependent samplesRisk allelesSignificance of variantsRegulatory regionsMRNA expressionGenome-wide association studiesModifications on histone tails in Parkinson's disease.
Mao Q, Luo Z, Wang K, Chen B, Wang Z, Zhang Y, Wang X, Luo X. Modifications on histone tails in Parkinson's disease. SciBase Neurology 2024, 2 PMID: 39145143, PMCID: PMC11323098, DOI: 10.52768/neurology/1017.Peer-Reviewed Original ResearchConceptsHistone modificationsEpigenetic regulation of genesGene regulatory regionsGene expression regulationHistone tail modificationsRegulation of genesHistone marksChromatin structureRepressive marksRegulatory regionsExpression regulationHistone tailsTail modificationsHistone H2AEpigenetic modificationsEpigenetic regulationEpigenetic mechanismsHistoneGene expressionGenesGSK-J4Neural stem cellsA-synucleinEnvironmental factorsParkinson's diseaseRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesPhenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder
Guo X, Luo X, Zhang Y, Yu Z, Tan Z, Cao L, Ji J, Wang X, Wang K, Wang Z, Li C, Tan Y, Luo X. Phenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder. Asian Journal Of Psychiatry 2024, 98: 104145. PMID: 38959548, DOI: 10.1016/j.ajp.2024.104145.Peer-Reviewed Original ResearchMachine Learning-Based Prediction of Binge Drinking among Adults in the United State: Analysis of the 2022 Health Information National Trends Survey
Huang X, Dai Z, Wang K, Luo X. Machine Learning-Based Prediction of Binge Drinking among Adults in the United State: Analysis of the 2022 Health Information National Trends Survey. 2024, 1-10. DOI: 10.1145/3670085.3670090.Peer-Reviewed Original ResearchConceptsHealth Information National Trends SurveyNational Trends SurveySupport vector machineTrends SurveyBinge drinkingMachine learningMultiple health behaviour interventionsRisk factors of binge drinkingHealth behavior interventionsImprove health outcomesPrevalence of binge drinkingK-nearest neighborHealth outcomesSocial mediaTobacco useU.S. adultsRadial basis functionBehavioral interventionsUnited StatesAlcohol useNaive BayesFeature selectionLogistic regressionK-nearestMachine learning-based predictionSerum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders
Li Y, Wang L, Huang J, Zhang P, Zhou Y, Tong J, Chen W, Gou M, Tian B, Li W, Luo X, Tian L, Hong L, Li C, Tan Y. Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders. Frontiers In Psychiatry 2024, 15: 1357293. PMID: 38680780, PMCID: PMC11046465, DOI: 10.3389/fpsyt.2024.1357293.Peer-Reviewed Original ResearchCitationsAltmetricConceptsYoung Mania Rating ScaleBD-DAffective disordersBD-MDepressive symptomsHamilton Depression Scale-17 itemsRemission of depressive symptomsKynurenic acidMania Rating ScaleAcute manic episodeWeeks of antidepressantsRisk of MDDKynurenine pathwayAssociated with remissionAntipsychotic medicationDisrupt tryptophan metabolismManic symptomsDepressive disorderBD-D.Depressive episodeHAMD-17Mood stabilizersManic episodesBipolar disorderTryptophan pathwayCorrelation of allostatic load and perceived stress with clinical features in first-episode schizophrenia
Zhou Y, Wang L, Yang K, Huang J, Li Y, Li W, Zhang P, Fan F, Yin Y, Yu T, Chen S, Luo X, Tan S, Wang Z, Feng W, Tian B, Tian L, Li C, Tan Y. Correlation of allostatic load and perceived stress with clinical features in first-episode schizophrenia. Journal Of Psychiatric Research 2024, 172: 156-163. PMID: 38382239, DOI: 10.1016/j.jpsychires.2024.02.025.Peer-Reviewed Original ResearchCitationsConceptsFirst-episode schizophreniaCalgary Depression Scale for SchizophreniaPositive and Negative Syndrome ScalePerceived stressPositive symptomsAllostatic loadPSS scoresSeverity of positive symptomsClinical features of schizophreniaNegative Syndrome ScaleFeatures of schizophreniaChronic physiological stressAssociated with depressive symptomsEtiology of schizophreniaAssess subjective stressOccurrence of schizophreniaHealthy controlsPerceived Stress Scale-14Clinical featuresCDSS scoresSyndrome ScaleDepressive symptomsSchizophreniaSubjective stressStressor typeDoes Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder?
Jiao Q, Dong Y, Ma X, Ji S, Liu X, Zhang J, Sun X, Li D, Luo X, Zhang Y. Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder? Neuropsychiatric Disease And Treatment 2024, 20: 353-361. PMID: 38415074, PMCID: PMC10898600, DOI: 10.2147/ndt.s453447.Peer-Reviewed Original ResearchConceptsHDRS-17 total scoreFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMajor depressive disorderHDRS-17FED patientsCPT-IPCognitive functionBaseline cognitive functionTotal scoreDepressive disorderFirst-episodeDrug-naivePatients' responses to antidepressant treatmentFunctioning Assessment Short Test total scoreResponse to antidepressant treatmentHamilton Depression Rating ScaleFunctioning Assessment Short Test scoreConsensus Cognitive BatteryDepression Rating ScaleAssociated with worse cognitive functionSpeed of processingHamilton Anxiety ScaleDrug-naive patientsInterpersonal relationship domain
2023
Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence
Yang K, Du R, Yang Q, Zhao R, Fan F, Chen S, Luo X, Tan S, Wang Z, Yu T, Tian B, Le T, Li C, Tan Y. Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence. Brain Imaging And Behavior 2023, 18: 331-342. PMID: 38078981, DOI: 10.1007/s11682-023-00838-7.Peer-Reviewed Original Research
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