2014
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat. Cell 2014, 159: 306-317. PMID: 25303527, PMCID: PMC4509746, DOI: 10.1016/j.cell.2014.09.010.Peer-Reviewed Original ResearchConceptsAgRP neuronsFundamental cellular processesWhite fatN-acetylglucosamine (O-GlcNAc) modificationOrexigenic AgRP neuronsVoltage-dependent potassium channelsCellular processesGlcNAc transferaseDynamic physiological processesNuclear proteinsWhite adipose tissue browningPhysiological processesAdipose tissue browningDiet-induced obesityPhysiological relevanceTissue browningGenetic ablationBeige cellsEnergy metabolismInsulin resistanceNeuronal excitabilityPotassium channelsAdipose tissueCentral mechanismsNeurons
2006
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
Yang X, Downes M, Yu RT, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM. Nuclear Receptor Expression Links the Circadian Clock to Metabolism. Cell 2006, 126: 801-810. PMID: 16923398, DOI: 10.1016/j.cell.2006.06.050.Peer-Reviewed Original ResearchConceptsNuclear receptor expressionReceptor expressionFat-soluble hormoneBrown adipose tissueKey metabolic tissuesPeripheral circadian clocksGlucose metabolismAdipose tissueDietary lipidsThyroid hormonesMetabolic tissuesKey target genesSkeletal muscleOrphan receptorNuclear receptorsEnergy metabolismNovel roleBasal metabolismHormoneMetabolismReceptorsCircadian clockExpression profilesMouse nuclear receptorsCircadian entrainment