2022
Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested case-control studySymptomsCase-control studySerotonin
2021
Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain
Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf B, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett E, Jiang W. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain. EBioMedicine 2021, 74: 103701. PMID: 34826801, PMCID: PMC8626580, DOI: 10.1016/j.ebiom.2021.103701.Peer-Reviewed Original ResearchConceptsCannabis smokersActinomyces meyeriCannabis smokingCentral nervous systemOral pathobiontsChronic cannabis smokersMacrophage infiltrationCannabis use disorderOral microbiomeOral microbial dysbiosisSaliva microbiomeNon-smoking controlsIncreased macrophage infiltrationCannabis exposureUse disorderMicrobial 16S rRNA sequencingCannabisCNS abnormalitiesProtein productionActinomyces odontolyticusOral bacteriaBehavioral changesNon-smokersMicrobial dysbiosisNervous system