Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome
Chen J, Zhao T, Li H, Xu W, Maas K, Singh V, Chen M, Dorsey S, Starkweather A, Cong X. Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome. International Journal Of Molecular Sciences 2024, 25: 3514. PMID: 38542485, PMCID: PMC10970623, DOI: 10.3390/ijms25063514.Peer-Reviewed Original ResearchConceptsGut microbiotaIrritable bowel syndrome subjectsHost transcriptomeIrritable bowel syndromeMetabolic pathways of gut microbiotaTranscriptome profilingAnalysis of gut microbiotaDysbiosis of gut microbiotaDysregulated immune responseRNA-seq dataHealthy controlsMulti-omics analysisImmune responseImmune system processRNA-seqGene OntologyBowel syndromeIBS participantsMulti-omicsMicrobiotaMetabolic pathwaysPathways of antigen processingPeripheral blood samplesGutStool samples