2024
Nurse-led self-management support to improve symptom management and self-reported outcomes in people with irritable bowel syndrome
Barandouzi Z, Chen J, Henderson W, Starkweather A, Cong X. Nurse-led self-management support to improve symptom management and self-reported outcomes in people with irritable bowel syndrome. Interdisciplinary Nursing Research 2024, 3 PMCID: PMC11567672, DOI: 10.1097/nr9.0000000000000069.Peer-Reviewed Original ResearchSelf-management sessionsQuality of lifeSelf-management supportSelf-management interventionsRegistered nursesSelf-reported outcomesPhysical activitySelf-managementSymptom managementIrritable bowel syndromeNurse-led supportImprove symptom managementImprove self-managementImprove dietary habitsSelf-management approachParent randomized controlled trialManagement of irritable bowel syndromeRandomized controlled trialsNurse-ledHigh-fat foodsParticipants' needsIn-personDietary habitsDisorders of gut-brain interactionSymptom episodesMulti-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome
Chen J, Zhao T, Li H, Xu W, Maas K, Singh V, Chen M, Dorsey S, Starkweather A, Cong X. Multi-Omics Analysis of Gut Microbiota and Host Transcriptomics Reveal Dysregulated Immune Response and Metabolism in Young Adults with Irritable Bowel Syndrome. International Journal Of Molecular Sciences 2024, 25: 3514. PMID: 38542485, PMCID: PMC10970623, DOI: 10.3390/ijms25063514.Peer-Reviewed Original ResearchConceptsGut microbiotaIrritable bowel syndrome subjectsHost transcriptomeIrritable bowel syndromeMetabolic pathways of gut microbiotaTranscriptome profilingAnalysis of gut microbiotaDysbiosis of gut microbiotaDysregulated immune responseRNA-seq dataHealthy controlsMulti-omics analysisImmune responseImmune system processRNA-seqGene OntologyBowel syndromeIBS participantsMulti-omicsMicrobiotaMetabolic pathwaysPathways of antigen processingPeripheral blood samplesGutStool samples
2022
Somatosensory Profiles Differentiate Pain and Psychophysiological Symptoms Among Young Adults With Irritable Bowel Syndrome
Chen J, Zhang Y, Barandouzi Z, Xu W, Feng B, Chon K, Santos M, Starkweather A, Cong X. Somatosensory Profiles Differentiate Pain and Psychophysiological Symptoms Among Young Adults With Irritable Bowel Syndrome. The Clinical Journal Of Pain 2022, 38: 492-501. PMID: 35686579, PMCID: PMC9205184, DOI: 10.1097/ajp.0000000000001046.Peer-Reviewed Original ResearchConceptsIrritable bowel syndromeIrritable bowel syndrome patientsHealthy controlsPain intensityPain thresholdBowel syndromeIBS-related painSomatic pain perceptionQuantitative sensory testingIncreased pain thresholdYoung adultsRandomized clinical trialsSelf-management interventionsSomatosensory profilesDifferentiate painPain perceptionPsychophysiological symptomsFollow-upClinical trialsPainNormal thresholdsIncreased thresholdSensory thresholdsSevere symptomsPatientsThe effect of self-management online modules plus nurse-led support on pain and quality of life among young adults with irritable bowel syndrome: A randomized controlled trial
Chen J, Zhang Y, Barandouzi Z, Lee J, Zhao T, Xu W, Chen M, Feng B, Starkweather A, Cong X. The effect of self-management online modules plus nurse-led support on pain and quality of life among young adults with irritable bowel syndrome: A randomized controlled trial. International Journal Of Nursing Studies 2022, 132: 104278. PMID: 35640500, PMCID: PMC10588769, DOI: 10.1016/j.ijnurstu.2022.104278.Peer-Reviewed Original ResearchConceptsQuality of lifeImprove quality of lifeNurse-led interventionNurse-ledIntervention groupIntervention effectsPain interferenceOnline modulesImprove qualitySelf-managementNurse-led self-management programIrritable bowel syndromeYoung adultsSelf-efficacyNurse-led supportEffects of self-managementLife-long self-managementSelf-management programReducing pain interferenceSelf-reported painFollow-upIncreased quality of lifeBaseline data collectionIncreased self-efficacyDecreased pain intensityAssociations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome
Barandouzi Z, Lee J, del Carmen Rosas M, Chen J, Henderson W, Starkweather A, Cong X. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome. Scientific Reports 2022, 12: 1648. PMID: 35102266, PMCID: PMC8803858, DOI: 10.1038/s41598-022-05756-0.Peer-Reviewed Original ResearchConceptsEmotional distressNeurotransmitter levelsHealthy controlsIrritable bowel syndrome groupIrritable bowel syndromeRegulation of neurotransmittersDepressive symptomsSerotonin levelsGut-brain axisEmotional symptomsHC groupPlasma neurotransmittersDistressGut microbiome profilesNeurotransmitterGut microbiomeNorepinephrine levelsBowel syndromeMicrobiome profilesPersonsNorepinephrineNested case-control studySymptomsCase-control studySerotoninThe Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome
Zhao T, Zhang Y, Lee J, Starkweather A, Young E, Cong X. The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome. Journal Of Personalized Medicine 2022, 12: 142. PMID: 35207633, PMCID: PMC8878682, DOI: 10.3390/jpm12020142.Peer-Reviewed Original ResearchAssociated with IBS riskPatient-Reported Outcomes Measurement Information SystemBrief Pain InventorySingle nucleotide polymorphismsPain severityIrritable bowel syndromeOutcomes Measurement Information SystemIrritable bowel syndrome symptomsAssociated with pain severityMeasurement Information SystemSleep disturbanceAssociated with fatigueRisk single nucleotide polymorphismsAssociation of single nucleotide polymorphismsAssociated with sleep disturbancesRandomized controlled trialsMultivariate linear regressionNucleotide polymorphismsPain InventoryBowel syndromeFisher's exact testHealthy controlsBaseline dataRisk allelesSymptoms of irritable bowel syndromePsychosocial and Sensory Factors Contribute to Self-Reported Pain and Quality of Life in Young Adults with Irritable Bowel Syndrome
Chen J, Barandouzi Z, Lee J, Xu W, Feng B, Starkweather A, Cong X. Psychosocial and Sensory Factors Contribute to Self-Reported Pain and Quality of Life in Young Adults with Irritable Bowel Syndrome. Pain Management Nursing 2022, 23: 646-654. PMID: 35074280, PMCID: PMC9300766, DOI: 10.1016/j.pmn.2021.12.004.Peer-Reviewed Original ResearchConceptsSelf-reported painQuality of lifePressure pain thresholdBrief Pain InventoryPsychosocial factorsSelf-efficacyPain interferenceIBS-QOLIrritable bowel syndromeAssociated with pain interferenceCross-sectional analysis of baseline dataPain thresholdAnalysis of baseline dataYoung adultsImprove pain managementMediation analysisCross-sectional analysisSensory factorsRandomized controlled trialsPain InventoryPain managementIntervention studiesAlcohol intakeCold pain thresholdGeneral community
2021
Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components
Barandouzi Z, Lee J, Maas K, Starkweather A, Cong X. Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components. Journal Of Personalized Medicine 2021, 11: 35. PMID: 33429936, PMCID: PMC7827153, DOI: 10.3390/jpm11010035.Peer-Reviewed Original ResearchAlpha diversity indicesGut microbiotaIrritable bowel syndromeDiversity indexHealthy controlsHighest alpha-diversity indicesAlterations of gut microbiota compositionGut microbiota patternHigher alpha diversityGut microbiota compositionGut microbiota alterationsAltered gut microbiotaGut microbiome patternsCaffeine consumptionBowel syndromePathophysiology of irritable bowel syndromeIllumina sequencingFood frequency questionnaireAlpha diversityIrritable bowel syndrome groupIrritable bowel syndrome patientsMicrobial diversityMicrobiota compositionMicrobiota alterationsMicrobiota patterns
2018
Pain self‐management plus nurse‐led support in young adults with irritable bowel syndrome: Study protocol for a pilot randomized control trial
Cong X, Ramesh D, Perry M, Xu W, Bernier K, Young E, Walsh S, Starkweather A. Pain self‐management plus nurse‐led support in young adults with irritable bowel syndrome: Study protocol for a pilot randomized control trial. Research In Nursing & Health 2018, 41: 121-130. PMID: 29388674, PMCID: PMC6415297, DOI: 10.1002/nur.21862.Peer-Reviewed Original ResearchConceptsQuality of lifeSM interventionsHealth outcomesSelf-managementIrritable bowel syndromeNurse-led supportSM behaviorSelf-management instructionsLongitudinal pilot studyYoung adultsPreliminary effectivenessPain neurophysiologyPhone consultationsDistressing symptomsEarly adult yearsBowel syndromePrimary outcomeStudy protocolVideo modulesWell-beingSeverity of symptomsPilot studyAdult yearsInterventionPain
2017
Effects of Self-Management Interventions in Patients With Irritable Bowel Syndrome: Systematic Review
Cong X, Perry M, Bernier K, Young E, Starkweather A. Effects of Self-Management Interventions in Patients With Irritable Bowel Syndrome: Systematic Review. Western Journal Of Nursing Research 2017, 40: 1698-1720. PMID: 28854852, PMCID: PMC5794643, DOI: 10.1177/0193945917727705.Peer-Reviewed Original ResearchConceptsSelf-management interventionsEffectiveness of self-management interventionsQuality of lifeIrritable bowel syndromeSymptom self-management strategiesSystematic reviewExercise-based interventionsMeasures of quality of lifeSelf-management strategiesHealth care providersTracking long-term outcomesImprove quality of lifeSymptom measuresSymptom managementCare providersGroup interventionCognitive-behavioral therapyBowel syndromeImprove qualityInterventionWeb-basedPediatric populationCost conditionsLong-term outcomesSymptoms