1999
Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site
Foley J, Wysolmerski J, Missero C, King C, Philbrick W. Regulation of parathyroid hormone-related protein gene expression in murine keratinocytes by E1A isoforms: a role for basal promoter and Ets-1 site. Molecular And Cellular Endocrinology 1999, 156: 13-23. PMID: 10612419, DOI: 10.1016/s0303-7207(99)00151-3.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus E1A ProteinsAnimalsBase SequenceBinding SitesCell Line, TransformedEnhancer Elements, GeneticGene Expression RegulationGenes, rasGenes, ReporterKeratinocytesLuciferasesMiceParathyroid HormoneParathyroid Hormone-Related ProteinPromoter Regions, GeneticProtein IsoformsProteinsProto-Oncogene Protein c-ets-1Proto-Oncogene ProteinsProto-Oncogene Proteins c-etsRNA, MessengerTranscription FactorsTranscription, GeneticConceptsGene expressionBasal promoterReporter constructsEts-1 siteMinimal promoter regionProtein gene expressionTransient transfection assaysReporter gene activityRepressor domainE1A oncoproteinGene activityRas transformationE1A isoformsMurine keratinocyte lineSite upstreamReporter geneTransfection assaysPromoter regionParathyroid hormone-related protein gene expression
1995
Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines
Orloff J, Kats Y, Urena P, Schipani E, Vasavada R, Philbrick W, Behal A, Abou-Samra A, Segre G, Jüppner H. Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines. Endocrinology 1995, 136: 3016-3023. PMID: 7789327, DOI: 10.1210/endo.136.7.7789327.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBlotting, NorthernCarcinoma, Squamous CellCyclic AMPDNA ProbesGene ExpressionHumansKeratinocytesMolecular Sequence DataParathyroid HormoneParathyroid Hormone-Related ProteinPeptide FragmentsProteinsRadioligand AssayReceptor, Parathyroid Hormone, Type 1Receptors, Parathyroid HormoneRNA, MessengerTransfectionTumor Cells, CulturedConceptsSquamous carcinoma cell linesSquamous cell linesPTH/PTHrP receptorType I receptorCarcinoma cell linesI receptorSquamous cellsPTHrP receptorCell linesCommon PTH/PTHrP receptorParathyroid hormone-related proteinType INormal keratinocytesAmino-terminal PTHMessenger RNAHormone-related proteinReceptor messenger RNAPTH target tissuesIntracellular cAMP responseSqCC/Y1 cellsSquamous carcinoma cellsStrong RNA signalsReceptor complementary DNAType II receptorIntracellular calcium
1990
The CD59 antigen is a structural homologue of murine Ly‐6 antigens but lacks interferon inducibility
Philbrick W, Palfree R, Maher S, Bridgett M, Sirlin S, Bothwell A. The CD59 antigen is a structural homologue of murine Ly‐6 antigens but lacks interferon inducibility. European Journal Of Immunology 1990, 20: 87-92. PMID: 1689664, DOI: 10.1002/eji.1830200113.Peer-Reviewed Original ResearchConceptsHydrophobic carboxy terminusSomatic cell hybridsLy-6 proteinsLy-6 moleculesNeural cell typesDifferent tissue distributionInterferon inducibilityLy-6 antigensSingle geneCell hybridsLimited homologyCD59 antigenLy-6ECarboxy terminusCysteine residuesProtein sequencesCOS cellsStructural homologuesLy-6C antigenModification sitesMessage speciesLy-6Human DNAMonkey cellsCell types