2000
Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade
Nakchbandi I, Weir E, Insogna K, Philbrick W, Broadus A. Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7296-7300. PMID: 10829073, PMCID: PMC16539, DOI: 10.1073/pnas.110553397.Peer-Reviewed Original ResearchConceptsNumber of osteoclastsEffects of PTHrPOsteoclast formationDF cellsBone resorptionFactor expressionOsteoclastic bone resorptionDental follicle cellsHormone-related proteinOsteoclast differentiation factorStellate reticulum cellsOsteoclastogenesis inhibitory factorCoronal tooth surfacesSpontaneous osteoclast formationParacrine cascadeParathyroid hormoneEruption pathwayReticulum cellsPeripheral skeletonTooth eruptionOsteoclast precursorsPTH/PTHrP.Inhibitory factorFunctional osteoclastsCrypt cells
1998
Parathyroid hormone-related protein is required for tooth eruption
Philbrick W, Dreyer B, Nakchbandi I, Karaplis A. Parathyroid hormone-related protein is required for tooth eruption. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11846-11851. PMID: 9751753, PMCID: PMC21728, DOI: 10.1073/pnas.95.20.11846.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceTooth eruptionEruption pathwayPTHrP expressionType I PTH/PTHrP receptorEnamel epitheliumPTH/PTHrP receptorOverexpression of PTHrPHormone-related proteinMonths of ageNormal tooth developmentParathyroid hormoneBone resorptionPTHrP receptorPTHrP mRNAKnockout miceTransgenic miceAlveolar boneDental mesenchymeLevel of expressionMiceBone formationSkeletal abnormalitiesTooth developmentKeratin 14