PTHrP Regulates Epidermal Differentiation in Adult Mice
Foley J, Wysolmerski J, Dreyer B, Broadus A, Philbrick W, Longely B. PTHrP Regulates Epidermal Differentiation in Adult Mice. Journal Of Investigative Dermatology 1998, 111: 1122-1128. PMID: 9856827, DOI: 10.1046/j.1523-1747.1998.00428.x.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceKeratin 14 promoterAdult miceSebaceous glandsHuman keratin 14 promoterParathyroid hormone-related peptideHyperplastic sebaceous glandsHormone-related peptideAbsence of PTHrPNumber of organsWk of agePremature acquisitionEpidermal proliferation rateMarked acanthosisTransgenic replacementReciprocal findingsTransgenic micePTHrPPTHrP geneMiceMammary glandBasal keratinocytesDisplay abnormalitiesLethal chondrodystrophyFibrotic dermisParathyroid hormone-related protein is required for tooth eruption
Philbrick W, Dreyer B, Nakchbandi I, Karaplis A. Parathyroid hormone-related protein is required for tooth eruption. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11846-11851. PMID: 9751753, PMCID: PMC21728, DOI: 10.1073/pnas.95.20.11846.Peer-Reviewed Original ResearchConceptsPTHrP-knockout miceTooth eruptionEruption pathwayPTHrP expressionType I PTH/PTHrP receptorEnamel epitheliumPTH/PTHrP receptorOverexpression of PTHrPHormone-related proteinMonths of ageNormal tooth developmentParathyroid hormoneBone resorptionPTHrP receptorPTHrP mRNAKnockout miceTransgenic miceAlveolar boneDental mesenchymeLevel of expressionMiceBone formationSkeletal abnormalitiesTooth developmentKeratin 14