2023
Mechanisms of liver fibrosis in metabolic syndrome
Mehal W. Mechanisms of liver fibrosis in metabolic syndrome. EGastroenterology 2023, 1: e100015. PMID: 37946713, PMCID: PMC10634657, DOI: 10.1136/egastro-2023-100015.Peer-Reviewed Original ResearchNon-alcoholic steatohepatitisLiver fibrosisMetabolic syndromeHepatic stellate cellsHepatocellular injuryImmune systemHSC transdifferentiationGrowth factorChronic hepatocellular injuryInnate immune cellsMetabolite changesInnate immune systemAdaptive immune systemNASH fibrosisHepatocellular damageAntifibrotic strategiesImmune cellsProfibrotic roleT cellsFree fatty acidsStellate cellsViral infectionFibrosisSyndromeEndothelial cells
2020
Nonalcoholic Fatty Liver Disease in the Post Liver Transplant Patient
Batisti J, Mehal W. Nonalcoholic Fatty Liver Disease in the Post Liver Transplant Patient. Current Transplantation Reports 2020, 7: 332-339. DOI: 10.1007/s40472-020-00303-0.Peer-Reviewed Original ResearchFatty liver diseaseLiver transplantNonalcoholic steatohepatitisLiver diseasePost liver transplant patientsReviewNonalcoholic fatty liver diseaseNonalcoholic fatty liver diseaseManagement of immunosuppressionManagement of NAFLDPost-transplant populationLiver transplant patientsPost-transplant periodExcess weight gainRecent FindingsRecent studiesGraft steatosisNAFLD interventionGraft fibrosisHepatic manifestationRecurrent diseaseTransplant patientsMetabolic syndromeMedical managementRecipient factorsInsulin resistanceLT population
2018
Role of sterile inflammation in fatty liver diseases
Chen Y, Yousaf M, Mehal W. Role of sterile inflammation in fatty liver diseases. Liver Research 2018, 2: 21-29. DOI: 10.1016/j.livres.2018.02.003.Peer-Reviewed Original ResearchNon-alcoholic steatohepatitisSterile inflammationInflammatory responseTissue damageRegulatory T cellsFatty liver diseaseAnti-inflammatory effectsHepatic inflammatory responseAcute phase reactantsHigh-fat dietPropagation of inflammationSinusoidal endothelial cellsPro-inflammatory damageTrans retinoic acidGrowth factor βLiver inflammationMetabolic syndromeLiver diseaseIL-1βInflammatory cytokinesFat dietAlcohol excessFemale micePhase reactantsT cells