2024
Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy
Akiyama S, St-Pierre J, Traboulsi C, Silfen A, Rai V, Rodriguez T, Erondu A, Steinberg J, Shaffer S, Christensen B, Rubin D. Patients with ulcerative colitis who have normalized histology are clinically stable after de-escalation of therapy. Npj Gut And Liver 2024, 1: 5. DOI: 10.1038/s44355-024-00005-9.Peer-Reviewed Original ResearchHistologic normalizationUlcerative colitisDe-escalationUC patientsDe-escalation of therapyTherapeutic de-escalationMedian follow-upDe-escalation groupProportion of patientsStudy assessed outcomesHistological recurrenceRecurrence rateSingle-centerClinical stabilityTherapeutic changeRemission outcomesFollow-upTherapyPatientsImmunomodulationAminosalicylatesWithdrawalColitisMonthsOutcomesA Comparative Analysis of Clinical Symptoms and Modified Pouchitis Disease Activity Index Among Endoscopic Phenotypes of the J Pouch in Patients With Inflammatory Bowel Disease
Akiyama S, Cohen N, Ollech J, Traboulsi C, Rodriguez T, Rai V, Glick L, Yi Y, Runde J, Cohen R, Skowron K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. A Comparative Analysis of Clinical Symptoms and Modified Pouchitis Disease Activity Index Among Endoscopic Phenotypes of the J Pouch in Patients With Inflammatory Bowel Disease. Crohn's & Colitis 360 2024, 6: otae045. PMID: 39347443, PMCID: PMC11438232, DOI: 10.1093/crocol/otae045.Peer-Reviewed Original ResearchModified Pouchitis Disease Activity IndexPouchitis Disease Activity IndexInflammatory bowel diseasePouch-related fistulasDisease activity indexEndoscopic phenotypesComparative analysis of clinical symptomsInflammatory phenotypeClinical symptomsFocal inflammationAfferent limbComplete-case analysisBowel diseaseAnalysis of clinical symptomsActivity indexInflammatory bowel disease patientsAssess symptomsComplete-caseIncomplete emptyingPouch bodyNormal pouchEndoscopic findingsDiagnosing pouchitisDiffuse inflammationPerianal symptomsEndoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease
Akiyama S, Ollech J, Cohen N, Traboulsi C, Rai V, Glick L, Yi Y, Runde J, Cohen R, Olortegui K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2024, izae106. PMID: 38916136, DOI: 10.1093/ibd/izae106.Peer-Reviewed Original ResearchPouch-related fistulasInflammatory bowel diseaseNormal pouchDiffuse inflammationFocal inflammationAfferent limbBowel diseaseAssociated with favorable outcomesIleal pouch-anal anastomosisPouch-anal anastomosisPouch lossEndoscopic phenotypesIleostomy takedownFavorable outcomePouch inflammationPouch excisionPouch phenotypesPrimary phenotypeFistulaEndoscopic classificationInflammationPatientsPouch bodyCuffitisPhenotypic transition
2023
The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion
Onuchic L, Padovano V, Schena G, Rajendran V, Dong K, Shi X, Pandya R, Rai V, Gresko N, Ahmed O, Lam T, Wang W, Shen H, Somlo S, Caplan M. The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion. Nature Communications 2023, 14: 1790. PMID: 36997516, PMCID: PMC10063565, DOI: 10.1038/s41467-023-37449-1.Peer-Reviewed Original ResearchConceptsPolycystin-1Nicotinamide nucleotide transhydrogenaseTerminal tailCystic phenotypeAutosomal dominant polycystic kidney diseaseCyst cell proliferationC-terminal domainAmino acid residuesLethal monogenic disorderC-terminal cleavageNucleotide transhydrogenaseAcid residuesMitochondrial functionTransgenic expressionPKD1 geneRedox stateShort fragmentsCell proliferationMonogenic disordersDominant polycystic kidney diseasePolycystic kidney diseaseGene therapy strategiesProteinPhenotypeFragments
2022
Recommendations on the Appropriate Management of Steroids and Discharge Planning During and After Hospital Admission for Moderate-Severe Ulcerative Colitis: Results of a RAND Appropriateness Panel
Dulai P, Rai V, Raffals L, Lukin D, Hudesman D, Kochhar G, Damas O, Sauk J, Levy A, Sofia M, Tuskey A, Deepak P, Yarur A, Afzali A, Ananthakrishnan A, Cross R, Hanauer S, Siegel C. Recommendations on the Appropriate Management of Steroids and Discharge Planning During and After Hospital Admission for Moderate-Severe Ulcerative Colitis: Results of a RAND Appropriateness Panel. The American Journal Of Gastroenterology 2022, 117: 1288-1295. PMID: 35416799, PMCID: PMC9437635, DOI: 10.14309/ajg.0000000000001775.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsModerate-severe flaresUlcerative colitisAntitumor necrosis factor therapyModerate-severe ulcerative colitisNecrosis factor therapyRAND appropriateness panelMethylprednisolone 40Naive patientsPostdischarge managementSteroid dosingStool frequencyRectal bleedingTherapy initiationAdverse eventsFactor therapyInpatient managementPostdischarge careHospital admissionLower endoscopyDischarge planningLower riskPatientsDischarge criteriaAppropriate managementHigh dosesHistopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis
Akiyama S, Ollech J, Traboulsi C, Rai V, Glick L, Yi Y, Runde J, Olivas A, Weber C, Cohen R, Olortegui K, Hurst R, Umanskiy K, Shogan B, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Hart J, Hyman N, Rubin D. Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis. Digestive Diseases And Sciences 2022, 67: 4020-4031. PMID: 35288827, PMCID: PMC10966959, DOI: 10.1007/s10620-022-07405-y.Peer-Reviewed Original ResearchConceptsIleal pouch-anal anastomosisUlcerative colitisColectomy specimensTerminal ileal involvementCrohn's diseaseIleal involvementPouch fistulaFocal inflammationDeep inflammationLimb involvementPouch-anal anastomosisLogistic regression analysisIleostomy takedownPouch bodyPouch lossEndoscopic appearancePathology reviewMultivariable analysisHistologic featuresPoor prognosisPathological dataEndoscopic phenotypesHigh riskPatientsInflammationOutcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch–Anal Anastomosis in Pediatric Ulcerative Colitis
Runde J, Erondu A, Akiyama S, Traboulsi C, Rai V, Glick L, Yi Y, Ollech J, Cohen R, Skowron K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch–Anal Anastomosis in Pediatric Ulcerative Colitis. Inflammatory Bowel Diseases 2022, 28: 1386-1394. PMID: 35040964, PMCID: PMC9434476, DOI: 10.1093/ibd/izab319.Peer-Reviewed Original ResearchConceptsIleal pouch-anal anastomosisPediatric ulcerative colitisPouch-anal anastomosisUlcerative colitisYears of agePouch survivalAdult patientsRetrospective single-center studyIleoanal pouch anastomosisAnti-TNF therapySingle-center studyKaplan-Meier curvesLog-rank testKaplan-Meier estimatesPediatric control subjectsElectronic medical recordsChi-square testPouch anastomosisPouch failureTotal proctocolectomyPediatric patientsSurgical outcomesControl subjectsMedical recordsRapid progression
2021
Ulcerative Colitis Patients Have Reduced Rectal Compliance Compared With Non–Inflammatory Bowel Disease Controls
Krugliak Cleveland N, Rai V, El Jurdi K, Rao S, Giurcanu M, Rubin D. Ulcerative Colitis Patients Have Reduced Rectal Compliance Compared With Non–Inflammatory Bowel Disease Controls. Gastroenterology 2021, 162: 331-333.e1. PMID: 34597674, PMCID: PMC8678316, DOI: 10.1053/j.gastro.2021.09.052.Peer-Reviewed Original ResearchIdentification of Risk Factors for Coexisting Sinusitis and Inflammatory Bowel Disease
Rai V, Traboulsi C, Silfen A, Ackerman M, Erondu A, Karpin J, Gulotta G, Rubin D. Identification of Risk Factors for Coexisting Sinusitis and Inflammatory Bowel Disease. Crohn's & Colitis 360 2021, 3: otab054. PMID: 35531367, PMCID: PMC9075692, DOI: 10.1093/crocol/otab054.Peer-Reviewed Original ResearchDuration of diseaseSteroid exposureChronic sinusitis diagnosisRisk of sinusitisSingle-center studyInflammatory bowel diseaseClinical trial dataLogistic regression analysisWilcoxon rank sum testRank sum testSinusitis diagnosisSubsequent sinusitisExtraintestinal manifestationsMaintenance therapyIBD diagnosisAdverse eventsBowel diseaseUC diagnosisMultivariable analysisRisk factorsSinusitisPatientsSubsequent diseaseTrial dataYounger ageAchieving Histologic Normalization in Ulcerative Colitis Is Associated With a Reduced Risk of Subsequent Dysplasia
Shaffer S, Erondu A, Traboulsi C, Rai V, Cleveland N, Israel A, Christensen B, Rubin D. Achieving Histologic Normalization in Ulcerative Colitis Is Associated With a Reduced Risk of Subsequent Dysplasia. Inflammatory Bowel Diseases 2021, 28: 553-559. PMID: 34037230, PMCID: PMC9122749, DOI: 10.1093/ibd/izab130.Peer-Reviewed Original ResearchConceptsPersistent histologic activityHistologic normalizationUlcerative colitisHistologic activityUC diagnosisSubsequent dysplasiaIncidence rateDysplasia developmentDiagnosis of UCCox regression analysisKaplan-Meier graphsImproved clinical outcomesDevelopment of dysplasiaHistologic inflammationUC durationDysplasia ratesDisease courseTertiary centerClinical outcomesDecreased riskPatient groupSurveillance intervalsHistologic assessmentRetrospective analysisReduced riskUsing Wearable Biosensors to Predict Length of Stay for Patients with IBD After Bowel Surgery
Yi Y, Sossenheimer P, Erondu A, Skowron K, Rai V, Singer J, El Jurdi K, Hyman N, Rubin D. Using Wearable Biosensors to Predict Length of Stay for Patients with IBD After Bowel Surgery. Digestive Diseases And Sciences 2021, 67: 844-853. PMID: 33761092, PMCID: PMC8564769, DOI: 10.1007/s10620-021-06910-w.Peer-Reviewed Original ResearchConceptsLength of stayPostoperative day 2Postoperative day 4Multivariable linear regression modelsPostoperative lengthSleep efficiencySleep durationDay 2Day 4Clavien-Dindo grade 1Postoperative day 1More severe complicationsPostoperative day 5Short sleep durationHigher sleep efficiencyLinear regression modelsBowel surgerySevere complicationsRegression modelsShorter lengthDaily stepsDay 1PatientsStayDay 5Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes
Akiyama S, Ollech J, Rai V, Glick L, Yi Y, Traboulsi C, Runde J, Cohen R, Skowron K, Hurst R, Umanskiy K, Shogan B, Hyman N, Rubin M, Dalal S, Sakuraba A, Pekow J, Chang E, Rubin D. Endoscopic Phenotype of the J Pouch in Patients With Inflammatory Bowel Disease: A New Classification for Pouch Outcomes. Clinical Gastroenterology And Hepatology 2021, 20: 293-302.e9. PMID: 33549868, PMCID: PMC8339185, DOI: 10.1016/j.cgh.2021.02.010.Peer-Reviewed Original ResearchConceptsIleal pouch-anal anastomosisDiffuse inflammationPouch excisionSignificant contributing factorLimb involvementAnti-tumor necrosis factor drugsCox proportional hazards modelPouch-anal anastomosisFuture interventional studiesInflammatory bowel diseasePattern of inflammationHand-sewn anastomosisBody mass indexClostridioides difficile infectionLog-rank testContributing factorProportional hazards modelLogistic regression analysisEndoscopic patternsExtensive colitisIleostomy takedownPouch bodyPouch survivalBowel diseaseCommon complicationTHE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS
Akiyama S, Ollech J, Rai V, Yi Y, Traboulsi C, Glick L, Runde J, Cohen R, Hurst R, Hyman N, Dalal S, Sakuraba A, Pekow J, Rubin D. THE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS. Gastroenterology 2021, 160: s61-s62. DOI: 10.1053/j.gastro.2021.01.158.Peer-Reviewed Original ResearchA Practical Clinical Approach to the Management of High-Risk Ulcerative Colitis.
Rubin D, Traboulsi C, Rai V. A Practical Clinical Approach to the Management of High-Risk Ulcerative Colitis. Gastroenterology & Hepatology 2021, 17: 59-66. PMID: 34035764, PMCID: PMC8132723.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUlcerative colitisDisease activityRecurrent disease activityLong-term remissionManagement of patientsGoal of treatmentPractical clinical approachPatient's risk levelRange of symptomsAbdominal painRectal bleedingFulminant diseasePrognostic factorsSurgical optionsTherapeutic choiceInpatient settingPatientsClinical approachDrug mechanismsDisease responseRemissionColitisTreatmentObjective measuresCritical appraisalTHE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS
Akiyama S, Ollech J, Rai V, Yi Y, Traboulsi C, Glick L, Runde J, Cohen R, Hurst R, Hyman N, Dalal S, Sakuraba A, Pekow J, Rubin D. THE CLINICAL FEATURES AND PROGNOSTIC VALUE OF INFLAMMATORY POLYPS IN THE J POUCH OF PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED BY PROCTOCOLECTOMY WITH ILEAL POUCH-ANAL ANASTOMOSIS. Inflammatory Bowel Diseases 2021, 27: s45-s45. DOI: 10.1093/ibd/izaa347.109.Peer-Reviewed Original ResearchIleal pouch-anal anastomosisInflammatory bowel diseaseAnti-TNF drugsInflammatory polypsPouch-anal anastomosisKaplan-Meier curvesJ-pouchIBD patientsPouch excisionEndoscopic findingsBowel diseaseRectal cuffDistal pouchRetrospective single-center studyCommon anatomical locationSingle-center studyLog-rank testErythema/edemaLogistic regression analysisDifferent anatomic areasRefractory colitisChronic pouchitisBackground PatientsTotal proctocolectomyIndependent predictorsSARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting
Siegel C, Melmed G, McGovern D, Rai V, Krammer F, Rubin D, Abreu M, Dubinsky M, Ahuja V, Allez M, Ananthakrishnan A, Bernstein C, Braun J, Chowers Y, Colombel J, Danese S, Dignass A, Dotan I, Fleshner P, Gasche C, Gearry R, Ghosh S, Griffiths A, Hanauer S, Hart A, Kaplan G, Kaser A, Kotze P, Koutroubakis I, Kruis W, Lakatos P, Levine A, Lewis J, Lindsay J, Loftus E, Louis E, Lukas M, Magro F, Mahadevan U, Mantzaris G, Moum B, Munkholm P, Ng S, O’Morain C, Oresland T, Panaccione R, Panes J, Pemberton J, Prantera C, Ran Z, Reinisch W, Rogler G, Sandborn W, Sands B, Sartor B, Schölmerich J, Siegmund B, Silverberg M, Sood A, Spinelli A, Steinwurz F, Travis S, Turner D, Tysk C, Vatn M, Vermeire S, Yamamoto T, Yamamoto-Furusho J, Panis Y. SARS-CoV-2 vaccination for patients with inflammatory bowel diseases: recommendations from an international consensus meeting. Gut 2021, 70: 635-640. PMID: 33472895, PMCID: PMC7818789, DOI: 10.1136/gutjnl-2020-324000.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAssessment of Comorbid Depression and Anxiety in Inflammatory Bowel Disease Using Adaptive Testing Technology
Karpin J, Rodriguez T, Traboulsi C, Rai V, Gibbons R, Rubin D. Assessment of Comorbid Depression and Anxiety in Inflammatory Bowel Disease Using Adaptive Testing Technology. Crohn's & Colitis 360 2021, 3: otaa095. PMID: 34746788, PMCID: PMC8570563, DOI: 10.1093/crocol/otaa095.Peer-Reviewed Original ResearchInflammatory bowel diseaseBowel diseaseExact testActive inflammatory bowel diseaseClinical remission statusNegative CRP valuesMental health screeningPearson's chi-square testFisher's exact testMental health conditionsChi-square testCAT-MHIBD clinicIBD patientsPositive CRPUndiagnosed anxietyClinical remissionDisease activityIBD populationPatient characteristicsConsecutive patientsCRP valuesMultivariable analysisSignificant positive associationRemission status
2020
Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment
Akiyama S, Rai V, Rubin D. Pouchitis in inflammatory bowel disease: a review of diagnosis, prognosis, and treatment. Intestinal Research 2020, 19: 1-11. PMID: 33138344, PMCID: PMC7873408, DOI: 10.5217/ir.2020.00047.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIleal pouch-anal anastomosisInflammatory bowel diseaseBowel diseaseRisk factorsUlcerative colitis patientsPouch-anal anastomosisReview of diagnosisDysplasia/cancerNew biological agentsPouchitis developmentRefractory colitisColitis patientsPouch failureRestorative proctocolectomyPouch excisionCrohn's diseaseImpairs qualityTreatment optionsChronic conditionsPouchitisFrequent reasonPatientsDiseaseProctocolectomyPrognosisBlack Race and Public Insurance Are Predictive of Inappropriate Evaluation of Iron Deficiency Anemia and Diarrhea
Anyane-Yeboa A, Li B, Traboulsi C, Erondu A, Sossenheimer P, Rai V, Rubin D. Black Race and Public Insurance Are Predictive of Inappropriate Evaluation of Iron Deficiency Anemia and Diarrhea. Digestive Diseases And Sciences 2020, 66: 2200-2206. PMID: 32638203, DOI: 10.1007/s10620-020-06434-9.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIron deficiency anemiaAge-adjusted multivariate analysisAppropriate workupChronic diarrheaCeliac diseaseBlack raceDeficiency anemiaDiagnosis codesInsurance statusMultivariate analysisPublic insurancePublic insurance statusChronic disease statesChicago Medical CenterMethodsMedical recordsBowel diseaseResultsIn totalMedical CenterDiarrheaWorkupIron deficiencyLogistic regressionPatientsSeparate encountersManagement of Patients With Crohn’s Disease and Ulcerative Colitis During the Coronavirus Disease-2019 Pandemic: Results of an International Meeting
Rubin D, Abreu M, Rai V, Siegel C, Disease I, Ahuja V, Allez M, Ananthakrishnan A, Bernstein C, Braun J, Chowers Y, Colombel J, Danese S, D'Haens G, D'Hoore A, Dignass A, Dotan I, Dubinsky M, Ekbom A, Fleshner P, Gassull M, Gearry R, Ghosh S, Griffiths A, Halfvarson J, Hanauer S, Harpaz N, Hart A, Kamm M, Kaplan G, Koutroubakis I, Lakatos P, Levine A, Lewis J, Lindsay J, Loftus E, Louis E, Lukas M, Magro F, Mahadevan U, Mantzaris G, McGovern D, Moum B, Munkholm P, Neurath M, Ng S, O'Morain C, Panaccione R, Panes J, Peyrin-Biroulet L, Prantera C, Ran Z, Reinisch W, Remzi F, Sachar D, Sandborn W, Sartor R, Schölmerich J, Schreiber S, Siegmund B, Silverberg M, Söderholm J, Stange E, Steinwurz F, Turner D, Vatn M, Vermeire S, Brenner E, Christensen B, D'Amico F, Griffiths C, Higgins P, Kappelman M, Lees C, Regueiro M, Rosh J, Ungaro R. Management of Patients With Crohn’s Disease and Ulcerative Colitis During the Coronavirus Disease-2019 Pandemic: Results of an International Meeting. Gastroenterology 2020, 159: 6-13.e6. PMID: 32272113, PMCID: PMC7194599, DOI: 10.1053/j.gastro.2020.04.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements