Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation
Goldstein J, Fletcher S, Roth E, Wu C, Chun A, Horsley V. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation. Genes & Development 2014, 28: 983-994. PMID: 24732379, PMCID: PMC4018496, DOI: 10.1101/gad.236554.113.Peer-Reviewed Original ResearchConceptsStem cell quiescenceStem cell nicheHair follicle (HF) SCsTranscription factor nuclear factorJAK/STAT5Hormonal signalingMolecular circuitryActivated T cells c1Phosphatase calcineurinCell nicheSC quiescenceCell quiescenceT cells c1Calcineurin/NFATc1Function experimentsGenetic changesCanonical activationPharmacological lossPRL injectionsSC activationProlactin receptorMost tissuesTissue environmentHF SCsNuclear factorAdipocytes in Skin Health and Disease
Rivera-Gonzalez G, Shook B, Horsley V. Adipocytes in Skin Health and Disease. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015271. PMID: 24591537, PMCID: PMC3935392, DOI: 10.1101/cshperspect.a015271.Peer-Reviewed Original ResearchConceptsCutaneous biologyDermal adipocytesHair follicle growthTissue homeostasisDermal adipose tissueCellular basisRole of adipocytesAdipocytesHair cycleRegenerative capacityBiologyClinical manifestationsCutaneous diseaseReservoir of energyDermal compartmentAdipose tissueFollicle growthPotential roleSkin healthRecent studiesStructural supportWound healingDiseaseDynamic changesHomeostasis