2016
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis
Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis. Cell Stem Cell 2016, 19: 738-751. PMID: 27746098, PMCID: PMC5135565, DOI: 10.1016/j.stem.2016.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAnimalsCD24 AntigenCell ProliferationCell Self RenewalDermisGene Expression ProfilingHyperplasiaMice, Inbred C57BLModels, BiologicalPhosphatidylinositol 3-KinasesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor alphaSignal TransductionSkinStem CellsConceptsAdipocyte stem cellsAdipogenic programLipid-filled mature adipocytesStem Cell Self-RenewalCell Self-RenewalDistinct regulatory mechanismsASC proliferationPI3K/Akt2Stem cell populationWhite adipose tissueUnrecognized regulatorSelf-RenewalRegulatory mechanismsGenetic studiesMature adipocytesPDGFA expressionStem cellsCell populationsTissue growthProliferationActive mechanismDifferent WAT depotsHair growthMaintenanceAkt2
2008
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells. Cell 2008, 132: 299-310. PMID: 18243104, PMCID: PMC2546702, DOI: 10.1016/j.cell.2007.11.047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34BiomarkersCell NucleusCell ProliferationCells, CulturedCyclin-Dependent Kinase 4CyclosporineDown-RegulationEmbryo, MammalianGene DeletionGene ExpressionGene Expression Regulation, DevelopmentalGenes, ReporterHair FollicleImmunohistochemistryImmunosuppressive AgentsMiceMice, KnockoutMice, NudeMorphogenesisNFATC Transcription FactorsRetroviridaeRNA, MessengerSkinSkin TransplantationStem CellsTranscription FactorsTransgenesTransplantation, HomologousConceptsStem cellsHair growthCell quiescenceStem cell quiescenceExcessive hair growthFollicular growthNFATc1 signalingHair follicle stem cellsFollicle stem cellsGene ablationQuiescent adult stem cellsAdult stem cellsNFATc1Skin stem cellsFunctional roleCellsTissue homeostasisProliferationPatientsInjury