Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsThomas Kosten
Professor Adjunct, PsychiatryAbout
Research
Publications
2026
Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants.
Guidetti C, Papakostas G, Stahl S, Pani L, De Martin S, Mattarei A, Comai S, Kröger C, Champasa P, Gorodetzky C, Vocci F, Kosten T, Bushnell D, Kappler M, Folli F, Inturrisi C, Pappagallo M, Manfredi P, Fava M. Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants. International Clinical Psychopharmacology 2026 PMID: 41749468, DOI: 10.1097/yic.0000000000000618.Peer-Reviewed Original ResearchInadequate response to standard antidepressantsStandard antidepressantsDepressive disorderMontgomery-Asberg Depression Rating ScaleSevere depressionPost Hoc AnalysisDepression Rating ScaleHigher baseline severityAdjunctive treatmentPhase 3 trialPrimary endpointHoc AnalysisPost hoc exploratory analysisBaseline MADRSDepression severityREL-1017Baseline severityRating ScaleMADRSBaseline scoresDepressionPer-protocol resultsExploratory analysisAntidepressantsMean changeBiological insights into schizophrenia from ancestrally diverse populations
Bigdeli T, Chatzinakos C, Bendl J, Barr P, Venkatesh S, Gorman B, Clarence T, Genovese G, Iyegbe C, Peterson R, Kolokotronis S, Burstein D, Meyers J, Li Y, Natarajan S, Francis M, Rajeevan N, Cheung K, DeLisi L, Kosten T, Zhao H, Achtyes E, Buckley P, Malaspina D, Lehrer D, Rapaport M, Braff D, Pato M, Fanous A, Pato C, Huang G, Muralidhar S, Gaziano J, Pyarajan S, Girdhar K, Lee D, Hoffman G, Aslan M, Fullard J, Voloudakis G, Harvey P, Roussos P. Biological insights into schizophrenia from ancestrally diverse populations. Nature 2026, 651: 404-413. PMID: 41565822, DOI: 10.1038/s41586-025-10000-6.Peer-Reviewed Original ResearchConceptsPopulations of African ancestryBiological insightsStatistical fine-mappingAfrican ancestryGenetically diverse populationsAfrican populationsIntegrative transcriptomic analysisElectronic health recordsDiverse populationsFine-mappingGenetic architectureGenomic dataPolygenic basisSchizophrenia geneticsTranscriptome analysisConsensus genesRate of diagnosisHealth disparitiesHealth recordsComprehensive assessmentBlack individualsRecruitment biasDisease biologyGenesAncestry
2025
Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases
Stratford J, Carnes M, Willis C, Minto M, Elnimeiry L, Mathur R, Schu M, Quach B, Carter J, Nolen T, Vandergrift N, Kosten T, Johnson E, Webb B. Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases. Translational Psychiatry 2025, 15: 528. PMID: 41271629, PMCID: PMC12711988, DOI: 10.1038/s41398-025-03721-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesProtein-protein interactionsDrug repurposing studiesTherapeutic Target DatabaseGenome-wide association study risk lociProtein-protein interaction networkGene expressionMulti-omics data integrationRepurposing studiesOpioid use disorderNetwork analysisRisk lociAssociation studiesProtein-proteinDGE analysisTarget genesOpen TargetsUse disorderGenesStatistically significant supportPost-mortem human brainOpiate use disorderBiological evidenceTarget databaseAvailable pharmacotherapiesMitigating Post-Traumatic Stress Disorder Risk Through Gender-Sensitive Trauma-Informed Care in the Emergency Department—A Narrative Review
Larsen S, Davis J, Murphy N, Moukaddam N, Swann A, Kosten T, Hundt N, Verrico C, Elechi O, Thomas Y. Mitigating Post-Traumatic Stress Disorder Risk Through Gender-Sensitive Trauma-Informed Care in the Emergency Department—A Narrative Review. Journal Of Emergency Medicine 2025, 80: 241-251. PMID: 41319493, DOI: 10.1016/j.jemermed.2025.10.035.Peer-Reviewed Original ResearchTrauma-informed carePost-traumatic stress disorderEmergency departmentPost-traumatic stress disorder riskED settingED workflowElectronic health record promptsTrauma-informed care practicesStress disorderTrauma-informed care approachMental health servicesNarrative reviewChronic post-traumatic stress disorderPractice communication techniquesPatient riskPlain language explanationsTrauma patientsPTSD incidenceIntrusive re-experiencingAcute stress disorderNarrative literature reviewAdult trauma patientsED careReferral pathwaysWeb of ScienceReasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides.
De Martin S, Comai S, Mattarei A, Kosten T, Vocci F, Gorodetzky C, Pappagallo M, Manfredi P. Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides. The Journal Of Clinical Psychiatry 2025, 86 PMID: 40965842, DOI: 10.4088/jcp.25lr15973a.Peer-Reviewed Original ResearchPharmacokinetic Interactions Between Ethanol and PT150, a Selective Glucocorticoid Receptor Antagonist, in Healthy Volunteers.
Vaughan A, Mensah C, Pennycuff J, Venneman S, Risborough V, Baker D, Nowak K, Williams R, Nolen T, Kosten T, Verrico C. Pharmacokinetic Interactions Between Ethanol and PT150, a Selective Glucocorticoid Receptor Antagonist, in Healthy Volunteers. Journal Of Addiction Medicine 2025 PMID: 40794488, DOI: 10.1097/adm.0000000000001557.Peer-Reviewed Original ResearchAlcohol use disorderGlucocorticoid receptor antagonistUse disorderArea under the concentration-time curveDrug-drug interaction studiesReceptor antagonistFifth dosePharmacokinetic interactionsCompetitive glucocorticoid receptor antagonistEthanol pharmacokineticsOral ethanolEthanol exposureMichael E. DeBakey Veterans Affairs Medical CenterTerminal elimination half-lifePT150Medication developmentSerious adverse eventsVeterans Affairs Medical CenterHealthy participantsConcentration-time curveElimination half-lifeAffairs Medical CenterAbnormal electrocardiogramAdverse eventsHealthy volunteersUnderstanding traumatic injuries and suicide risk: A conceptual exploration for the emergency department
Thomas Y, Swann A, Murtaza S, Kosten T, Murphy N, Mathew S, Verrico C, Davis J, Moukaddam N. Understanding traumatic injuries and suicide risk: A conceptual exploration for the emergency department. Journal Of Affective Disorders 2025, 391: 119977. PMID: 40721143, DOI: 10.1016/j.jad.2025.119977.Peer-Reviewed Original ResearchConceptsEmergency departmentSuicide riskResponse to chronic stressEarly identification of at-risk individualsSocietal burdenContinuum of careSustained psychosocial supportEvidence-based interventionsIdentification of at-risk individualsDigital health technologiesBurden of suicideTrauma-informed careBehavioral sensitizationTrauma exposureAt-risk individualsEarly identificationSuicidal behaviorSuicide attemptsTraumatic injuryChronic stressPsychosocial supportCare pathwaysED presentationsPsychological traumaSuicideThe association between cannabis use and suicidal intensity in psychiatric inpatients
Oladunjoye A, Swann A, Kosten T, Patriquin M, Bigdeli T, Barr P, Wilkinson A, Harding M, Nielsen D, Graham D. The association between cannabis use and suicidal intensity in psychiatric inpatients. American Journal On Addictions 2025, 34: 506-516. PMID: 40349103, DOI: 10.1111/ajad.70047.Peer-Reviewed Original ResearchSuicidal ideation intensityCannabis usePsychiatric inpatientsPsychological flexibilityColumbia-Suicide Severity Rating ScaleAssociated with cannabis useSuicidal intensityMale psychiatric inpatientsSubstance Involvement Screening TestSeverity Rating ScaleModel of moderationEmotion regulationPsychiatric comorbidityPolygenic risk scoresPath analysis modelSuicidal ideationSuicide attemptsRating ScaleSex-specific patternsPotential mediatorsSuicideInpatientsAssociated with greater riskCannabisAdolescentsNitrate ameliorates alcohol-induced cognitive impairment via oral microbiota
Li X, Ni Z, Shi W, Zhao K, Zhang Y, Liu L, Wang Z, Chen J, Yu Z, Gao X, Qin Y, Zhao J, Peng W, Shi J, Kosten T, Lu L, Su L, Xue Y, Sun H. Nitrate ameliorates alcohol-induced cognitive impairment via oral microbiota. Journal Of Neuroinflammation 2025, 22: 106. PMID: 40234914, PMCID: PMC12001487, DOI: 10.1186/s12974-025-03439-x.Peer-Reviewed Original ResearchConceptsAlcohol-induced cognitive impairmentCognitive impairmentLevel of cognitive impairmentAssociated with cognitive impairmentChronic alcohol exposureAssociated with higher cognitive impairmentHigher cognitive impairmentOral microbiotaAlcohol exposureCognitive functionBrain functionCognitive declineAlcohol useImpairmentAlcohol consumptionBeneficial effectsGerm-free miceAlcohol drinkersOral nitratesAlcoholDysregulated inflammationNeuroinflammationMetabolism-related bacteriaDrinkersMiceInteracting immediate and long-term action regulation in suicidal behavior
Murphy N, Kypriotakis G, Lijffijt M, Iqbal S, Iqbal T, Amarneh D, O’Brien B, Tamman A, Thomas Y, Moukaddam N, Kosten T, Averill L, Mathew S, Swann A. Interacting immediate and long-term action regulation in suicidal behavior. Journal Of Mood And Anxiety Disorders 2025, 10: 100118. PMID: 40657602, PMCID: PMC12244047, DOI: 10.1016/j.xjmad.2025.100118.Peer-Reviewed Original ResearchImmediate memory taskInternal State ScaleLifetime cumulative adversityChildhood traumaSuicidal behaviorAction regulationSuicidal ideationSuicide attemptsTreatment of suicide riskSSI-WConventional psychiatric diagnosesSevere suicide attemptsRegulation of actionsPsychiatric controlsMemory taskAddictive behaviorsPsychiatric diagnosisEarly traumaSuicide riskSuicidal crisisBehavioral symptomsStimulus discriminationCumulative adversityState scaleSuicide