2020
Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort
Lewis MD, Talluri J, Wilcox CM, Abberbock JN, Tang G, Conwell DL, Banks PA, Cote GA, Sherman S, Alkaade S, Gardner TB, Anderson MA, Sandhu BS, Muniraj T, Forsmark CE, Guda N, Gelrud A, Romagnuolo J, Brand R, LaRusch J, Amann ST, Slivka A, Whitcomb DC, Yadav D. Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort. Clinical Gastroenterology And Hepatology 2020, 19: 349-357. PMID: 32240833, PMCID: PMC7529676, DOI: 10.1016/j.cgh.2020.03.047.Peer-Reviewed Original ResearchConceptsOnset of symptomsModerate alcohol drinkersNorth American cohortAlcohol drinkersAge of onsetAmerican cohortAlcohol useChronic pancreatitisClinical featuresLate-onset idiopathic chronic pancreatitisNorth American Pancreatitis Study 2Genetic variantsEarly-onset ICPLate-onset ICPQuarter of patientsHalf of patientsIdiopathic chronic pancreatitisHigher proportionHeavy alcohol useCross-sectional analysisICP symptomsConstant painMedian ageAvailable patientsProspective study
2017
Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities
Machicado JD, Amann ST, Anderson MA, Abberbock J, Sherman S, Conwell DL, Cote GA, Singh VK, Lewis MD, Alkaade S, Sandhu BS, Guda NM, Muniraj T, Tang G, Baillie J, Brand RE, Gardner TB, Gelrud A, Forsmark CE, Banks PA, Slivka A, Wilcox CM, Whitcomb DC, Yadav D. Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities. The American Journal Of Gastroenterology 2017, 112: 633. PMID: 28244497, PMCID: PMC5828017, DOI: 10.1038/ajg.2017.42.Peer-Reviewed Original ResearchConceptsQuality of lifeMild-moderate painCurrent smokingChronic pancreatitisMCS scoresConstant painCP patientsSevere painShort Form-12 (SF-12) surveyMental component summary scoresConstant severe painComponent summary scoresMultivariable linear regression modelsAssociated co morbiditiesIndependent effectsFinal multivariable modelNAPS2 studySignificant independent effectDisease durationCo morbiditiesMean PCSIndependent predictorsMultivariable analysisPancreatic surgeryPCS scores
2016
961 Quality of Life (QOL) in Chronic Pancreatitis (CP) Is Determined by Constant Pain, Disability, Current Smoking and Associated Co-Morbidities
Machicado J, Amann S, Anderson M, Abberbock J, Sherman S, Conwell D, Cote G, Singh V, Wilcox C, Lewis M, Alkaade S, Sandhu B, Guda N, Muniraj T, Tang G, Baillie J, Brand R, Gardner T, Gelrud A, Forsmark C, Banks P, Slivka A, Whitcomb D, Yadav D. 961 Quality of Life (QOL) in Chronic Pancreatitis (CP) Is Determined by Constant Pain, Disability, Current Smoking and Associated Co-Morbidities. Gastroenterology 2016, 150: s191-s192. DOI: 10.1016/s0016-5085(16)30723-5.Peer-Reviewed Original Research