2014
Hypothalamic Sidedness in Mitochondrial Metabolism
Toth I, Kiss DS, Goszleth G, Bartha T, Frenyo LV, Naftolin F, Horvath TL, Zsarnovszky A. Hypothalamic Sidedness in Mitochondrial Metabolism. Reproductive Sciences 2014, 21: 1492-1498. PMID: 24740989, DOI: 10.1177/1933719114530188.Peer-Reviewed Original Research
2003
Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction
Shansky RM, Glavis-Bloom C, Lerman D, McRae P, Benson C, Miller K, Cosand L, Horvath TL, Arnsten AF. Estrogen mediates sex differences in stress-induced prefrontal cortex dysfunction. Molecular Psychiatry 2003, 9: 531-538. PMID: 14569273, DOI: 10.1038/sj.mp.4001435.Peer-Reviewed Original ResearchConceptsMajor depressive disorderFemale ratsBenzodiazepine inverse agonistPrefrontal cortex dysfunctionStress-related disordersSex differencesEstrogen replacementPrefrontal cortex functionDepressive disorderOvariectomized femalesPFC dysfunctionLow dosesCortex functionInverse agonistUncontrollable stressAnxiety disordersDisordersNeurobiological basisDysfunctionRatsPresent studyStress systemExposureMemory taskProestrus
1998
Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat
Horvath T, Cela V, van der Beek E. Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat. Brain Research 1998, 795: 277-281. PMID: 9622650, DOI: 10.1016/s0006-8993(98)00208-x.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideGnRH neuronsInvolvement of VIPGonadotrophin-releasing hormoneDouble-labeling immunocytochemistryGender-specific regulationVIP axonsVIP boutonsVIP fibersGonadotrophin releaseIntestinal peptideFemale ratsDimorphic interactionNeuronsRatsAxonsHypothalamusBoutonsHormone
1996
Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge.
Naftolin F, Mor G, Horvath TL, Luquin S, Fajer AB, Kohen F, Garcia-Segura LM. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology 1996, 137: 5576-80. PMID: 8940386, DOI: 10.1210/endo.137.12.8940386.Peer-Reviewed Original ResearchConceptsSynaptic retractionArcuate nucleusAxosomatic synapsesPreovulatory gonadotropinEstrous cycleMorning of metestrusPhysiological synaptic plasticitySurge of gonadotropinsMorning of estrusPreovulatory LH surgePreovulatory estradiolPreovulatory levelsLH surgeGonadotropin surgeHypothalamic mechanismsSynaptic remodelingEstrogen diethylstilbestrolSynaptic plasticityGonadotropinOvarian cycleControl femalesSynapsesPositive controlEstradiolEstrogenMorphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus
Horvath TL, Naftolin F, Leranth C, Sahu A, Kalra SP. Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology 1996, 137: 3069-3077. PMID: 8770933, DOI: 10.1210/endo.137.7.8770933.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsArcuate Nucleus of HypothalamusAxonsCerebral VentriclesColchicineDendritesEstradiolEstrusFemaleGalaninHypothalamusHypothalamus, AnteriorImmunoenzyme TechniquesImmunohistochemistryLuteinizing HormoneMicroscopy, ImmunoelectronNeuronsNeuropeptide YOvariectomyParaventricular Hypothalamic NucleusPreoptic AreaProgesteroneRatsRats, Sprague-DawleySignal TransductionSubstance PSupraoptic NucleusConceptsNeuropeptide YMedial preoptic areaLH releaseGAL neuronsArcuate nucleusIntraventricular injectionParaventricular nucleusPreoptic areaSupraoptic nucleusSynaptic connectionsBasal LH releaseNPY-immunoreactive axonsPituitary hormone secretionPituitary gonadotropin releaseRelease of gonadotropinsMicroscopic examinationHypothalamic peptidergic systemsPeroxidase-antiperoxidase techniqueAvidin-biotin peroxidaseLight microscopic examinationMechanism of actionDiaminobenzidine reactionGAL releaseNPY inputNPY administration