2017
Mitochondria Bioenergetic and Cognitive Functions: The Cannabinoid Link
Mancini G, Horvath TL. Mitochondria Bioenergetic and Cognitive Functions: The Cannabinoid Link. Trends In Cell Biology 2017, 27: 391-392. PMID: 28487182, DOI: 10.1016/j.tcb.2017.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCannabinoidsCognitionEnergy MetabolismHumansMitochondriaModels, BiologicalSignal Transduction(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity
Harkany T, Horvath TL. (S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity. Cell Metabolism 2017, 25: 8-10. PMID: 28076767, DOI: 10.1016/j.cmet.2016.12.020.Peer-Reviewed Original ResearchMeSH KeywordsCannabinoidsHumansMemoryMitochondriaReceptor, Cannabinoid, CB1Receptors, CannabinoidSignal Transduction
2015
Hypothalamic POMC neurons promote cannabinoid-induced feeding
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.Peer-Reviewed Original ResearchConceptsPOMC neuronsΒ-endorphinHypothalamic pro-opiomelanocortin (POMC) neuronsOpioid peptide β-endorphinHypothalamic POMC neuronsPromotion of feedingPro-opiomelanocortin (POMC) neuronsCannabinoid receptor 1CB1R activityPOMC activitySated miceHormone releaseHypothalamic administrationFood intakeCentral regulationNeuronal activityParadoxical increaseCB1RReceptor 1POMC cellsNeuronsMitochondrial adaptationsDecreased activityPOMC geneUnsuspected role
2005
Cannabinoids, opioids and eating behavior: The molecular face of hedonism?
Cota D, Tschöp MH, Horvath TL, Levine AS. Cannabinoids, opioids and eating behavior: The molecular face of hedonism? Brain Research Reviews 2005, 51: 85-107. PMID: 16364446, DOI: 10.1016/j.brainresrev.2005.10.004.Peer-Reviewed Original ResearchConceptsOpioid receptor antagonistPrevalence of obesityAnti-obesity drugsAnti-obesity therapiesCentral nervous mechanismsAddictive componentOpioid systemReceptor antagonistEnergy balance controlFood intakeNervous mechanismsAddictive propertiesEnergy homeostasisHealth threatLife expectancyBody of dataRewarding valueAlarming increaseObesityBalance controlHomeostatic componentWestern countriesFunctional interactionHedonic aspectsOpioids
2003
Endocannabinoids and the regulation of body fat: the smoke is clearing
Horvath TL. Endocannabinoids and the regulation of body fat: the smoke is clearing. Journal Of Clinical Investigation 2003, 112: 323-326. PMID: 12897199, PMCID: PMC166302, DOI: 10.1172/jci19376.Peer-Reviewed Original Research