2017
Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus
Morozov YM, Koch M, Rakic P, Horvath TL. Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus. Molecular Metabolism 2017, 6: 374-381. PMID: 28377876, PMCID: PMC5369208, DOI: 10.1016/j.molmet.2017.01.004.Peer-Reviewed Original Research
2014
Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding
Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC. Neonatal Insulin Action Impairs Hypothalamic Neurocircuit Formation in Response to Maternal High-Fat Feeding. Cell 2014, 156: 495-509. PMID: 24462248, PMCID: PMC4101521, DOI: 10.1016/j.cell.2014.01.008.Peer-Reviewed Original ResearchConceptsPOMC neuronsMaternal high-fat diet (HFD) feedingOrexigenic agouti-related peptide (AgRP) neuronsHealth outcomesMaternal high-fat feedingHigh-fat diet feedingImpaired glucose-stimulated insulin secretionMaternal HFD feedingGlucose-stimulated insulin secretionImpaired glucose homeostasisOffspring health outcomesHigh-fat feedingPOMC projectionsParasympathetic innervationHFD feedingMaternal overnutritionPeptide neuronsAbnormal insulinAnorexigenic proopiomelanocortinParaventricular nucleusDiet feedingInsulin secretionMelanocortin circuitryNeuropeptide expressionLong-term effects
2012
Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation. Cell Metabolism 2012, 15: 247-255. PMID: 22285542, PMCID: PMC3278575, DOI: 10.1016/j.cmet.2011.12.016.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAnimalsArcuate Nucleus of HypothalamusAutophagyAutophagy-Related Protein 7AxonsBody WeightGlucose IntoleranceImmunoblottingMetabolic Networks and PathwaysMiceMicroscopy, ElectronMicrotubule-Associated ProteinsNeuronsPro-OpiomelanocortinTranscription Factor TFIIHTranscription FactorsUbiquitinConceptsPOMC neuronsHypothalamic melanocortin systemPathogenesis of obesityImportant intracellular mechanismNormal metabolic regulationP62-positive aggregatesFunctional neural systemsGlucose intoleranceAge-dependent accumulationNeonatal lifeAxonal projectionsMetabolic dysregulationMetabolic impairmentMelanocortin systemEssential autophagy geneBody weightLoss of autophagyMajor negative regulatorAxon growthIntracellular mechanismsNeuronsAutophagy deficiencyNeural developmentDirect genetic evidenceAtg7
2011
CPG15 regulates synapse stability in the developing and adult brain
Fujino T, Leslie JH, Eavri R, Chen JL, Lin WC, Flanders GH, Borok E, Horvath TL, Nedivi E. CPG15 regulates synapse stability in the developing and adult brain. Genes & Development 2011, 25: 2674-2685. PMID: 22190461, PMCID: PMC3248687, DOI: 10.1101/gad.176172.111.Peer-Reviewed Original ResearchConceptsSynaptic maturationDendritic spinesFunctional synaptic contactsNeural circuit developmentSynaptic contactsSpine maintenanceDiolistic labelingDendritic arborsMature brainCircuit refinementSynapse stabilityAdult brainKnockout miceSynapse stabilizationCPG15Active synapsesSpine numberActivity-dependent synapseDevelopmental maturationSpineNeuronal branchesCircuit developmentGradual attritionBrainSynapses
2006
Retinopetal Axons in Mammals: Emphasis on Histamine and Serotonin
Gastinger MJ, Tian N, Horvath T, Marshak DW. Retinopetal Axons in Mammals: Emphasis on Histamine and Serotonin. Current Eye Research 2006, 31: 655-667. PMID: 16877274, PMCID: PMC3351198, DOI: 10.1080/02713680600776119.Peer-Reviewed Original ResearchConceptsRetinopetal axonsEffects of serotoninCentral nervous systemRetina of mammalsDorsal rapheHistaminergic neuronsOptic nervePosterior hypothalamusInner retinaBrain stemRetinal neuronsNervous systemRetinal diseasesAxonsArousal systemNeuronsHistamineAnatomical studyRetinaPerikaryaSerotoninNerveHypothalamusEtiologyRaphe
2003
Fasting Activates the Nonhuman Primate Hypocretin (Orexin) System and Its Postsynaptic Targets
Diano S, Horvath B, Urbanski HF, Sotonyi P, Horvath TL. Fasting Activates the Nonhuman Primate Hypocretin (Orexin) System and Its Postsynaptic Targets. Endocrinology 2003, 144: 3774-3778. PMID: 12933647, DOI: 10.1210/en.2003-0274.Peer-Reviewed Original ResearchConceptsPerifornical regionArcuate nucleusHypothalamic regulationC-Fos-expressing cellsLateral hypothalamic cellsC-fosMedial preoptic areaVariety of endocrineC-fos expressionDiverse brain regionsHCRT axonsLeptin levelsNuclear c-FosDorsomedial hypothalamusAsymmetric synapsesBasal forebrainPresent studyPostsynaptic targetsDorsomedial nucleusNeuropeptide Y.Preoptic areaThalamic nucleiHcrt neuronsHcrt systemAxon terminals
2000
Hormonal regulation of hippocampal spine synapse density involves subcortical mediation
Leranth C, Shanabrough M, Horvath TL. Hormonal regulation of hippocampal spine synapse density involves subcortical mediation. Neuroscience 2000, 101: 349-356. PMID: 11074158, DOI: 10.1016/s0306-4522(00)00369-9.Peer-Reviewed Original ResearchConceptsFimbria/fornix transectionSpine synapse densitySpine densitySynapse densityHippocampal spine synapse densitySubcortical structuresSubcortical mediationPyramidal cell spinesFornix transectionHippocampal CA1 subfieldHippocampal synaptic plasticityCA1 pyramidal cellsFimbria/fornixLong-term potentiationEstrogen replacementIpsilateral hippocampusContralateral hippocampusCA1 subfieldMedian raphePyramidal cellsSupramammillary areaAfferent connectionsHippocampal morphologySeptal complexNew synapses
1998
Tracing of the entorhinal‐hippocampal pathway in vitro
Kluge A, Hailer N, Horvath T, Bechmann I, Nitsch R. Tracing of the entorhinal‐hippocampal pathway in vitro. Hippocampus 1998, 8: 57-68. PMID: 9519887, DOI: 10.1002/(sici)1098-1063(1998)8:1<57::aid-hipo6>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsOuter molecular layerPerforant pathDentate gyrusEntorhinal cortexEntorhinal-hippocampal interactionPerforant path axonsOrganotypic slice culturesMini-RubyPerforant fibersVitro tracingAnterograde degenerationDendritic shaftsLesion paradigmMicroglial cellsNeuronal degenerationEntorhinal neuronsNeurotoxin treatmentMolecular layerSlice culturesAxonal materialGrowth factorSubsequent phagocytosisGyrusEntorhinal-hippocampal regionFurther studiesGender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat
Horvath T, Cela V, van der Beek E. Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat. Brain Research 1998, 795: 277-281. PMID: 9622650, DOI: 10.1016/s0006-8993(98)00208-x.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideGnRH neuronsInvolvement of VIPGonadotrophin-releasing hormoneDouble-labeling immunocytochemistryGender-specific regulationVIP axonsVIP boutonsVIP fibersGonadotrophin releaseIntestinal peptideFemale ratsDimorphic interactionNeuronsRatsAxonsHypothalamusBoutonsHormone
1997
Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex
Horvath T, Roa-Pena L, Jakab R, Simpson E, Naftolin F. Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex. The Journal Of Steroid Biochemistry And Molecular Biology 1997, 61: 349-357. PMID: 9365210, DOI: 10.1016/s0960-0760(97)80032-5.Peer-Reviewed Original ResearchConceptsAxonal processesLimbic areasStria terminalisCritical perinatal periodMedial preoptic areaPostnatal day 5Limbic cortexArcuate nucleusHypothalamic areaNeuronal perikaryaLimbic structuresMedial septumPerinatal periodPreoptic areaDiagonal bandMedial nucleusAxon terminalsImmunoreactive elementsPerikaryal labelingPeriventricular regionLateral septumBed nucleusParacrine actionRat brainLateral habenula
1996
Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus
Horvath TL, Naftolin F, Leranth C, Sahu A, Kalra SP. Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology 1996, 137: 3069-3077. PMID: 8770933, DOI: 10.1210/endo.137.7.8770933.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsArcuate Nucleus of HypothalamusAxonsCerebral VentriclesColchicineDendritesEstradiolEstrusFemaleGalaninHypothalamusHypothalamus, AnteriorImmunoenzyme TechniquesImmunohistochemistryLuteinizing HormoneMicroscopy, ImmunoelectronNeuronsNeuropeptide YOvariectomyParaventricular Hypothalamic NucleusPreoptic AreaProgesteroneRatsRats, Sprague-DawleySignal TransductionSubstance PSupraoptic NucleusConceptsNeuropeptide YMedial preoptic areaLH releaseGAL neuronsArcuate nucleusIntraventricular injectionParaventricular nucleusPreoptic areaSupraoptic nucleusSynaptic connectionsBasal LH releaseNPY-immunoreactive axonsPituitary hormone secretionPituitary gonadotropin releaseRelease of gonadotropinsMicroscopic examinationHypothalamic peptidergic systemsPeroxidase-antiperoxidase techniqueAvidin-biotin peroxidaseLight microscopic examinationMechanism of actionDiaminobenzidine reactionGAL releaseNPY inputNPY administrationAromatase Immunoreactivity in Axon Terminals of the Vertebrate Brain
Naftolin F, Horvath T, Jakab R, Leranth C, Harada N, Balthazart J. Aromatase Immunoreactivity in Axon Terminals of the Vertebrate Brain. Neuroendocrinology 1996, 63: 149-155. PMID: 9053779, DOI: 10.1159/000126951.Peer-Reviewed Original ResearchConceptsAxon terminalsAromatase immunoreactivityAxonal processesDifferent vertebrate speciesAdult central nervous systemRole of aromataseSmall clear synaptic vesiclesCentral nervous systemClear synaptic vesiclesVertebrate speciesSubcellular locationMost vertebratesSpecific limbicNeuronal perikaryaAromatase activityElectron microscopic examinationEstrogen synthesisHypothalamic structuresSubcellular distributionSynaptic levelVertebrate brainNervous systemBrain aromataseMolecular biologyIntraneuronal production
1993
Aromatase immunoreactivity in the rat brain: Gonadectomy-sensitive hypothalamic neurons and an unresponsive “limbic ring” of the lateral septum-bed nucleus-amygdala complex
Jakab RL, Horvath TL, Leranth C, Harada N, Naftolin F. Aromatase immunoreactivity in the rat brain: Gonadectomy-sensitive hypothalamic neurons and an unresponsive “limbic ring” of the lateral septum-bed nucleus-amygdala complex. The Journal Of Steroid Biochemistry And Molecular Biology 1993, 44: 481-498. PMID: 8476763, DOI: 10.1016/0960-0760(93)90253-s.Peer-Reviewed Original ResearchConceptsAromatase-immunoreactive neuronsRat brainAromatase systemStria terminalisLateral septal areaDorsomedial hypothalamic nucleusCentral amygdaloid nucleusMidline thalamic regionAxon-like processesDorsolateral hypothalamic areaNeuron systemConversion of androgensLaterodorsal divisionSubincertal nucleusHuman placental aromataseAromatase immunoreactivityBrain distributionGonadectomized ratsHypothalamic areaHypothalamic neuronsAmygdaloid nucleusLimbic areasHypothalamic nucleiZona incertaSeptal areaLuteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular Areas
Horvath T, Naftolin F, Leranth C. Luteinizing Hormone‐Releasing Hormone and Gamma‐Aminobutyric Acid Neurons in the Medial Preoptic Area are Synaptic Targets of Dopamine Axons Originating in Anterior Periventricular Areas. Journal Of Neuroendocrinology 1993, 5: 71-79. PMID: 8097941, DOI: 10.1111/j.1365-2826.1993.tb00365.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsCerebral VentriclesColchicineDopamineFemaleGamma-Aminobutyric AcidGlutamate DecarboxylaseGonadotropin-Releasing HormoneImmunohistochemistryMicroscopy, ElectronNeuronsOxidopaminePhytohemagglutininsPreoptic AreaRatsRats, Sprague-DawleySynapsesTissue FixationTyrosine 3-MonooxygenaseConceptsHormone-releasing hormoneMedial preoptic areaGlutamic acid decarboxylasePhaseolus vulgaris leucoagglutininZona incertaPreoptic areaTyrosine hydroxylaseGlutamic acid decarboxylase-immunoreactive neuronsDopamine axonsTyrosine hydroxylase-immunoreactive boutonsAcid decarboxylaseGamma-aminobutyric acid (GABA) neuronsRat medial preoptic areaAnterior periventricular areaDesipramine-pretreated ratsDopamine axon terminalsAnteroventral periventricular nucleusCell of originEarly morphological signsDopaminergic connectionsGABA neuronsGABA cellsPeriventricular areaAcute degenerationSynaptic contacts