2022
AgRP neurons control structure and function of the medial prefrontal cortex
Stutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry 2022, 27: 3951-3960. PMID: 35906488, PMCID: PMC9891653, DOI: 10.1038/s41380-022-01691-8.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexAgRP neuronsNon-selective dopamine receptor antagonistBrain functionPrefrontal cortexHypothalamic AgRP neuronsMedial thalamic neuronsAdministration of clozapineDopamine receptor antagonistVentral tegmental areaOscillatory network activityHigher-order brain functionsHypothalamic agoutiThalamic neuronsChemogenetic inhibitionDopaminergic neuronsReceptor antagonistTegmental areaNeuronal pathwaysSensorimotor gatingAdult miceModulatory impactAmbulatory behaviorConstitutive impairmentNeuronsA hypothalamic pathway for Augmentor α–controlled body weight regulation
Ahmed M, Kaur N, Cheng Q, Shanabrough M, Tretiakov EO, Harkany T, Horvath TL, Schlessinger J. A hypothalamic pathway for Augmentor α–controlled body weight regulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2200476119. PMID: 35412887, PMCID: PMC9169862, DOI: 10.1073/pnas.2200476119.Peer-Reviewed Original ResearchConceptsParaventricular nucleusBody weightDiet-induced obesityBody weight regulationDiscrete neuronal populationsMelanocortin receptor 4Whole-body energy homeostasisPhysiological rolePeptide neuronsHypothalamic pathwaysReceptor 4Neuronal pathwaysPhysical activityLittermate controlsWeight regulationNeuronal populationsMetabolic diseasesTherapeutic opportunitiesMutant miceEnergy homeostasisMiceALKCancerHuman cancersALK mutants
2017
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1
Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, Szigeti-Buck K, Yi CX, Schriever SC, Tattikota SG, Carlo AS, Moroni M, Siemens J, Heuser A, van der Weyden L, Birkenfeld AL, Niendorf T, Poulet JFA, Horvath TL, Tschöp MH, Heinig M, Trajkovski M, Haucke V, Poy MN. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nature Neuroscience 2017, 20: 1096-1103. PMID: 28628102, PMCID: PMC5533218, DOI: 10.1038/nn.4590.Peer-Reviewed Original Research
1997
Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies
Van Der Beek E, Horvath T, Wiegant V, Van Den Hurk R, Buijs R. Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin‐releasing hormone system: Combined tracing and light and electron microscopic immunocytochemical studies. The Journal Of Comparative Neurology 1997, 384: 569-579. PMID: 9259490, DOI: 10.1002/(sici)1096-9861(19970811)384:4<569::aid-cne6>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsSuprachiasmatic nucleusFemale ratsGnRH systemGnRH-immunoreactive cell bodiesGonadotropin-releasing hormone (GnRH) neuronsDaily LH surgesImplantation of estrogenOvariectomized rats resultsRostral ventrolateral portionGonadotropin-releasing hormone (GnRH) systemVasoactive intestinal polypeptideElectron microscopic immunocytochemical studyHormone neuronsGnRH neuronsIntestinal polypeptideLH surgeMonosynaptic pathwayPutative transmittersAnterograde tracerPreoptic areaNeuronal pathwaysRats resultsVentrolateral portionBilateral projectionsFemale rodents