2012
Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center
Horvath TL, Abizaid A, Dietrich MO, Li Y, Takahashi JS, Bass J. Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center. Molecular Metabolism 2012, 1: 79-85. PMID: 24024121, PMCID: PMC3757645, DOI: 10.1016/j.molmet.2012.08.003.Peer-Reviewed Original ResearchHypothalamic neuronsOrexin/hypocretin neuronsOrexin/hypocretin systemUnique anatomical distributionDirect synaptic inputGrowth hormone releaseLateral geniculate nucleusHypothalamic arousal systemsHypocretin neuronsHypothalamic slicesGeniculate nucleusHormone releaseHypocretin systemAnatomical distributionArousal centersSynaptic inputsVisual centersGhrelin mRNAGhrelinArousal systemNeuronsKey mediatorCircadian patternSuprachiasmatic nucleusElectrophysiological activity
2006
Ghrelin controls hippocampal spine synapse density and memory performance
Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschöp MH, Horvath TL. Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience 2006, 9: 381-388. PMID: 16491079, DOI: 10.1038/nn1656.Peer-Reviewed Original ResearchConceptsHippocampal spine synapse densitySpine synapse densitySpine synapse formationGrowth hormone releaseNovel therapeutic strategiesLong-term potentiationHigher brain functionsEnhanced spatial learningGut hormonesGhrelin administrationHypothalamic actionSynapse densitySpine synapsesCA1 regionHormone releaseNeuropeptide ghrelinGhrelin bindingHippocampal formationTherapeutic strategiesMelanocortin systemGhrelinBrain areasMetabolic controlSynaptic changesSynaptic plasticity