2016
Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine
Jocsak G, Kiss DS, Toth I, Goszleth G, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine. International Journal Of Environmental Research And Public Health 2016, 13: 619. PMID: 27338438, PMCID: PMC4924076, DOI: 10.3390/ijerph13060619.Peer-Reviewed Original ResearchConceptsERβ mRNA expressionModulatory roleMRNA expressionCerebellar cell culturesGlial cellsEstrogen receptor β mRNA expressionEndocrine disruptorsAbsence of E2ED effectsPrimary cerebellar cell culturesΒ mRNA expressionAdverse health effectsHormonal milieuBody of evidenceHormone deficiencyCell culturesTriiodo-ThyronineHealth effectsEnvironmental substancesSimultaneous exposureEstradiolComparison of individualsObserved potencyE2T3
2010
Estrogen Promotes Parvalbumin Expression in Arcuate Nucleus POMC Neurons
Sotonyi P, Gao Q, Bechmann I, Horvath TL. Estrogen Promotes Parvalbumin Expression in Arcuate Nucleus POMC Neurons. Reproductive Sciences 2010, 17: 1077-1080. PMID: 20713969, DOI: 10.1177/1933719110379651.Peer-Reviewed Original ResearchConceptsPOMC neuronsArcuate nucleus neuronsLean body massSuppression of feedingSuppress appetiteParvalbumin expressionEstrogen treatmentHypothalamic neuronsArcuate nucleusNeuronal degenerationNucleus neuronsFemale miceCalcium overloadExcitatory activityCalcium-binding proteinsCalcium influxReceptor presenceCalcium entrySustained satietyNeuronsEnergy expenditureEstradiolParvalbuminAppetiteBody mass
2005
Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons
Abizaid A, Mezei G, Thanarajasingam G, Horvath TL. Estrogen enhances light‐induced activation of dorsal raphe serotonergic neurons. European Journal Of Neuroscience 2005, 21: 1536-1546. PMID: 15845081, DOI: 10.1111/j.1460-9568.2005.03964.x.Peer-Reviewed Original ResearchConceptsOvariectomized ratsRaphe nucleusDorsal raphe serotonergic neuronsEstradiol-treated ovariectomized ratsAbility of estradiolDouble-labeled cellsFos-immunoreactive cellsRaphe serotonergic neuronsMedian raphe nucleusFos-positive nucleiRaphe nuclei regionMidbrain rapheSerotonin immunocytochemistryOvarian functionSerotonergic neuronsEstrogen treatmentFos immunoreactivitySerotonergic systemFood intakeNeuronal responsesDirect projectionsPhotic stimulationEstradiolEstrogenNormal onset
2003
Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats
Parducz A, Zsarnovszky A, Naftolin F, Horvath TL. Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats. Neuroscience 2003, 117: 791-794. PMID: 12654332, DOI: 10.1016/s0306-4522(02)00967-3.Peer-Reviewed Original ResearchConceptsAxo-somatic contactsArcuate nucleusSynaptic plasticityGABAergic axo-somatic synapsesMorphological synaptic plasticityAxo-somatic synapsesEffects of estradiolSynapse quantificationArcuate neuronsTracer FluorogoldGonadal steroidsAnterior pituitaryAdult ratsHypophysiotropic neuronsMedian eminenceNervous systemTransient decreaseSystemic applicationNeuroendocrine cellsDisector methodNeuronsNumerical densityEstradiolFluorogoldCells
1996
Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge.
Naftolin F, Mor G, Horvath TL, Luquin S, Fajer AB, Kohen F, Garcia-Segura LM. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology 1996, 137: 5576-80. PMID: 8940386, DOI: 10.1210/endo.137.12.8940386.Peer-Reviewed Original ResearchConceptsSynaptic retractionArcuate nucleusAxosomatic synapsesPreovulatory gonadotropinEstrous cycleMorning of metestrusPhysiological synaptic plasticitySurge of gonadotropinsMorning of estrusPreovulatory LH surgePreovulatory estradiolPreovulatory levelsLH surgeGonadotropin surgeHypothalamic mechanismsSynaptic remodelingEstrogen diethylstilbestrolSynaptic plasticityGonadotropinOvarian cycleControl femalesSynapsesPositive controlEstradiolEstrogen