2024
Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Achanta S, Gentile M, Albert C, Schulte K, Pantazides B, Crow B, Quiñones-González J, Perez J, Ford D, Patel R, Blake T, Gunn M, Jordt S. Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l482-l495. PMID: 38318664, PMCID: PMC11281795, DOI: 10.1152/ajplung.00162.2023.Peer-Reviewed Original ResearchAcute lung injuryBronchoalveolar lavage fluidChlorine gasChlorinated fatty acidsDecreased dynamic lung complianceHuman acute lung injuryPeak inspiratory pressureIncreased airway resistanceMedical countermeasuresControlled mechanical ventilationForensic biomarkersDynamic lung complianceFormation of microthrombiProtein adductsAir-exposed groupNeutrophilic alveolitisTesting medical countermeasuresVascular leakageNeutrophil countPulmonary edemaHistopathological featuresPotential medical countermeasuresForensic analysisInspiratory pressureLung injury
2023
The E-cigarette or Vaping Product Use–Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report
Rebuli M, Rose J, Noël A, Croft D, Benowitz N, Cohen A, Goniewicz M, Larsen B, Leigh N, McGraw M, Melzer A, Penn A, Rahman I, Upson D, Alexander L, Ewart G, Jaspers I, Jordt S, Kligerman S, Loughlin C, McConnell R, Neptune E, Nguyen T, Pinkerton K, Witek T. The E-cigarette or Vaping Product Use–Associated Lung Injury Epidemic: Pathogenesis, Management, and Future Directions: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2023, 20: 1-17. PMID: 36584985, PMCID: PMC9819258, DOI: 10.1513/annalsats.202209-796st.Peer-Reviewed Original ResearchConceptsE-cigarettesClinical careOfficial American Thoracic Society Workshop ReportProduct use-associated lung injuryUse-associated lung injuryPublic healthAmerican Thoracic Society workshopSevere pulmonary illnessProspective clinical studyPediatric clinical carePublic health responseElectronic medical recordsBiomarkers of exposureIntegrated electronic medical recordsInjury epidemicLung injuryClinical followCase RegistryPulmonary illnessMedical recordsClinical studiesInhalational toxicityDrug Administration regulationsEVALIExogenous exposure
2019
The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury
Caceres A, Jordt S. The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury. 2019, pa3885. DOI: 10.1183/13993003.congress-2019.pa3885.Peer-Reviewed Original ResearchTRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury
Achanta S, Liu B, Gentile M, Caceres A, Behm D, Burgert M, Costell M, Cheifetz I, Gunn M, Jordt S. TRPV4 Inhibitor Improves Pulmonary Function and Oxygen Saturation in a Pig Translational Model of Chlorine Gas-Induced Acute Lung Injury. 2019, a1017-a1017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a1017.Peer-Reviewed Original Research
2016
Tear gas: an epidemiological and mechanistic reassessment
Rothenberg C, Achanta S, Svendsen ER, Jordt S. Tear gas: an epidemiological and mechanistic reassessment. Annals Of The New York Academy Of Sciences 2016, 1378: 96-107. PMID: 27391380, PMCID: PMC5096012, DOI: 10.1111/nyas.13141.Peer-Reviewed Original ResearchConceptsTear gas agentsPeripheral sensory neuronsRecent epidemiological studiesIon channel TRPV1Lung injuryChronic morbidityOcular injuriesChronic painHigh riskSensory neuronsEpidemiological studiesAnimal modelsGas injuryInjuryPromising effectsMechanistic researchTRPV1Pepper sprayTRPA1Health risksTear gasRiskCivilian populationPotential inhibitorsCough