2024
Nutrient-driven histone code determines exhausted CD8+ T cell fates
Ma S, Dahabieh M, Mann T, Zhao S, McDonald B, Song W, Chung H, Farsakoglu Y, Garcia-Rivera L, Hoffmann F, Xu S, Du V, Chen D, Furgiuele J, LaPorta M, Jacobs E, DeCamp L, Oswald B, Sheldon R, Ellis A, Liu L, He P, Wang Y, Jang C, Jones R, Kaech S. Nutrient-driven histone code determines exhausted CD8+ T cell fates. Science 2024, eadj3020. PMID: 39666821, DOI: 10.1126/science.adj3020.Peer-Reviewed Original ResearchATP-citrate lyaseAcetyl-CoA synthetase 2Histone codeCD8<sup>+</sup> T cell differentiationTumor-specific T-cell responsesACLY inhibitionHistone acetylationCD8+ T cell fateExhausted T cellsT-cell therapyChronic viral infectionsT cell responsesT cell differentiationT cell fateT cell genesTex cellsT cellsEpigenetic modificationsEpigenetic remodelingViral infectionCitrate metabolismNutrient metabolismHistoneAcetylationDifferentiation
2014
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1
Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. Journal Of Clinical Investigation 2014, 124: 3455-3468. PMID: 25003188, PMCID: PMC4109559, DOI: 10.1172/jci66108.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChronic DiseaseCytokinesInflammation MediatorsInterleukin-10Lymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicPositive Regulatory Domain I-Binding Factor 1Receptors, Antigen, T-CellTh1 CellsT-Lymphocyte SubsetsTranscription FactorsConceptsChronic viral infectionsIL-10 expressionT cell responsesIL-10 productionIL-10Th1 cellsViral infectionT cellsBlimp-1Viral-specific T cell responsesChronic lymphocytic choriomeningitis virus (LCMV) infectionAntiviral T cell responsesCell responsesImmunosuppressive cytokine IL-10Virus-specific T cellsLymphocytic choriomeningitis virus infectionChronic LCMV infectionImmunoregulatory IL-10Relevant cellular sourceCytokine IL-10Effector T cellsLCMV-infected micePersistent viral infectionT cell compartmentT cell function